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Weimin Fan, M.D., M.P.H.

Weimin Fan, M.D., M.P.H.

Professor, Department of Pathology & Laboratory Medicine
Professor, Department of Medicine
Department of Pathology & Laboratory Medicine
Office: Walton Research Building Room 709
Phone: (843) 792-5108
Fax: (843) 792-0368

EDUCATION:

M.D., 1983, Zhejiang Medical University
M.P.H., 1986, Zhejiang Medical University

RESEARCH INTERESTS:

Research interests in my laboratory are involved in several areas in cancer therapy and nanotechnology: 1) Hormonal and genetic control of tumor growth and cell cycle regulation. 2) Experimental therapeutics and mechanism of drug-induced apoptosis. 3) Estrogen receptors mediate drug resistance and underlyingmechanisms; 5) The role of cancer stem cells in drug resistance; 4) Explore nanoparticle-based target biochemotherapy for HER2/neu+ Breast Tumors; 5)Screening and preclinical evaluation of antimicrobial nanoparticles.

FUNDING:

Work in the laboratory is supported in part by research grants from the National Cancer Institute and other research foundations.

SELECTED PUBLICATIONS:

  1. Huang Y, Johnson KR, Norris JS and Fan W. Nuclear factor-kB/I-kB signaling pathway may contribute to the mediation of paclitaxel-induced apoptosis in solid tumor cells. Cancer Res. 60:4426-4432, 2000. PMID: 10969788
  2. Zeng S, Chen YZ, Johnson KR and Fan W. In Vitro evaluation of sequential-dependent combination between docetaxel and doxorubicin in human tumor cells. Clin. Cancer Res. 6:3766-3773, 2000. PMID: 10999771
  3. Fu, LW., Deng, LA., Pan, QC. and Fan, W. Screening and discovery of novel MDR modifiers from naturally occurring bisbenzylisoquinoline alkaloids. Anticancer Res, 21:2273-2280, 2001, PMID:11724282
  4. Huang Y and Fan W. IkB kinase activation is involved in the regulation of paclitaxel-induced apoptosis in solid tumor cells. Mol. Pharmacol. 61:105-113, 2002, PMID: 11752211
  5. Johnson KR and Fan W. Potentiation of paclitaxel cytotoxicity in the presence of 5-fluouracil, via altered expression of p53 and p21waf1/c1p1. Anticancer Res. 22:3197-3204, 2002. PMID 12530065
  6. Huang Y. Fang Y. Dziadyk J. Norris JN. Fan W. The possible correlation of the activation of NF-kB/I-kB pathway with the susceptibility of tumor cells to paclitaxel-induced apoptosis. Oncol. Res. 13:113-120, 2002. PMID: 12392159
  7. Fontaine M and Fan, W. Islet transplantation as a cure for insulin-dependent diabetes: current improvements in preserving islet cell mass and function, HBPD Int. 2:181-190, 2003. PMID: 14599964
  8. Sui M, Dziadyk J, Zhu XM and Fan W. Cell cycle dependent antagonistic interactions between paclitaxel and g-radiation in combination therapy. Clin. Cancer Res. 10:4848-4857, 2004. PMID: 15269161
  9. Dziadyk J, Zhu XM, Sui M, and Fan W. Paclitaxel-induced apoptosis may occur without a prior G2/m phase arrest. Anticancer Res. 24:27-36, 2004. PMID: 15015572
  10. Fan W, Sui M and Huang Y. Glucocorticoids selectively inhibit paclitaxel-induced apoptosis: Mechanisms and its clinical impact. Curr. Med. Chem. 11:403-411, 2004. PMID: 14965221
  11. Huang Y, Fang Y, Wu J, Dziadyk J, Zhu XM, Sui M and Fan W. Regulation of Vince alkaloid-induced apoptosis by NF-kB/IkB pathway in human tumor cells. Mol. Cancer Therap. 3: 271-277, 2004. PMID: 15026547
