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MUSC researchers develop stem cell therapy that shows promise in one day reversing Type 1 diabetes

A group of researchers at the Medical University of South Carolina (MUSC) has recently developed a new stem cell therapy with a remarkable ability to reverse new-onset Type 1 diabetes (T1D) in a mouse model of the disease.

Hongjun Wang, Ph.D., associate director of the South Carolina Clinical & Translational Research (SCTR) Institute Pilot Program and co-scientific director for the Center for Cellular Therapy, led the team. Co-first authors Hua Wei, Ph.D.; Judong Kim, Ph.D.; and Wenyu Gou, Ph.D., together with other collaborators, conducted most of the work to establish these findings, which were published in the journal Molecular Therapy.

This research study marks a pivotal move away from the current standard of managing blood sugar through multiple daily insulin injections and toward a lasting way to reprogram the immune system itself. For the millions of people currently living with T1D, this could be a game-changer.

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Even though it’s a small percentage, those are real patients. We’re talking about people who are benefiting from this treatment when others have not worked.

Besim Ogretmen, Ph.D. MUSC assistant vice president for research and associate director for basic science at MUSC Hollings Cancer Center

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