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To become a preeminent leader in academic anatomic and clinical pathology while translating basic science discovery to improved clinical care.

Mako Ogawa, MD, Ph.D.

Mako Ogawa, M.D., Ph.D.

Hans and Helen Koebig Professor, Department of Pathology & Laboratory Medicine
Office: Ralph H. Johnson VA Medical Center Research Services Room 151
Phone: (843) 789-6712
Fax: (843) 876-5381


1958-1964 M.D., Osaka University Medical School, Osaka, Japan
1970-1973 Ph.D., University of Toronto, Institute of Medical Science, Toronto, Canada


1964-1965 - Rotating Intern, US Naval Hospital, Jokosuka, Japan
1965-1966 - Resident in Medicine, The Third Department of Internal Medicine, Osaka University Hospital, Osaka, Japan
1966-1968 - Resident in Medicine, Dartmouth Medical School Affiliated Hospitals, Hanover, NH
1968-1970 - Fellow in Hematology, Department of Medicine, Dartmouth Medical School, Hanover, NH


My research interest has been in the cellular physiology of hematopoietic stem cells (HSCs). Current focus is in the tissue reconstituting potentials of HSCs.


  1. LaRue AC, Masuya M, Ebihara Y, Fleming PA, Visconti RP, Ogawa M, and Drake, CJ: Hematopoietic origins of fibroblasts: I. In vivo studies of fibroblasts associated with solid tumors. Exp Hematol 34:208-218, 2006.
  2. Ebihara Y, Masuya M, LaRue AC, Yang S, Owens RW, Argraves K, Visconti RP, Fleming PA, Minamiguchi H, Hill WD, Martin-Studdard A, Drake CJ, Ogawa M: Hematopoietic origin of fibroblasts: II. In vitro studies of fibroblasts, CFU-F and fibrocytes. Exp Hematol 34:219-229, 2006.
  3. Lang H, Ebihara Y, Schmiedt R, Minamiguchi H, Zhou D, Smythe N, Liu L, Ogawa M, Schulte B: Contribution of bone marrow hematopoietic stem cells to adult mouse inner ear: Mesenchymal cells and fibrocytes. J Comp Neurol 496:187-201, 2006.
  4. Visconti RP, Ebihara Y, LaRue AC, Fleming PA, McQuinn TC, Masuya M, Minamiguchi H, Markwald RR, Ogawa M, Drake CJ: An in vivo analysis of hematopoietic stem cell potential: Hematopoietic origin of cardiac valve interstitial cells. Circ Res 98:690-696, 2006
  5. Wang Y, Schulte BA, LaRue AC, Ogawa M, Zhou D. Total body irradiation selectively induces murine hematopoietic stem cell senescence. Blood 107:358-366, 2006.
  6. Ogawa M, LaRue AC, Drake CJ: Hematopoietic Origin of Fibroblasts/Myofibroblasts: Its Patho-physiological Implications. Blood 108:2893-2896, 2006.
  7. LaRue AC, Ogawa M: Hematopoietic origin of fibrocytes. IN: Fibrocyets: New Insights into Tissue Repair and Systemic Sclerosis, Bucala R (ed), World Scientific Publishing Co., Singapore, 2007, pp 61-74.
  8. Ogawa M, LaRue AC: Origin of fibroblast colony-forming units. Exp Hematol 35: 1319-1320, 2007

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Laboratory Medicine

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