Postdoctoral Position(s) are available to study the role of insulin-like growth factors in tumorigenesis and age-related macular degeneration. Experience in molecular and cellular biology and/or protein characterization required for investigations into the design of inhibitors of specific protein:protein interactions in IGF signaling. Tissue-specific "knock-in" and "knock-out" mouse studies will also be carried out.
The following projects are currently ongoing:
Photoaffinity labeling of the IGF-binding site on recombinant IGFBP-2, IGFBP-5 and IGFBP-3. These studies are geared toward defining the sites of IGF-1 contact on the IGF binding proteins.
Determination of the mechanism by which the IGFBPs inhibit IGF action. Using truncation and deletion mutants of the IGFBPs, we will determine the role of the domains on the IGFBPs in ligand binding and blockade of receptor interactions.
Molecular modeling of the interaction between IGF-1 and IGFBP-2.
Identification of novel peptides that interact with the IGFBP-binding domain of IGF-1 using phage display technology.
Molecular mechanisms of mesangial cell regulation of IGFBP-2 biosynthesis and secretion in the context of hyperglycemia.
Role of the IGF system in modulating the wound healing phenotype in diabetic mesangial cells. Emphasis will be placed on determining the role of low molecular weight GTP-binding proteins and cell shape changes.
Regulation of vascular endothelial cell growth factor expression by the IGFs.
IGF-1 receptor signal transduction to the nucleus. These studies will include analysis of the role of nuclear tyrosine phosphorylation on IGF-1 R receptor signaling.
Please send or e-mail CV and names of three references to:
Steven A. Rosenzweig, Ph.D.
Department of Cell and Molecular Pharmacology
Medical University of South Carolina
173 Ashley Avenue
P.O. Box 250505
Charleston, SC 29425
Fax: 843-792-2475
Phone: 843-792-5841
e-mail:rosenzsa@musc.edu