The Medical University of South Carolina   Medical Center  ·  College of Medicine ·  Directory   
Department of Pathology Banner MUSC Logo


Our Mission

To serve patients, health care providers, research scientists, scholars, and society by providing excellence and innovation in diagnostic services and educational resources in a respectful, professional and culturally diverse atmosphere.

Our Vision

To become a preeminent leader in academic anatomic and clinical pathology while translating basic science discovery to improved clinical care.



Yong Wang, MD, PhD

Yong Wang, M.D., Ph.D.

Assistant Professor
Department of Pathology & Laboratory Medicine
Office: Walton Research Building Room 401
Address: 39 Sabin Street, Charleston, SC 29425
Phone: (843) 792-9983
Fax: (843) 792-0368

EDUCATION:

M.D., 1990, Chongqing Medical University
Ph.D., 2001, Peking Union Medical College
PostDoctoral Fellow, 2002-2006 Medical University of South Carolina

RESEARCH INTERESTS:

Stem Cell Biology
MicroRNAs and Lung Cancer
Development of Novel Radiosensitizers for Cancer Therapy

FUNDING:

Research programs in the laboratory are supported in part by NIH grants R21 HL106451, P30 CA138313, and U19 AI067770.

OTHER EXPERIENCE AND PROFESSIONAL MEMBERSHIPS:

2003 - present Member, American Society of Hematology
2004 - present Member, Radiation Research Society
2004 – present Member, International Society for Experimental Hematology
2008 - present Member, Hollings Cancer Center
2008 - present Reviewer for Biochem Pharmacol, and J Radiat Res

AWARDS AND HONORS:

1996 Governor’s Award for Science and Technology Excellence, Sichuan Province. Chengdu, China
2000 - Excellent Doctorate Scholarship, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC). Beijing, China
2004-2006 - Scholars-in-Training (SIT) Award, Radiation Research Society
2006 - Travel grant, International Society for Experimental Hematology
2007 - Young Investigator Award, 13th International Congress of Radiation Research, San Francisco, CA
2008 - MUSC Nominee for the Ellison Medical Foundation New Scholar Award

SELECTED PEER-REVIEWED PUBLICATIONS:

