Dr. Ken Patrick

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Kennerly S. Patrick, PhD

	Title:	Professor
	Office:	QF221A
	PO Box:	250140
	Office Phone:	843-792-8429
	Research Area:	Medicinal Chemistry
	E-mail:	patrickk@musc.edu
Education University of North Carolina, Bachelor of Science; Pharmacy, 1974 University of Iowa, Doctor of Philosophy; 1978
Description of Research Program Drug design, metabolism and mass spectrometric analysis: The influence of drug bioavailability/metabolism on clinical response is being explored through the synthesis and pharmacological evaluation of metabolites and through the application of gas chromatography-mass spectrometry to therapeutic drug monitoring. The relationship between drug stereochemistry and biological activity is being investigated following analytical and preparative scale isomeric resolutions. The design and synthesis of psychotherapeutic drug candidates is being directed at specific neurotransmitter receptor subtypes and at overcoming biological barriers. Selected Publications Patrick, K.S., Gonzalez, M.A. Straughn, A.B. and Markowitz, J.M.: New methylphenidate formulations for the treatment of attention-deficit/hyperactivity disorder, Expert Opin. Drug Deliv., 2 (1): 121-143, 2005. Patrick, K.S., Williard, R.L.,VanWert, A.L., Dowd, J.J., Oatis, J.E. and Middaugh, L.D.: Synthesis and pharmacology of ethylphenidate enantiomers: The human transesterification Metabolite of methylphenidate and ethanol. J. Med. Chem, 48: 2876-2881, 2005. Rahmaniyan, M., Patrick, K.S. and Bell, N.H.: Characterization of recombinant CYP2C11: A vitamin D 25-hydroxylase and 24-hydroxylase, Am. J. Physiol.: Endocin. Metab., 288: E753-E760, 2005. Gupta, R.P., He, Y.A., Patrick, K.S., Halpert, J.P. and Bell, N.H.: CYP3A4 is both a vitamin D-24-hydroxylase and a vitamin D-25-hydroxylase: Analysis of structure function by site-directed mutagenesis. J. Clin. Endocrinol. Met., 90 (2): 1210-1219, 2005. Njoku, C.J, Patrick, K.S. Ruiz Jr P and Oates, J.C.: Inducible nitric oxide synthase inhibitors reduce systemic oxidant stress in murine proliferative lupus nephritis. J. Invest. Med., 53 (7): 347-352, 2005. Donovan, J.L.,DeVane, C.L., Chavin, K.D.., Oates, J.C., Njoku, C.J., Patrick, K.S., Fiorini, R.N. and Markowitz, J.S.: Oral administration of a decaffeinated green tea (Camellia sinensis) extract did not alter urinary 8-epi-prostaglandin F₂_a, a biomarker for lipid peroxidation, J. Pharmacy and Pharmacol. 57: 1-5, 2005. Markowitz, J.S., DeVane, C.L., Pestreich, L.K., Patrick, K.S. and Muniz, R.: Comprehensive in vitro screening of d-, l- and dl-methylphenidate: Theoretical implications for the treatment of attention-deficit/hyperactivity disorder, J. Child Adolesc. Psychopharmacol, in press 2006. Patrick, K.S. : Dexmethylphenidate extended-release; Guest commentary. Drugs (Adis Drug Profile) 66(3): 669-670, 2006. Zhu, H-J., Wang, J-S., DeVane, C.L., Williard, R.L., Donovan, J.L., Middaugh, L.D., Gibson, B.B., Patrick, K.S., and Markowitz, J.S.: The role of the polymorphic efflux transporter P-glycoprotein on the brain accumulation of d-methylphenidate and d-amphetamine, Drug Metab. Dispos., 34 (7): 1116-1121, 2006. Williard, R.L, Middaugh, L.D, Zhu, H. and Patrick, K.S.: Methylphenidate and its ethanol transesterification metabolite ethylphenidate: Brain disposition, monoamine transporters and motor activity, Behav. Pharmacol., in press 2006. Patrick, K.S., Straughn, A.B., DeVane,C.L., Minhinnett, R.R., Janis, G.C., Malcolm, R.J. and Markowitz, J.S.: Influence of ethanol and gender on methylphenidate pharmacokinetics and pharmacodynamics, Clin. Pharmacol. & Ther., in press 2006.

Contact Information
Department of Pharmaceutical Sciences
280 Calhoun Street
Charleston SC 29425
Sandy Spence 843-792-3117