Dr. Frye is a native of Rochester, Minnesota. He received his medical degree from the University of Minnesota. Dr. Frye completed his psychiatric residency at the UCLA Neuropsychiatric Institute and a research fellowship at the National Institute of Mental Health. From 1998-2006, Dr. Frye was the Director of the UCLA Bipolar Disorder Research Program.
Dr. Frye has recently joined the Mayo Clinic as a Professor and Consultant in the Department of Psychiatry. He is the Director of the Mayo Mood Disorders Research Program and a clinical scholar in the Samuel Johnson Genomics of Addiction Program.
His clinical interests are in bipolar disorder, depression, and alcoholism with a research focus on genomics, MR spectroscopy, and neuroendocrinology of major mood disorders and alcoholism. Dr. Frye was the recipient of the Depression Bipolar Support Alliance (DBSA) Gerald Klerman Young Investigator Award in 2002. He has received research funding from NIH, The Stanley Medical Research Institute, The American Foundation for Suicide Prevention, and several pharmaceutical industries. He is an active educator having received numerous teaching awards while on faculty at UCLA and an active author publishing more than 100 papers in peer-reviewed publications such as the American Journal of Psychiatry, Journal of Affective Disorder, Journal of Clinical Psychiatry and Biological Psychiatry.