  12. Yang J, Deng X. Deng L. Gu H and Fan W. and Cao Y. Telomerase activation by Epstein-Barr virus latent membrane protein 1 is associated with c-Myc expression in human nasopharyngeal epithelial cells. J. Exp. Clin. Cancer Res. 23:495-506, 2004. PMID: 15595642
  13. Zhu X, Sui M. Dziadyk J. and Fan W. In vitro and in vivo evaluation tetrandrine on the reversal of P-glycoprotein-mediated drug resistance to paclitaxel. Anticancer Res. 25:1953-1962, 2005. PMID: 16158930
  14. Sui M and Fan W. Combination of g-radiation antagonizes the cytotoxic effects of vincristine and vinblastine on both mitotic arrest and apoptosis. Int. J. Radiat. Oncol. Biol. Phys.1151-1158, 2005. PMID: 15752896
  15. Sui M, Chen F, Chen Z and Fan W. Glucocorticoids interfere with the therapeutic efficacy of paclitaxel against human breast and ovarian xenograft tumors. Int. J. Cancer. 119-712-717, 2006. PMID: 16496381
  16. Sui M. Xoing X, Kraft A. and Fan W. Combination of gemcitabine antagonizes antitumor activity of paclitaxel through prevention of mitotic arrest and apoptosis. Cancer Biol. Ther., 119:712-717, 2006. PMID: 16855376
  17. Sui M, Huang Y, Park BH, Davidson NE and Fan W. Estrogen receptor alpha mediates breast cancer cells resistance to paclitaxel through Inhibition of apoptotic cell death. Cancer Res, 67: 5337-5344, 2007. PMID: 17545614
  18. Xiong, X, Sui, M, Fan, W and Kraft A. Cell-Cycle Dependent Antagonistic Interactions between Paclitaxel and Carboplatin in Combination Therapy. Cancer Biol. Ther., 6: 607-13, 2007. PMID: 17568189
  19. Wang L, Jiang Z, Sui M, Shen J, Xu C, Fan W. The potential biomarkers in predicting pathologic response of breast cancer to three different chemotherapy regimens: a case control study. BMC Cancer, 9:226-235. 2009. PMID: 19591668
  20. Liu L, Xu K, Wang H, Tan PK, Fan W, Venkatraman SS, Li L, Yang YY, Self-assembled cationic peptide nanoparticles as an efficient antimicrobial agent. Nature Nanotechnol. 4:457-463. 2009. PMID: 19581900
  21. Xu W, Xi B, Wu J, An H, Zhu J, Abassi Y, Feinstein AC, Geng B, Fan W, Wang X, and Xu X. Natural Product Derivative, Bis(4-fluorobenzyl)trisulfide Inhibits Tumor Cell Growth by Modification of ß-tubulin at Cys 12 and Suppression of Microtubule Dynamics, Mole Cancer Therap, 8:3318-3330, 2009. PMID: 19996274
  22. Wang J, Sui M and Fan W. Nanoparticles for Tumor Targeted Therapies and Their Pharmacokinetics. Current Drug Metab. 11:129-141, 2010. PMID: 20359289
  23. Song H, Yang j, Lo S, Wang Y., Fan W, Tang W, Xue J and Wang S. Nonviral Magnetofection Using Self-assembled Ternary Complexes of Cationic Magnetic Particle, Plasmid DNA and Andosomolytic Tat Peptide, Biomaterials, 31:769-778, 2010. PMID: 19819012
  24. Wang H, Xu K, Liu L, Tan JP, Chen Y, Li Y, Fan W, Wei Z, Sheng J, Yang YY, Li L. The efficacy of self-assembled cationic antimicrobial peptide nanoparticles against Cryptococcus neoformans for the treatment of meningitis. Biomaterials. 31:2874-2881, 2010. PMID: 20044131
  25. Sui M, Jiang D, Hinsch C, Fan W. Fulvestrant (ICI 182,780) sensitizes breast cancer cells expressing estrogen receptor alpha to vinblastine and vinorelbine. Breast Cancer Res Treat. 121:335-345,2010. PMID: 19626437
  26. Ma K, Hu M, Xie M, Shen H, Qiu L, Fan W, Sun H, Chen S, Jin Y. Investigation of polyethylenimine-grafted-triamcinolone acetonide as nucleus-targeting gene delivery systems. J Gene Medicine. 12:669-680. 2010. PMID: 20635325
