ORANGEBURG, S.C. (Mar. 13, 2026) – MUSC Health-Orangeburg has named Matthew M. “Matt” Medley, as its new chief executive officer. Medley officially began his role on March 9, following a thorough search process shaped by input from leaders across the MUSC Health system.
In his new role, Medley will lead the MUSC Health-Orangeburg senior leadership team and report to the Charleston Division CEO. He will also serve on the MUSC Health-Charleston Division executive leadership committee.
“Matt brings a strong track record of operational excellence and strategic leadership,” said Saj Joy, M.D., CEO of MUSC Health-Charleston Division. “He understands how to align clinical operations, financial performance and long-term strategy in a way that drives sustainable growth. His experience across complex health systems will be instrumental as Orangeburg continues to advance its role within MUSC Health and expand services for the region.”
Medley currently serves as the chief operating officer for the MUSC Health-Midlands Division, where he has driven measurable improvements in inpatient admissions, surgical volumes and operational revenue. In partnership with divisional leadership, he has strengthened clinical outcomes while advancing capital planning initiatives to support long-term growth.
Prior to joining MUSC Health in 2023, Medley spent more than seven years at Mayo Clinic, where he held multiple administrative leadership roles, including operations administrator for Mayo Clinic in Jacksonville, Florida, and operations manager for cancer programs. In those roles, he led complex operational improvements across oncology services, elevating efficiency, workforce optimization and patient experience. He led institutional readiness efforts and workforce strategies to support safe, uninterrupted care delivery during the height of the COVID-19 pandemic.
Earlier in his career, Medley served in leadership roles at UF Health and completed administrative training at Johns Hopkins Medicine. He holds a Master of Health Administration and a Bachelor of Health Science from the University of Florida.
Medley is a fellow of the American College of Healthcare Executives, a distinction recognizing his commitment to excellence in health care leadership.
“I am honored to join the Orangeburg team and serve this community,” said Medley. “The dedication the care team and the trust this organization has built with its patients is remarkable. I look forward to supporting our teams, enhancing the overall patient experience and continuing to strengthen the quality and reliability of care our community depends on.”
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About MUSC
Founded in 1824 in Charleston, MUSC is the state’s only comprehensive academic health system, with a mission to preserve and optimize human life in South Carolina through education, research and patient care. Each year, MUSC educates nearly 3,500 students in six colleges and trains approximately 1,050 residents and fellows across its health system. MUSC leads the state in federal, National Institutes of Health and other research funding. For information on our academic programs, visit musc.edu.
As the health care system of the Medical University of South Carolina, MUSC Health is dedicated to delivering the highest-quality and safest patient care while educating and training generations of outstanding health care providers and leaders to serve the people of South Carolina and beyond. In 2025, for the 11th consecutive year, U.S. News & World Report named MUSC Health University Medical Center in Charleston the No. 1 hospital in South Carolina. To learn more about clinical patient services, visit muschealth.org.
MUSC has a total enterprise annual operating budget of $8.9 billion. The nearly 35,000 MUSC members include world-class faculty, physicians, specialty providers, scientists, contract employees, affiliates and care team members who deliver groundbreaking education, research and patient care.
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