Description of Program Research in our group is generally related to the in vitro and in vivo evaluation of antimicrobial agents and the methods used to assess their properties. More specifically, our research has focused on clinical pharmacokinetics, in vitro pharmacodynamics, antimicrobial stability, and patterns in bacterial resistance as they relate to antimicrobial usage. Selected Publications White RL, Enzweiler, KA, Friedrich LV, Wagner D, Hoban D, , JA. Comparative activity of gatifloxacin and other antibiotics against 4009 clinical isolates of Streptococcus pneumoniae in the United States during 1999-2000. Diagn Microbiol Infect Dis (in press). Bonapace CR, White RL, Friedrich LV, Bosso JA. Differences in antimicrobial drug exposure in patients with varying degrees of renal function based upon recommendations from dosing references. Pharmacotherapy (in press) White RL. Antibiotic resistance: where do the ketolides fit? Pharmacotherapy 2002;22(1 Pt 2):18S-29S Kays MB, White RL, Friedrich LV. Effect of serum from different patient populations on the serum bactericidal test. J Antimicrob Chemother. 2001;4893:417-420. White RL, Friedrich LV, Manduru M, Mihm L, Bosso J. Comparative in vitro pharmacodynamics of imipenem and meropenem against Esherichia coli, Staphylococcus aureus, and Bacteroides fragilis . Diagnostic Microbiology and Infectious Disease 2001 39:39-47. White RL, Friedrich LV, Burgess DS, Brown EW, Scott LE. Effect of removing duplicate isolates on susceptibility reports. Diagnostic Microbiology and Infectious Disease 2001; 39:251-256. |