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Assistant Professor
QE219
250140
843-792-7313
QF204
843-792-7567
Cardiac injury and repair, Toxicology
wrightgl@musc.edu

Education
University of Kentucky, Bachelor of Science in Biology, 1992
Marshall University, School of Medicine, Department of Biochemistry & Molecular Biology, Doctor of Philosophy, 1998

Selected Publications
Wright G, Steenbergen C, Murphy E.  Activation of the prolyl hydroxylase oxygen-sensor results in induction of GLUT1, HO-1, NOS-2 proteins, and confers protection from metabolic inhibition to cardiomyocytes. J. Biol. Chem. 2003 May 30;278(22):20235-9

Wright G, Hasday J, Singh I, and Rogers T.  Endotoxin stress-response in cardiomyocytes: NF-kappaB activation and tumor necrosis factor-alpha expression.  Am. J. Physiol. (Heart Circ Physiol.) 2002 Mar; 282(3): H872-9

Petranka J, Wright G, Forbes RA, Murphy E. Elevated calcium in preneoplastic cells activates NF-kappa B and confers resistance to apoptosis.  J. Biol. Chem. 2001 Oct 5;276(40):37102-8.

Wright G,  Terada K, Yano M, Sergeev I,  and Mori M  Oxidative stress inhibits the mitochondrial import of preproteins and leads to their degradation. Exp. Cell Res. 2001 Feb 1;263(1):107-17.

Hanlon PR, Fu P, Wright G, Steenbergen C., Arcasoy MO, Murphy E. 
Mechanisms of erythropoietin-mediated cardioprotection during 
ischemia-reperfusion injury: role of protein kinase C and 
phosphatidylinositol 3-kinase signaling. FASEB J. 2005 
Aug;19(10):1323-5.

Wright G, Hanlon P, Amin K, Steenbergen C, Murphy E, Arcasoy MO.
Erythropoietin receptor expression in cardiomyocytes is associated
with an acute cardioprotective effect for recombinant erythropoietin
during ischemia-reperfusion injury of adult rat hearts. FASEB J. 2004
Jun;18(9):1031-3