John A. Bosso, Pharm.D., FCCP, BCPS
	Professor and Chair Department of Clinical Pharmacy and Outcome Sciences Certifications: BCPS, Added Qualifications in ID Office: QE222 PO Box: 250142 Office Phone: 843-792-8501 Lab: QF220 Lab Phone: 843-792-4899 Practice Area:  Infectious Diseases Research Area:  Antimicrobial Agents Pager: 12045 E-mail: bossoja@musc.edu CV

Description of Research Program
Research in our group is generally related to the in vitro and in vivo evaluation of antimicrobial agents and the methods used to assess their properties.  More specifically, our research has focused on clinical pharmacokinetics, in vitro pharmacodynamics, antimicrobial stability, and patterns in bacterial resistance as they relate to antimicrobial usage.

Selected Publications
Bonapace CR, Bosso JA, Friedrich LV, White RL. Comparison of Methods of Interpretation of Checkerboard Synergy Testing. Diagn Microbiol Infect Dis 2002;44:363-6.

Bonapace CR, Friedrich LV, Bosso JA, White RL,. Determination of antibiotic effect in an in vitro pharmacodynamic model: comparison with an established animal model of infection. Antimicrob Agents Chemother 2002;46:3574-9.

White RL, Enzweiler, KA, Friedrich LV, Wagner D, Hoban D, Bosso JA. Comparative Activity of Gatifloxacin and Other Antibiotics Against 4009 Clinical Isolates of Streptococcus pneumoniae in the United States During 1999-2000. Diagn Microbiol Infect Dis 2002;43:207-17.

White RL, Friedrich LV, Manduru M, Mihm LB, Bosso JA. Comparative in vitro pharmacodynamics of imipenem and meropenem against ATCC strains of Escherichia coli, Staphylococcus aureus and Bacteroides fragilis. Diagn Microbiol Infect Dis 2001;39:39-47.

White RL, Friedrich LV, Mihm LB, Bosso JA. Assessment of the relationship between antimicrobial usage and susceptibility: Differences between the hospital and specific patient care areas. Clin Infect Dis 2000;31:16-23.