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Stimuli-Responsive Polymer Based Nanomaterials for Targeted Drug Delivery

(Education/Training/Seminars)

February 4
12:00 pm
BEB 201
2014-01-29
Sandy Bird birdsm@musc.edu

The Center For Biomedical Imaging-Guest Lecture

Peisheng Xu, Ph.D.
Assistant Professor
Dept. of Drug Discovery and Biomedical Sciences
South Carolina College of Pharmacy
University of South Carolina

"Stimuli-Responsive Polymer Based Nanomaterials
for Targeted Drug Delivery"

Over the past two decades to enhance drug efficacy and attenuate drug side effects, nano-carriers have been developed from various types of materials. Among them, stimuli-responsive polymers have attracted the most attention due to their capacity of releasing payloads at the desired sites (tissues and cells) at a desired rate upon the trigger of stimuli (for example pH, temperature, redox potential). With the help of stimuli-responsive polymers developed in my lab, peptide, DNA, as well as hydrophobic and hydrophilic small molecules, can be formulated into nanoparticle form (nano-sting, nano-cocktail, and so on). In vitro assays show that these nanoparticles exhibit much better anticancer efficacy. In vivo animal imaging experiments confirm that nanoparticles can specifically target tumor tissue. Based on the unique properties of these nanomaterials, their potential application in Alzheimer's disease and rheumatoid arthritis treatment will also be discussed.

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