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To become a preeminent leader in academic anatomic and clinical pathology while translating basic science discovery to improved clinical care.



David Turner, PhD

David Turner, Ph.D.

Assistant Professor, Department of Pathology & Laboratory Medicine
Office: Hollings Cancer Center Room 327
Phone: (843) 792-1522
Fax: (843) 792-3940

EDUCATION:

Bsc (Hons) in Molecular Biology: 1993-1996, University of Newcastle Upon Tyne, England, UK.
Ph.D. in Biochemistry: 1997-2001, University of Newcastle Upon Tyne, England, UK.
Post-Doctoral Fellowship: 2001-2002, University of Newcastle Upon Tyne, England, UK.
Post-Doctoral Fellowship: 2002-2004, Fox Chase Cancer Center, Philadelphia, PA, USA.
Post-Doctoral Fellowship: 2004-2008, Medical University of South Carolina, Charleston, SC, USA

Employment:

Research Assistant Professor: 2008-Present, Medical University of South Carolina, Charleston, SC, USA.

RESEARCH INTERESTS:

Transcriptional regulation of cancer progression and the drug resistance phenotype

SELECTED PUBLICATIONS:

  1. Moussa, O., Feldman, R., Fraig, M., Turner, D.P, and Watson, D.K.: PDEF-dependent modulation of gene expression regulates colon cancer progression. Submitted.
  2. Moussa, O., Findlay, V, Turner, D.P, Fraig, M., Watson, D.K. Mechanisms and functional consequences of PDEF protein expression loss during prostate cancer progression.Submitted.
  3. Schaefer, J.S., Jiang, J., Shi, H.Y., Sriraman, V., Turner, D.P., Watson, D.K., Richards, J., and Ming Zhang. (2008). PDEF expression inhibits breast cancer growth in vitro and in vivo. Submitted.
  4. V.J. Findlay, D.P. Turner, O. Moussa, and D.K. Watson. (2008) miRNA-mediated regulation of PDEF in breast cancer. Accepted with revision Cancer Res.
  5. Turner, D.P, Findlay, V.J., Moussa, O, and Watson, D.K. (2008). Global gene expression analysis identifies PDEF regulatory circuits during metastatic progression. Mol, Biol. Cell in press.
  6. Turner, D.P and Watson, D.K. (2008). ETS transcription factors – Oncogenes and tumor suppressor genes that drive prostate cancer. Expert Rev. Anticancer Ther.8(1), 33–42.
  7. Turner, D.P., Findlay, V.J., Moussa, O., and Watson, D.K. (2007). Defining ETS Transcription Regulatory Networks and their Contribution to Breast Cancer Progression. J. Cell. Biochem 102(3): 549–559.
  8. Turner, D.P., Moussa, O., Sauane, M., Fisher, P.B., and Watson, D.K. (2007) Prostate-Derived ETS Factor Is a Mediator of Metastatic Potential through the Inhibition of Migration and Invasion in Breast Cancer. Cancer Res 67: (4), 1618-1625.
  9. Turner, D.P., Cortellino, S., Schupp, J.E., Caretti, E., Loh, T., Kinsella, T.J. and Bellacosa, A. (2006) The DNA N-glycosylase MED1 exhibits preference for halogenated. pyrimidines and is involved in the cytotoxicity of 5-iododeoxyuridine. Cancer Res 66: (15), 7686-7693.
  10. Cortellino, S., Turner, D.P., Albino, D., and Bellacosa, A. (2003). The base excision enzyme MED1 mediates DNA damage response to anti-tumor drugs by maintaining the integrity of the mismatch repair system. PNAS, 100 (25) 15071-6 (Front cover feature and commentary published in same issue).
  11. Turner, D.P. and Bellacosa, A. (2003). Insights into DNA recombination from the structure of a RAD51-BRCA2 complex – A critical commentary. Women’s Oncol. Rev. 3: 43-45.
  12. Cortellino, S., Turner, D.P., Albino, D. and Bellacosa, A. (2004). Induction of deoxyribonucleic Acid damage by alkylating agents. Methods Mol Biol. 285:121-6.
  13. Cortellino, S., Turner, D.P. and Bellacosa, A. (2004). Induction of Deoxyribonucleic Acid Damage by gamma Irradiation. Methods Mol. Biol. 285: 127-32.
  14. Turner, D.P., Yeung, A.T. and Bellacosa, A. (2004). Ultraviolet irradiation of cells. Methods Mol. Biol. 285: 133-138.
  15. Gonzalez-Nicieza, R., Turner, D.P. and Connolly, B.A. (2001). DNA Binding and Cleavage Selectivity of the E.coli DNA G:T mismatch endonuclease (vsr protein). J. Mol. Biol. 310 (3), 501-508.
  16. Turner, D.P. and Connolly, B.A. (2000). Interaction of the E.coli DNA G:T-mismatch Endonuclease (vsr protein) with Oligonucleotides Containing its Target Sequence. J Mol. Biol. 304 (5): 765-778.
  17. Curtin, N.J. and Turner, D.P. (1999). Dipyridamole-mediated Reversal of Multidrug Resistance in MRP Over-expressing Human Lung Carcinoma Cells In Vitro. Euro. J. Cancer. 35 (6): 1020-1026.


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