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Professor
Cooper Endowed Chair
HO612E
250140
843-792-3420
HO602
792-4421
Cancer pharmacology, Drug Discovery
smithchd@musc.edu

Educational Background
Michigan State University, Bachelor of Science, Biochemistry, 1980
Michigan State University, Doctor of Philosophy, Biochemistry, 1984
Duke University Medical Center, Research Associate, 1986

Description of Program
The main interests of my laboratory relate to cancer pharmacology, with focus on studying the molecular mechanisms of action of established and experimental anticancer drugs and on designing and developing new drugs against novel molecular targets.  Three projects are currently in progress:  

            1)  biochemistry and pharmacology of protein lipidating enzymes;
            2)  biochemistry and pharmacology of sphingosine kinase; and
            3) mechanism-based drug discovery.  

Selected Publications
Ducker, C. E., Stettler, E. M., French, K. J., Upson, J. J. and Smith, C. D.  (2004)
Huntington Interacting Protein 14 is an oncogenic human protein : palmitoyl acyltransferase.  Oncogene, 23: 9230-9237.

Ducker, C. E., Upson, J. J., French, K. J. and Smith, C. D.  (2005) Differential roles of N-myristoyltransferase isozymes in protein myristoylation, proliferation and apoptosis.  Molec. Cancer Res., 3:  463-476.

Terracciano S., Bruno I., Bifulco G., Avallone, Smith C. D., Gomez-Paloma L. and Riccio R. (2005)  Synthesis, solution structure, and bioactivity of six new simplified analogues of the natural cyclodepsipeptide jaspamide.  Bioorganic & Medicinal Chemistry, 13: 5225-5239.

Sharma, A., Trivedi, N. R., Zimmerman, M. A., Tuveson, D. A., Smith, C. D. and Robertson, G. P.  (2005) Mutant ^V599EB-Raf regulates growth and vascular development of malignant melanoma tumors.  Cancer Res. 65:  2412-2421.

French, K. J., Upson, J. J., Smith, S. N., Zhuang, Y., Yun, J. K. and Smith, C. D. (2006)  Antitumor Activity of Sphingosine Kinase Inhibitors.  J. Pharm. Exp. Therap., in press.

Maines, L. W., French, K. J., Wolpert, E. B., Antonetti, D. A. and Smith, C. D.  (2006) Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells:  Implications for angiogenic ocular diseases.  Invest Opth Visual Sci, in press.

Ducker, C. E., Griffel, L. K., Smith, R. A., Keller, S. N., Zhuang, Y., Xia, Z., Diller, J. D. and Smith, C. D.  (2006) Discovery and characterization of inhibitors of human palmitoyl acyltransferases.  Molec. Cancer Therapeut., in press.