  1. Wang Y, Li G, Zheng GG, Song YH, Wu KF. Detection and sequencing analysis of IL-18 expression in J6-1 leukemic cells. Leuk Res 2001; 25: 273-74. PMID: 11261420.
  2. Wang Y, Zheng GG, Wu KF, Li G and Rao Q. Construction of macrophage colony-stimulating factor receptor DNA vaccine. Haematologica 2001; 86: 1219-20. PMID: 11694409.
  3. Wang Y, Li G, Rao Q, Wu KF. Expression of interleukin-18 in human leukemia cell lines and studies on its clinical significance. Zhonghua Yi Xue Za Zhi PMID: 11798931.
  4. Zhang B, Wang Y, Zheng GG, Ma XT, Li G, Wu KF. Clinical significance of IL-18 gene over-expression in AML. Leuk Res 2002; 26: 887-92. PMID: 12163048.
  5. Meng A, Wang Y, Van Zant G, Zhou D. Ionizing radiation and busulfan induce premature senescence in murine bone marrow hematopoietic cells. Cancer Res 2003; 63: 5414-9. PMID: 14500376.
  6. Meng A, Wang Y, Brown SA, Van Zant G, Zhou D. Ionizing Radiation and Busulfan Inhibit Murine Bone Marrow Cell Hematopoietic Function via Apoptosis Dependent and Independent Mechanisms. Exp Hematol, 31:1348-1356, 2003. PMID: 14662344.
  7. Meng A, Yu T, Chen G, Brown SA, Wang Y, Thompson JS, Zhou D. Cellular Origin of IR-Induced NF-kB Activation in vivo and Role of NF-kB in Ionizing Radiation-Induced Lymphocyte Apoptosis. Int J Radiation Biol, 79:849-861, 2003.
  8. Bai A, Meier GP, Wang Y, Luberto C, Hannun YA, Zhou D. Prodrug modification increases D609 chemical stability and cytotoxicity against U937 leukemia cells. J Pharmacol Exp Ther 2004; 309: 1051-9. PMID: 14960662.
  9. Wang Y, Meng A, Zhou D. Inhibition of phosphatidylinostol 3-kinase uncouples H2O2-induced senescent phenotype and cell cycle arrest in normal human diploid fibroblasts. Exp Cell Res 2004; 298:188-96. PMID: 15242773.
  10. Wang Y, Meng A, Lang H, Brown SA, Konopa JL, Kindy MS, Schmiedt RA, Thompson JA, Zhou D. Activation of nuclear factor kappa B in vivo selectively protects the murine small intestine against ionizing radiation-induced damage. Cancer Res 2004; 64: 6240-6. PMID: 15342410.
  11. Probin V, Wang Y, Bai A, and Zhou D. Busulfan selectively induces cellular senescence but not apoptosis in WI38 fibroblasts via a p53-independent but Erk-p38 MAPK-dependent mechanism. J Pharmacol Exp Ther 2006; 319: 551-60. PMID: 16882877. (Abstarct)
  12. Wang Y, Schulte BA, Zhou D. Hematopoietic stem cell senescence and long-term bone marrow injury. Cell Cycle 2006; 5:35-38. PMID: 16319536.
  13. Wang Y, Probin V and Zhou D. Cancer therapy-induced residual bone marrow injury- Mechanisms of induction and implication for therapy. Curr Cancer Ther Rev 2006; 2: 271-9.
  14. Wang Y, Schulte BA, Larue AC, Ogawa M and Zhou D. Total body irradiation selectively induces murine hematopoietic stem cell senescence. Blood 2006; 107:358-66. PMCID: PMC1895367.
  15. Probin V, Wang Y and Zhou D. Busulfan-induced senescence is dependent upon ROS production upstream of the MAPK pathway. Free Radic Biol and Med 2007; 42: 1858-65. PMCID: PMC193987.
  16. Foster K, Wang Y, Zhou D, Wright C. Dependence on PI3K/Akt signaling for malignant rhabdoid tumor cell survival. Cancer Chemother and Pharmacol 2009; 63 (5): 783-91. PMID: 18641990.
  17. Johnso SM, Torrice M, Bell JF, Monahan KB, Jiang Q, Wang Y, Ramsey MR, Jin Jian, Wong KK, Su L, Zhou D and Sharpless NE. Mitigation of hematologic radiation toxicity through pharmacological quiescence in mice. JCI 2010, 120: 2528-36. PMCID: PMC2898594.
  18. Wang Y, Liu L, Pazhanisamy SP, Meng A, Zhou D. Total body irradiation selectively induces persistent oxidative stress in murine hematopoietic stem cells. Free Radic Biol and Med 2010; 48: 348-56. PMCID: PMC2818724.
  19. Pazhanisamy SK, Li H, Wang Y, Batinic-Haberle I, Zhou D. NADPH oxidase inhibition attenuates total body irradiation-induced haematopoietic genomic instability. Mutagenesis 2011; 26: 431-5. PMID: 21415439.
  20. Li D, Wang Y, Wu H, Lu L, Zhang H, Chang J, Zhai Z, Zhang J, Wang Y, Zhou D, Meng A. Mitigation of ionizing radiation-induced bone marrow suppression by p38 inhibition and G-CSF administration. J Radiat Res 2011; 52(6): 712-6. PMID: 21971035
  21. Shao L, Li H, Pazhanisamy SK, Meng A, Wang Y, Zhou D. Reactive oxygen species and hematopoietic stem cell senescence. Int J Hematol 2011; 94 (1): 24-32. PMID: 21567162.
  22. Li H*, Wang Y*, Pazhanisamy SK, Shao L, Meng A, Batinic-Haberle I, Zhou D. Mn(III) meso-tetrakis-(N-ethylpyridinium-2-yl) porphyrin mitigates total body irradiation-induced long-term bone marrow suppression (*Co-first authors). Free Radic Biol Med 2011; 51: 30-37. PMID: 21565268.
  23. Wang Y, Keller J, Liu L, Zhou D. Inhibition of p38 mitogen-activated protein kinase promotes ex vivo hematopoietic stem cell expansion. Stem Cells Dev 2011; 20(7): 1143-52. PMID: 21198398.
  24. Wang Y*, Scheiber MN, Neumann C, Calin GA, Zhou D. MicroRNA Regulation of Ionizing Radiation-Induced Premature Senescence. Int J Radiat Oncol Biol Phys 2011; 81: 839-48. PMCID: PMC3056910. (*Corresponding author)
  25. Wang Y*, Liu L, Zhou D. Inhibition of p38 MAPK Attenuates Ionizing Radiation-Induced Hematopoietic Cell Senescence and Residual Bone Marrow Injury. Rad Res 2011, 176: 743-752. PMID: 22014293 (*Co-corresponding authors).
  26. Diaz-Montero CM, Wang Y, Shao L, Feng W, Zidan AA, Pazoles CJ, Montero AJ, Zhou D. The glutathione disulfide mimetic, NOV-002, inhibits cyclophosphamide-induced hematopoietic and immune suppression by reducing oxidative stress. Free Radic Biol Med 2012; 52 (9): 1560-8. PMCID: PMC3390209.
  27. Zou J, Zou P, Wang J, Li L, Wang Y, Zhou D, Liu L. Inhibition of p38 MAPK activity promotes ex vivo expansion of human cord blood hematopoietic stem cells. Ann Hematol 2012; 91: 813-23. PMID: 22258328.
  28. Burns TA, Subathra M, Signorelli P, Choi Y, Yang X, Wang Y, Villani M, Bhalla K, Zhou D, Luberto C. Sphingomyelin synthase 1 activity is regulated by the BCR-ABL oncogene. J Lipid Res 2013; 54(3):794-805. PMID: 23160178.
  29. An N, Lin YW, Mahajan S, Kellner JN, Wang Y, Li Z, Kraft AS, Kang Y. Pim1 serine/threonine Kinase Regulates the Number and Functions of Murine Hematopoietic Stem Cells. Stem Cells 2013; 31 (6): 1202-12. PMID: 23495171.
  30. Luo H, Yang A, Schulte BA, Wargovich MJ, Wang GY. Resveratrol Induces Premature Senescence in Lung Cancer Cells via ROS-Mediated DNA Damage. PLoS One 2013; 8(3): e60065. PMCID: PMC3606183.
  31. Luo H, Yount C, Lang H, Yang A, Riemer EC, Lyons K, Vanek KN, Silvestri GA, Schulte BA, Wang GY. Activation of p53 with Nutlin-3a radiosensitizes lung cancer cells via enhancing radiation-induced premature senescence. Lung Cancer 2013; 81 (2): 167-73. PMID: 23683497.
  32. Luo H, Wang L, Schulte BA, Yang A, Tang S, Wang GY. Resveratrol enhances ionizing radiation-induced premature senescence in lung cancer cells. Int J Oncol 2013; in press.



Pathology Divisions
Anatomic Pathology
Laboratory Medicine
Research

Department of Pathology and Laboratory Medicine Chairman Dr. Steven L. Carroll
Message from the Chairman


News


Upcoming Events


Copyright 2011 MUSC Department of Pathology and Laboratory Medicine