Xiaofeng Yang, M.D., Ph.D.
Postdoctoral Fellow
M.D., Ph.D. - Fourth Military Medical University, Xi'an, China
Tel: 843-792-3395
Fax: 843-792-1066
yangxiao@musc.edu
Receptor Mechanisms mediating bradykinin actions to increase outflow facility within eyes.
My current research focuses on determining the time and dose-response relationship of bradykinin-induced increase in outflow facility in perfused anterior segments. The studies will explore the early cell signaling events involved in bradykinin effects on MMP and TIMP secretion through investigating the effects of bradykinin on the secretion of MMP-1, -2, 3 and -9 and TIMP effects. Another aim of the investigation includes the interaction between bradykinin and PGE2 in increasing outflow facility in perfused anterior segments and the mechanism by which bradykinin enhances PGE2 signaling in trabecular meshwork cells.
Selected Publications
Boackle RJ, Nguyen QL, Leite RS, Yang X and Vesely J. Complement-coated antibody-transfer (CCAT); serum IgA1 antibodies intercept and transport C4 and C3 fragments and preserve IgG1 deployment (PGD). Mol Immunol 43(3):193-201, 2006 (Epub 2005 Mar 5).
Xiangming L, Xiaofeng Y, Yunyun J and Jing L. A novel HBV DNA vaccine based on T cell epitopes and its potential therapeutic effect in HBV transgenic mice. International Immunology 17(10):1293-302, 2005.
Meng A, Luberto C, Meier P, Bai A, Yang X, Hannun YA and Zhou D. Sphingomylin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells. Exp Cell Res 292:9385-9392, 2004.
