- Lauren E. Ball, Ph.D.
- Joe B. Blumer, Ph.D.
- Warren Davis Jr., Ph.D.
- Scott Eblen, Ph.D.
- Perry V. Halushka, M.D., Ph.D.
- John D. Hildebrandt, Ph.D.
- Jennifer S. Isaacs, Ph.D.
- Daniel R. Knapp, Ph.D.
- David T. Kurtz, Ph.D.
- Stephen M. Lanier, Ph.D.
- Carola A. Neumann, M.D.
- John E. Oatis, Ph.D.
- Steven A. Rosenzweig, Ph.D.
- Kevin L. Schey, Ph.D.
- Kenneth D. Tew, Ph.D., D.Sc.
- Thomas Walle, Ph.D.
- Michael J. Wargovich, Ph.D.
- Jerry G. Webb, Ph.D.
Perry V. Halushka, M.D., Ph.D.Professor
Cell and Molecular PharmacologyDean, College of Graduate Studies
Director, Medical Scientist Training Program
Member, Cancer Cell Signaling Program
Hollings Cancer Center
Ph.D., M.D., University of Chicago, 1967, 1970
halushpv@musc.edu
Tel: 843-792-3012
Fax: 843-792-6590Molecular Characterization and Regulation of Thromboxane A2 Receptors in Health and Disease
The long term objective of our research program is to determine the role of thromboxane A2 receptors in disease processes with a particular emphasis in cancer. In collaboration with Drs. Omar Moussa and Dennis Watson we have found that there is an over-expression of the beta isoform of thromboxane A2 receptors in bladder cancer tissue and cell lines. The over-expression is associated with a poorer prognosis in patients with bladder cancer. Current studies are focused on determining the mechanisms for: 1) the over-expression of the receptors and 2) the signaling pathways involved in the oncogenic effects. The observations made in these studies may have wider applicability to other cancers.
Selected Publications | Additional Publications
Moussa O, