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Hainan Lang, M.D., Ph.D.

Hainan Lang, M.D., Ph.D.

Associate Professor
Department of Pathology & Laboratory Medicine
Office: Walton Research Building Rooms 613
Phone: (843) 792-8483
Fax: (843) 792-0368

EDUCATION:

M.D., Jinzhou Medical College, China, 1991
Ph.D., Otolaryngology, Capital University of Medical Science, China, 1997
Residency, Otolaryngology, Jinzhou Medical College
Fellowship, Otolaryngology, Beijing Institute of Otolaryngology, Beijing Tong-Ren Hospital
Postdoc., Purdue University, 1997-1999; Medical University of South Carolina, 1999-2003

PROFESSIONAL EXPERIENCES:

2004 - Research Assistant Professor, Otolaryngology-Head & Neck Surgery, MUSC
2005-2008 - Research Assistant Professor, Pathology and Laboratory Medicine, MUSC
2007 - Member of the Graduate Faculty, the College of Graduate Studies, MUSC
2008 - Assistant Professor, Pathology and Laboratory Medicine, MUSC

RESEARCH INTERESTS:

Stem cell and gene therapy in hearing loss: Our recent studies on adult stem cells and virus-mediated gene therapy are aimed at replacing or regenerating damaged cochlear cells, protecting cochlear cells from apoptosis and promoting functional recovery in animal models of hearing loss. The animal models established in our laboratory include several gene knockout mice, ototoxic drug exposed mice and gerbils, and mouse xenograft models based on severely immune-incompetent mice (humanized mice). Molecular biological, auditory electrophysiological and immunoflourescent techniques, confocal and transmission electron microscopy, stem cell transplantation assays and microsurgery are used in our investigations.

Cellular and molecular mechanisms of auditory nerve survival and degeneration: Genetically modified mouse models have been used for understanding the particular genes in spiral ganglion neuron pathogenesis and potential therapeutic applications. These experiments employ multi-level approaches including gene microarray, real-time RT-PCR, proteomics, protein microarray, western blot analysis, molecular imaging of living cells as well as electrophysiological techniques.

FUNDED PROJECTS:

“Human Hematopoietic Stem Cells and the Aging Inner Ear”
P50 DC00422 Lang (PI) NIH/NIDCD
The major goals are to determine the roles of hematopoietic stem cells on the age-related hearing loss (presbyacusis) in the human inner ear.

“Auditory Nerve Degeneration and Repair”
R01DC012058A1 Lang (PI) NIH/NIDCD
The overall objective of this project is to determine the role of the host microenvironment, with a focus on endogenous glial cells, in regulating the survival and differentiation of transplanted neural stem cells


“Rescuing a Congenital Form of Progressive Hearing Loss in Mice Using Viral Gene Transfer of a MicroRNA”
Research Initiative Award Lang (sub-PI); Fekete (PI) Purdue University/ National Organization for Hearing Research Foundation
This proposal aims to use intracochlear gene delivery to prevent and rescue sensory hair cell degeneration caused by a genetic defect in an established mouse model.

COLLABORATED PROJECTS:

“Inner Ear Ion Transport Mechanisms”
R01 DC00713-16 Schulte (PI) NIH/NIDCD
The major goals are to identify and define the precise cellular and subcellular distribution of diverse ion transport, mediators in the normal inner ear.

“Hematopoietic Origin of Mesenchymal Stem Cells”
R01 DK0077821 Ogawa (PI) NIH/ NIDDK
The major goals are to identify the reconstitution potentials of mouse hematopoietic stem cells, i.e. abilities to generate fat tissues, bones and cartilages.

SELECTED PUBLICATIONS:

