To serve patients, health care providers, research scientists, scholars, and society by providing excellence and innovation in diagnostic services and educational resources in a respectful, professional and culturally diverse atmosphere.
To become a preeminent leader in academic anatomic and clinical pathology while translating basic science discovery to improved clinical care.
Demetri Spyropoulos, Ph.D.
Associate Professor, Department of Pathology & Laboratory Medicine
Office: Hollings Cancer Center Room 317
Phone: (843) 792-1625
Fax: (843) 792-5002
B.S., 1981, University of Maryland
Ph.D., 1989, Harvard University
My laboratory employs 'gene targeting' and 'knockout mouse' technologies to study transcription factors that regulate normal development and carcinogenesis. The ultimate goal of this work is to establish animal models for the study and treatment of human disorders involving thoracic structures. Our focus is on the HOX homeobox genes HOXC5 and HOXC6 and their roles in the lungs and esophagus, and on the prototype of the Ets family of genes, Ets1, and its role in the thymus and heart.
Research in this laboratory is supported by grants 1R03 CA109958-01 from the National Cancer Institute and DOD-N6311601M.D.10004 from the Department of Defense.
Maroulakou IG and Spyropoulos DD: The study of HOX gene function in hematopoietic, breast and lung carcinogenesis. Anticancer Res 23: 2101-10, 2003.
Spyropoulos DD, Bartel FO, Higuchi T, Deguchi T, Ogawa M and Watson DK: Marker-assisted study of genetic background and gene-targeted locus modifiers in lymphopoietic phenotypes. Anticancer Res 23: 2015-26, 2003.
Kawada H, Ito T, Pharr PN, Spyropoulos DD, Watson DK and Ogawa M: Defective megakaryopoiesis and abnormal erythroid development in Fli-1 gene-targeted mice. Int J Hematol 73: 463-8, 2001.
Bartel FO, Higuchi T and Spyropoulos DD: Mouse models in the study of the Ets family of transcription factors. Oncogene 19: 6443-54, 2000.
Garcia-Gasca A and Spyropoulos DD: Differential mammary morphogenesis along the anteroposterior axis in Hoxc6 gene targeted mice. Dev Dyn 219: 261-76, 2000.
Spyropoulos DD, Pharr PN, Lavenburg KR, Jackers P, Papas TS, Ogawa M and Watson DK: Hemorrhage, impaired hematopoiesis, and lethality in mouse embryos carrying a targeted disruption of the Fli1 transcription factor. Mol Cell Biol 20: 5643-52, 2000.