- Lauren E. Ball, Ph.D.
- Joe B. Blumer, Ph.D.
- Warren Davis Jr., Ph.D.
- Scott Eblen, Ph.D.
- Perry V. Halushka, M.D., Ph.D.
- John D. Hildebrandt, Ph.D.
- Jennifer S. Isaacs, Ph.D.
- Daniel R. Knapp, Ph.D.
- David T. Kurtz, Ph.D.
- Stephen M. Lanier, Ph.D.
- Carola A. Neumann, M.D.
- John E. Oatis, Ph.D.
- Steven A. Rosenzweig, Ph.D.
- Kevin L. Schey, Ph.D.
- Kenneth D. Tew, Ph.D., D.Sc.
- Thomas Walle, Ph.D.
- Michael J. Wargovich, Ph.D.
- Jerry G. Webb, Ph.D.
Kevin L. Schey, Ph.D.
Professor
Cell and Molecular PharmacologyDirector, MUSC Biomolecular Mass Spectrometry Facility
Project Leader, Intact Protein-Based Proteomics Analysis, MUSC Proteomics Center
Ph.D., Purdue University, 1989
scheykl@musc.edu
Tel: 843-792-4367
Fax: 843-792-2475
Schey Lab
Lab Retreat
Sabbatical Photos
Development and Application of Mass Spectrometry to Pharmacology
The focus of the Schey lab is on the use of mass spectrometry in proteomics and in protein structure determination. The lab is interested in both method/instrument development as well as applications of state-of-the-art technology. Specific projects are focused on lens membrane protein structure in aging and cataractogenesis, shrimp & oyster innate immunity, and tandem mass spectrometry of intact proteins. These areas of emphasis involve proteomics studies of the human lens and shrimp/oyster tissues as well as determination of posttranslational modifications, and protein-protein interactions. Other areas of application include studies of signal transduction complexes, ocular proteomics (in glaucoma and retinal neovascularization), and cardiovascular proteomics.
New Initiative in MALDI Tissue Imaging
Selected Publications | Additional Publications
Thibault DB, Gillam CJ, Han J, Schey KL. MALDI Tissue Profiling of Integral Membrane Proteins from Ocular Tissues. J. Amer. Soc. Mass Spectrom., in press.
Grey AC and Schey KL. Distribution of Bovine and Rabbit Lens α-crystallin products by MALDI Imaging Mass Spectrometry. Molecular Vision 14:171-179, 2008.
Lindsey Rose KM, Wang Z, Magrath GN, Hazard ES, Hildebrandt JD and Schey KL. Aquaporin 0-Calmodulin Interaction and the Effect of AQP0 Phosphorylation. Biochemistry 47:339-47, Jan 8, 2008.
Liu Z and Schey KL. Fragmentation of Multiply-Charged Intact Protein Ions Using MALDI TOF-TOF Mass Spectrometry. J. Amer. Soc. Mass Spectrom. 19:231-238, 2008. (Epub ahead of print June 2007.)
Ouvry Patat SA and Schey KL. Characterization of antimicrobial histone sequences and posttranslational modifications by mass spectrometry. J. Mass Spectrom. 42:664-674, 2007.
Xue G, Itoh N, Schey KL, Li Y, Cooper RK, La Peyre JF. A New Lysozyme from the Eastern Oyster (Crassostrea virginica) Indicates Adaptive Evolution of i-Type Lysozymes in Bivalve Mollusks. Cell. Mol. Life Sci. 64:82-95, 2007.
Rose KLM, Gourdie RG, Prescott AR, Quinlan RA, Crouch RK, Schey KL. The C-terminus of Lens Aquaporin 0 Interacts with the Cytoskeletal Proteins Filensin and CP49. Invest. Ophthalmol. Vis. Sci. 47:1562-70, 2006.
Lindsey ML, Goshorn DK, Comte-Walters S, Hendrick JW, Hapke E, Zile MR, Schey KL. A Multidimensional Proteomic Approach to Identify Hypertophy-Associated Proteins. Proteomics 6:2225-35, 2006.
Liu Z and Schey KL. Optimization of a MALDI TOF-TOF Mass Spectrometer for Intact Protein Analysis, J. Amer. Soc. Mass Spectrom. 16:482-90, 2005.
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