  1. Lang H, Bever MM and Fekete DM (2000). Cell Proliferation and Cell Death in the Development Chick Inner Ear. J Comp Neurol. 417:205-220.
  2. R.A. Schmidet and H. Lang (2000). Functional Changes in the Ear with Old Age: a Review. J Acoust Soc Am. 107(5):2797.
  3. Lang H and Fekete DM (2001). Lineage Analysis in the Chicken Inner Ear Show Differences in Clonal Dispersion for Epithelial, Neuronal, and Mesenchymal Cells. Dev Biol. 234:120-137.
  4. Lang H, Schulte BA and Schmiedt RA (2002). Endocochlear Potential and Action Potential Recovery Functions in the C57BL/6J Mouse. Hear Res. 172:118-126.
  5. Schmiedt RA, Okamura H, Lang H and Schulte BA (2002). Ouabain Application to the Round Window of the Gerbil Cochlea: a Model of Auditory Neuropathy and Apoptosis. J Assoc Res Otolaryngol. 03:223-233.
  6. Spiess AC, Lang H, Schulte BA, Spicer SS and Schmiedt RA (2002). Effects of Gap Junction Uncoupling in the Gerbil Cochlea. Laryngoscope. 112: 1635-1641.
  7. Schmiedt RA, Lang H, Okamura H and Schulte BA (2002). Effects of Furosemide Applied Chronically to the Round Window: A Model of Metabolic Presbyacusis. J Neurosci. 22(21):9643-9650.
  8. Lang H, Schulte BA and Schmiedt RA (2003). Cell Division in the Gerbil Inner Ear: Effects of Chronic-Furosemide Treatment and Age. J Assoc Res Otolaryngol. 4(2):164-175.
  9. Wang Y, Meng A, Lang H, Brown S A, Konopa JL, Kindy MS, Schmiedt RA, Thompson JS and Zhou D (2004). Activation of NF-kB in Vivo Selectively Protects the Murine Small Intestine against Ionizing Radiation-Induced Damage. Cancer Res. 64:6240-6246.
  10. Lang H, Schulte BA and Schmied RA (2005). Ouabain Induces Apoptotic Cell Death in Type I Spiral Ganglion Neurons, but not Type II Neurons. J Assoc Res Otolaryngol. 6:63-74.
  11. Lang H, Schulte BA, Zhou D, Smyth N, Spicer SS, and Schmiedt RA (2006) Deficiency of the P50 Subunit of Nuclear-Factor Kappa B Causes Progressive Age-Related Auditory Nerve Degeneration and Increased Susceptibility to Noise-Induced Hearing Loss. J Neurosci. 26(13): 3541-3550.
  12. Lang H, Ebihara Y, Schmiedt RA, Samuel SS, Smythe N, Ogawa M, and Schulte BA (2006) Contribution of Bone Marrow Derived Cells to Adult Mouse Inner Ear: Mesenchymal Cells and Fibrocytes. J Comp Neurol. 496(2): 187-201. F1000 ID12529.
  13. Moody MW, Lang H, Spiess AC, Lambert PR and Schmiedt RA (2006). Topical Application of Mitomycin-C to the Middle Ear is Ototoxic in the Gerbil. Otology & Neurotology. 27(8):1186-1192.
  14. Lang H, Schmiedt RA, Wei L, Michelle H and Schulte BA (2008). Transplantation of Mouse Embryonic Neural Stem Cells into the Inner Ear of an Auditory Neuropathy Model. J. Assoc. Res. Otolaryngol. 9:225-240.
  15. Lang H, Vinu J, Smythe NM, Schulte BA, Dubno JR and Schmiedt RA (2010). Chronic Reduction of Endocochlear Potential Causes the Decline of Auditory Nerve Activity in An Animal Model of Metabolic Presbyacusis. J. Assoc. Res. Otolaryngol. 11: 419-434.
  16. Jyothi V, Li M, Kilpatrick L, Smythe NM, Zhu J, LaRue AC, Zhou D, Schulte BA, Schmiedt RA, Lang H (2010). Unmyelinated Spiral Ganglion Neurons and Neural Loss in Congenic Ly5.1 Mice. J Comp Neurol. 518(16):3254-71.
  17. Lang H, Li M, Kilpatrick LA, Zhu J, Samuvel DJ, Krug EL, Goddard JC (2011). Sox2 Up-Regulation and Glial Cell Proliferation following Degeneration of Spiral Ganglion Neurons in Adult Mouse Inner Ear. J Assoc Res Otolaryngol. 12: 151-171. PMID 21061038. F1000 ID7441956.
  18. Kilpatrick LA, Li Q, Goddard JC, Fekete DM, Lang H (2011). Gene Transfer using AVV Viruses via the Scala Media in the Adult Normal and Deafened Mouse. Gene Ther. 18: 569-78. NIHMS 243660.
  19. Kilpatrick LA, Zhu J, Lee F, Lang H (2011). SDF-1 Expression in the Injured Auditory Nerve. Otolaryngology-Head and Neck Surgery. 145(6):1007-15. PMID 21947792.
  20. Kilpatrick LA, Samuvel DJ, Juhong Zhu J, Smythe N, Lang H (2011). Ouabain-Induced Auditory Nerve Degeneration in Congenic Ly5.1 Mice. Journal of Otology. 6(2):20-30.
  21. Xing Y, Samuvel DJ, Stevens SM, Dubno JR, Schulte BA, Lang H (2012). Age-Related Changes in Myelin Basic Protein in Mouse and Human Auditory Nerve. PLoS ONE. 7(4) e34500: 1-15.
  22. Yan D, Xing Y, Zhu J, Chen Z, Lang H, Liu X (2012). Analysis of MiR-376 Cluster Members in the Mouse Inner Ear. International Journal of Experimental Pathology. In press.

Dr. Langs Research



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