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Chandrakala Puligilla, PhD

Chandrakala Puligilla, PhD

Assistant Professor
Department of Pathology & Laboratory Medicine
Office: Walton Research Bldg., Rm. 403B
Lab: Walton Research Bldg., Rm. 403
Phone: (843) 792-9398
Fax:(843) 792-0368

EDUCATION:

University of Sussex, England, M.Sc, 2000
University of Sussex, England, Ph.D., 2004

RESEARCH INTERESTS:

During embryonic development, multi-potent progenitors use cell-extrinsic and intrinsic signals to determine cellular fate and patterning and elucidating the mechanisms by which they do so remains to be a challenge in developmental biology. The developing mammalian inner ear is comprised of multi-potent progenitor population of cells that gives rise to a diverse array of cell types, including mechanosensory hair cells, nonsensory supporting cells, and neurons.

The overall goal of our study is to identify genetic regulatory networks involved in cell fate specification and comprehend how different cell types are assembled with stereotyped precision. This requires identification and detailed understanding of signaling pathways that impart positional identity to different cell types within the developing cochlea and to define the mechanisms that link precise coordination between fate specificity, positional identity, and cellular patterning. Dr. Puligilla's goal is to understand fundamental developmental events and to use this knowledge towards the development of methodologies that could be used to target or reinitiate the replacement of different cell types including spiral ganglion neurons in an ageing ear and hearing impaired individuals.

SELECTED PUBLICATIONS:

  1. Jacques, B., Puligilla, C., Weichert, RM., Ferrer-Vaquer, A., Hadjantonakis, AK., Kelley, MW., Dabdoub, A (2012). A dual function for canonical Wnt/b-catenin signaling in the developing mammalian cochlea. Development. 139:4395-4404.
  2. Hertzano, R., Puligilla, C., Chan, SL., Timothy, C., Depireux, DA., Ahmed, Z., Wolf, J., Eisenman, DJ., Friedman, TB., Riazuddin, S., Kelley, MW., Strome SE (2010). CD44 is a marker for the outer pillar cells in the early postnatal mouse inner ear. Journal of the Association for Research in Otolaryngology. 11:407-418.
  3. Puligilla, C., Dabdoub, A., Brenowitz, SB., Kelley, MW (2010). Sox2 induces ectopic neuron formation in the developing mammalian cochlea. Journal of Neuroscience. 30:714-722
  4. Puligilla, C., Kelley, MW (2009). Building the world's best hearing aid; regulation of cell fate in the cochlea. Current Opinion in Genetics & Development. 19:368-373.
  5. Kelley, MW., Driver, EC., Puligilla, C (2009) Regulation of cell fate and patterning in the developing mammalian cochlea. Current Opinion in Otolaryngology Head & Neck Surgery, 17:381-387.
  6. Puligilla, C., Kelley, MW (2009). Cell type specification: Neuronal cell subtype specification: Ear: Hair cell differentiation. New Encyclopedia of Neuroscience edited by George Adelman and Barry H. Smith. pp: 999-1004.
  7. Dabdoub, A., Puligilla, C., Cheah, KSE., Jones, J., Pevny, LH., Fritzsch, B., Kelley, MW (2008). Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea. Proceedings of the National Academy of Sciences, U.S.A. 105:18396-18401
  8. Puligilla, C., Feng, F., Ishikawa, K., Bertuzzi, S., Dabdoub, A., Griffith, AJ., Fritzsch, B., Kelley, MW (2007). Disruption of Fibroblast Growth Factor Receptor 3 signaling results in defects in cellular differentiation, neuronal patterning, and hearing impairment. Developmental Dynamics. 236:1905-1917


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