|
Kennerly
S. Patrick, Ph.D.
|
|
| Title: |
Professor |
| Department: |
Pharmaceutical
Sciences |
| Office: |
QF221A |
| PO
Box: |
250140 |
| Office
Phone: |
843-792-8429 |
| Lab: |
QF216 |
| Lab
Phone: |
843-792-8429 |
| Research Area: |
Medicinal
Chemistry |
| E-mail: |
patrickk@musc.edu |
|
Educational Background
University of North Carolina, Bachelor of Science; Pharmacy, 1974
University of Iowa, Doctor of Philosophy; 1978 |
Description
of Research Program
Drug design,
metabolism and mass spectrometric analysis: The influence of drug bioavailability/metabolism
on clinical response is being explored through the synthesis and pharmacological
evaluation of metabolites and through the application of gas chromatography-mass
spectrometry to therapeutic drug monitoring. The relationship between
drug stereochemistry and biological activity is being investigated following
analytical and preparative scale isomeric resolutions. The design
and synthesis of psychotherapeutic drug candidates is being directed at
specific neurotransmitter receptor subtypes and at overcoming biological
barriers.
Selected
Publications
Markowitz JS,
Straughn AB, Patrick KS, DeVane, CL, Pestrich L, Wang Y and Muniz
R: Bioavailability of Two Modified-Release Methylphenidate Formulations:
Ritalin LA versus Concerta. Clin. Pharmacokin., 42: 393-401, 2003.
Markowitz JS,
Patrick KS: Pharmacokinetic and pharmacodynamic drug interactions
in the treatment of attention-deficit hyperactivity disorder. Clin. Pharmacokin.,
40: 753-772, 2001.
Markowitz JS,
DeVane CL, Boulton DV, Nahas Z, Risch SC, Diamond F, Patrick KS:
Ethylphenidate formation in human subjects after the administration of
a single dose of methylphenidate and ethanol. Drug Metab. Dispos., 28:
620-624, 2000.
Meyer MC, Straughn
AB, Jarvis EJ, Patrick KS, Pelson FR, Williams RL, Chen M-L, Shah
VP: Bioequivalence of methylphenidate immediate-release tablets using
a replicated study design. Pharmaceut. Res., 17:381-384, 2000.
Singh SK, Patrick
KS: Synthesis of 7-hydroxythioridazine and 7-hydroxysulforidazine.
J. Heterocyclic Chem., 29 : 995-999, 1992.
Patrick KS,
Caldwell, RW, Ferris, RM, Breese GR: Pharmacology of the enantiomers of
threo-methylphenidate. J. Pharmacol. Exper. Ther., 241:152-158, 1987.
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Last updated
9/23/03 by Kathy Chessman.
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