- Lauren E. Ball, Ph.D.
- Joe B. Blumer, Ph.D.
- Warren Davis Jr., Ph.D.
- Scott Eblen, Ph.D.
- Perry V. Halushka, M.D., Ph.D.
- John D. Hildebrandt, Ph.D.
- Jennifer S. Isaacs, Ph.D.
- Daniel R. Knapp, Ph.D.
- David T. Kurtz, Ph.D.
- Stephen M. Lanier, Ph.D.
- Carola A. Neumann, M.D.
- John E. Oatis, Ph.D.
- Steven A. Rosenzweig, Ph.D.
- Kevin L. Schey, Ph.D.
- Kenneth D. Tew, Ph.D., D.Sc.
- Thomas Walle, Ph.D.
- Michael J. Wargovich, Ph.D.
- Jerry G. Webb, Ph.D.
Daniel R. Knapp, Ph.D.
Distinguished University Professor
Professor of PharmacologyAdjunct Professor of Bioengineering
Clemson University
Director, MUSC Proteomics Center
knappdr@musc.edu
Tel: 843-792-5830
Fax: 843-792-2475Mass Spectrometry, Protein Structure and Function, Proteomics
The major focus of this laboratory is proteomics, defined as the study of the repertoire of proteins expressed in a system. Work is underway on development of new technology for proteomic analysis using microfluidic devices and new modes of ionization for mass spectrometry analysis. The laboratory includes a cleanroom and other facilities for microfabrication as well as vacuum deposition systems for preparation of nanostructured thin films. Another project is the development of a new approach to dealing with the very large range of protein concentrations encountered in proteomic analysis. The focus of applications is upon cerebrospinal fluid proteomics as an approach to probing changes in the central nervous system.
Selected Publications | Additional Publications
R Nayak and DR Knapp. Laser desorption ionization from porous alumina thin films. Analytical Chemistry 79:4950-4956, 2007.
KS Shores and DR Knapp. Assessment approach for evaluating high abundance protein depletion methods for cerebrospinal fluid (CSF) proteomic analysis. J Proteome Research 6(9):3739-3751, 2007.
A Sen, J Darabi, and DR Knapp. Simulation and parametric study of a novel multi-spray emitter for ESI-MS applications. Microfluidics and Nanofluidics 3:283-298, 2006.
KW Ro, R Nayak, and DR Knapp. Monolithic media in microfluidic devices for proteomic analysis. Electrophoresis 27:3547-3558, 2006.
J Liu, KW Ro, R Nayak, and DR Knapp. Monolithic column plastic microfluidic device for peptide analysis using electrospray from a channel opening on the edge of the device. Intl Journal of Mass Spectrometry 259:65-72, 2006.
KW Ro, J Liu, and DR Knapp. Plastic microchip HPLC-MALDI/MS using monolithic columns. Journal of Chromatography A 1111:40-47, 2006.
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