Proteomics Facility Projects

The MUSC Nephrology Proteomics Facility participates in projects initiated by the directors as well as in collaboration with other investigators.  A primary function of the facility is biomarker discovery and validation. Other projects involve describing the pathophysiology of renal and other diseases and of organisms that affect the environment.

This NIDDK-funded project is currently enrolling patients that develop AKI after cardiac surgery at five sites.

Acute kidney injury (AKI) after surgery occurs in about 7% of patients and is… (more details).

Prognostic markers in postoperative acute kidney injury

This Department of Veterans Affairs-funded project is using samples obtained from the VA Diabetes Trial to identify combinations of .urine proteins that predict worsening of diabetic nephropathy over a six year period.

Predictive biomarkers in diabetic nephropathy

MUSC Nephrology Proteomics Facility

Improvement in 2D gel technologies

This NHLBI-funded project is identifying and improving methodologies to improve the capacity of 2D gel electrophoresis. 2DE is a high resolution technique but has difficulty resolving and visualizing certain types of protein. This project is part of the larger, MUSC cardiovascular proteomics center.

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