  27. Xu K, Wang H, Liu L, Xu W, Sheng J, Fan W, Yang Y, Li L. Efficacy of CG(3)R(6)TAT nanoparticles self-assembled from a novel antimicrobial peptide for the treatment of Candida albicans meningitis in rabbits. Chemotherapy, 57:417-425, 2011, PMID: 22024735
  28. Lee AL, Wang Y, Pervaiz S, Fan W and Yang YY. Synergistic Anticancer Effects Achieved by Co-Delivery of TRAIL and Paclitaxel Using Cationic Polymeric Micelles. Macromol Biosci. 11:296-307, 2011. PMID: 21154473
  29. Lee AL, Dhillon SH, Wang Y, Pervaiz S, Fan W and Yang YY. Synergistic anti-cancer effects via co-delivery of TNF-related apoptosis-inducing ligand (TRAIL/Apo2L) and doxorubicin using micellar nanoparticles. Mol Biosyst. 7:12-1522, 2011. PMID: 21350763
  30. Sui M, Zhang H and Fan W. The Role of Estrogen and Estrogen Receptors in Chemoresistance, Current Med Chem. 18:4674-4683, 2011. PMID: 21867480
  31. Zou WB, Zheng, HL, He TC, Chang JJ, Fu, YX and Fan W.* Mesenchymal Stem Cells Mediated-Delivery of LIGHT Targets Tumors and Mobilizes Immune Cells for Tumor Control, Cancer Res.72:2980-2989, 2012. PMID 22511579
  32. Qin AJ1,Zhang Y, Han N, Mei J, Sun JZ, Fan W and Tang BZh, Preparation and self-assembly of amphiphilic polymer with aggregation-induced emission characteristics, Science China Chem. 55:772-778, 2012.
  33. Chang J, Sui M and Fan W.* Estrogen Receptor alpha Attenuates Therapeutic Efficacy of Paclitaxel on Breast Xenograft Tumors, Breast Cancer Res Treat. 134:969-980, 2012. PMID: 22374518
  34. Sui M, Zhang H, Di X, Chang J, Shen Y and Fan W.* G2 Checkpoint Abrogator Abates the Antagonistic Interaction between Antimicrotubule Drugs and Radiation Therapy. Radiotherapy and Oncology, 104:243-248, 2012. PMID: 22682751
  35. Liu L, Huang Y, Riduan SN, Gao S, Yang Y, Fan W.* and Zhang Y.* Main-chain imidazolium oligomer material as a selective biomimetic antimicrobial agent. Biomaterials.33:8625-8631, 2012. PMID: 22902059
  36. Liu SQ, Yang C, Huang Y, Ding X, Li Y, Fan W, Hedrick JL, and Yang YY. Antimicrobial and Antifouling Hydrogels Formed In Situ from Polycarbonate and Poly(ethylene glycol) via Michael Addition. Adv Materials, 24:6484-6489, 2012. PMID: 23018988
  37. Huang Y; Wiradharma N, Xu, K, Ji ZK, Sheng Bi; Li L, Yang YY and Fan W.* Cationic amphiphilic a-helical peptides against carbapenem-resistant Acinetobacter baumannii infection. Biomaterials, 33:8841-8847, 2012. PMID: 22925814
  38. Fukushima K, Tan JP, Korevaar PA, Yang YY, Pitera J, Nelson A, Maune H, Coady DJ, Frommer JE, Engler AC, Huang Y, Xu K, Ji Z, Qiao Y, Fan W, Li L, Wiradharma N, Meijer EW, Hedrick JL. Broad Spectrum Antimicrobial Supramolecular Assemblies with Distinctive Size and Shape. ACS Nano. 6:9191-9199, 2012. PMID: 22998441
  39. Chang J and Fan W. Endocrine Therapy Resistance: Current Status, Possible Mechanisms and Overcoming Strategies. Anticancer Agent Med Chem, 13:464-475, 2013. PMID: 22931419
  40. Li Y, Fukushima K, Coady DJ, Engler AC, Liu S, Huang Y, Cho JS, Guo Y, Miller LS, Tan JP, Ee PL, Fan W, Yang YY, Hedrick JL. Broad-Spectrum Antimicrobial and Biofilm-Disrupting Hydrogels: Stereocomplex-Driven Supramolecular Assemblies. Angew Chem Int Ed Engl. 52: 674-678, 2013. PMID: 23161823
  41. Jiang DH, Sui M, Zhong WY, Huang Y. and Fan W. Different Administration Strategies with Paclitaxel Induce Distinct Phenotypes of Multidrug Resistance in Breast Cancer Cells. Cancer Letters, 335:404-411, 2013. PMID: 23499896
