The Medical University of South Carolina   Medical Center  ·  College of Medicine ·  Directory   
Department of Pathology Banner MUSC Logo


Our Mission

To serve patients, health care providers, research scientists, scholars, and society by providing excellence and innovation in diagnostic services and educational resources in a respectful, professional and culturally diverse atmosphere.

Our Vision

To become a preeminent leader in academic anatomic and clinical pathology while translating basic science discovery to improved clinical care.



Melissa Scheiber

Ph.D. Student
Mentor: Dr. Daohong Zhou
Entered program: August, 2007

Visit the Stem Cell Injury Lab

EDUCATION:

A.S. in Medical Laboratory Technology, Indiana University Northwest, 2003
B.S. in Biology, Minor Chemistry, Indiana University Northwest, 2006

RESEARCH INTERESTS:

Breast cancer is the second most common cancer-related death among women in the United States. The majority of breast cancer-related deaths are due to tumor metastasis. Several Ets factors have been shown to be dysregulated in breast cancer. Friend leukemia virus integration 1 (Fli1) is an Ets protein that is aberrantly-expressed in retrovirus-induced hematological tumors in mice, and is found to be rearranged in human Ewing's sarcoma and related primitive neuroectodermal tumors characterized by a t(11;22)(q24;q12) translocation. Limited attention has been directed towards elucidating the potential role of Fli1 in epithelial-derived cancers, including breast cancer. Data mining, along with preliminary studies, indicate that Fli1 expression is diminished or lost in human invasive breast cancer tissue specimens. While expressed in non-transformed MCF-10A breast cells, it is absent in invasive breast cancer cell lines. Significantly, re-expression of Fli1 is associated with reduced cellular growth, migration, and invasion. Additionally, the re-expression of Fli1 in the breast cancer cell lines induces cellular senescence. Based upon these observations I hypothesize that the loss of Fli1 is a critical step for breast cancer progression. By defining the unique roles of Fli1 in breast cancer progression, this study hopes to gain invaluable insights into the basis of breast cancer progression and metastasis and potentially identify unique targets of breast cancer therapy.

HOBBIES AND OTHER INTERESTS:

  • Spending time with my fiancé doug
  • Running
  • Reading
  • Watching movies


Pathology Divisions
Anatomic Pathology
Laboratory Medicine
Research

Department of Pathology and Laboratory Medicine Chairman Dr. Steven L. Carroll
Message from the Chairman


News


Upcoming Events


Copyright 2011 MUSC Department of Pathology and Laboratory Medicine