Education
Memphis State University, Bachelor of Science in Biology, 1984
University of Tennessee at Memphis, Doctor of Pharmacy, 1990 Residency Training
University of Tennessee at Memphis, Psychiatric Pharmacy, 1991
Description of Research Program
Research interests include the study of genetic and environmental factors that influence the outcome of treatment with psychoactive drugs. Current studies are directed at identifying specific drug transporters and assessing genetic factors which may influence the transport of psychostimulant and antipsychotic medications which ultimately modulate clinical effects and outcomes. Drug-drug interactions, botanical-drug interactions, and the effects of age and disease states on drug and metabolite disposition are also areas of focus. Laboratory methodology employed includes cell culture, transgenic animal studies, and drug assay development using HPLC to support pharmacokinetic studies of drug disposition (drug absorption, distribution, metabolism and elimination) in both humans and animals. Pharmacogenetic studies (the effects of inheritance on drug disposition) are conducted to characterize the genotype and/or phenotype of individual’s drug transporter proteins (e.g. P-glycoprotein) and drug metabolizing enzymes. Clinical investigations are conducted in healthy human volunteers as well as patients. Present funding is through the NIH National Institute of Child Health and Human Development (NICHD), National Institute on Drug Abuse (NIDA), National Center for Complementary and Alternative Medicine (NCCAM), Office of Dietary Supplements, and the pharmaceutical industry.
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John Markowitz, Pharm.D.