  42. Chen C, Wang Y, Goh SSL, Yang J, Lam DH, Chouhury Y, Tay FC, DS, Tan WK, Purwanti YI, Fan W and Wang S. Inhibition of neuronal nitric oxide synthase activity promotes migration of human induced pluripotent stem cell-derived neural stem cells towards cancer cells. J. Neurochem. 126(3):318-30. 2013. PMID: 23406356
  43. Huang Y, Fu PF, Fan W. Novel Targeted Therapies to Overcome Trastuzumab Resistance in HER2-Overexpressing Metastatic Breast Cancer. Current Drug Targets, 14:889-898, 2013. PMID: 23531110
  44. Shahbazi M, Kwang TW, Purwanti YI, Fan W and Wang S. Inhibitory effects of neural stem cells derived from human embryonic stems on differentiation and function of monocyte-dendritic cells. J. Neurol Sciences, 330:85-93, 2013, PMID:23664653
  45. Huang H, Weaver A, Wu E, Gao H, Fan W, Wu M. Lipid based signaling modulates DNA repair response and survival against Klebsiella pneumoniae infection in host cells and in mice. Am J Respir Cell Mol Biol, 49:798-807, 2103. PMID:23742126
  46. Zhu D, Lam DH, Purwanti Y, Goh S, Wu C, Zeng J, Fan W and Wang S. Systemic Delivery of Fusogenic Membrane Glycoprotein-Expressing Neural Stem Cells to Selectively Kill Tumor Cells, Mol Therapy, 21:1621-1630, 2013. PMID:2375230
  47. Han N, Yang YY, Wang S, Zheng S. and Fan W. Polymer-based Cancer Nanotheranostics: Retrospectives of Multi-Functionalities and Pharmacokinetics. Current Drug Matab, 14:661-674, 2013. PMID: 23869810
  48. Tay FC, Tan WK, Goh SL, Ramachandra CJ, Lau CH, Zhu H, Chen C, Du C, Phang RZ, Shahbazi M, Fan W., and Wang S. Targeted Transgene Insertion into the AAVS1 Locus Driven by Baculoviral Vector-Mediated Zinc Finger Nuclease Expression in Human Induced Pluripotent Stem Cells. J. Gene Med, 15:384-395, 2013. PMID: 24105820
  49. Phang RZ, Tay FC. Goh CA, Tan WK, Liang Q, Chen C, Du S, Li ZD, Kang JC, Zeng J, Fan W, Toh H and Wang S. Zinc Finger Nucleas-Expressing Baculovrial Vectors Mediate Target Genome Integration of Reprogramming Facotr Genes to Facilitate the Geration of Human Induced Puripotent Stem Cells. Stem Cells Trans Med. Oct. 23, 2013 [Epub Ahead of Print] PMID: 24167318
  50. Zhu HD, Lau C, Goh S, Liang Q, Chen C, Du S, Phang RZ, Tay FC, Tan WK, Li Z, Tay JC, Fan W and Wang S. Baculoviral Transduction Facilitates TALEN-Mediated Targeted Transgene Integration and Cre/LoxP Cassette Exchange in Human-Induced Pluripotent Stem Cells. Nucl Acid Res. Aug. 13, 2013 [Epub Ahead of Print] PMID: 24167318
  51. Ong ZY, Cheng J, Huang Y, Xu K, Ji Z, Fan W. and Yang YY. Effect of Stereochemistry, Chain Length and Sequence pattern on antimicrobial properties of Short Synthetic beta-sheet Forming Peptide Amphiphiles. Biomaterials, Nov 7, 2013 [Epub Ahead of Print] PMID: 24211081
  52. Chin W, Yang C, Ng V, Huang Y, Cheng CJ, Tong Y, Coady DJ, Fan W, Hedrick J, Yang YY. Biodegradable Broad-Spectrum Antimicrobial Polycarbonates: Investigating the Role of Chemical Structure on Activity and Selectivity. Macromolecules. Nov 15, 2013 [Epub Ahead of Print]
  53. Fukushima K, Liu S, Wu H, Engler A, Coady D, Maune H, Pitera J, Nelson A, Wiradharma N, Venkataraman S, Huang Y, Fan W, Ying J, Yang YY. Supramolecular High Aspect Ratio Assemblies with Strong Antifungal Activity. Nature Commun., In Press, 2013


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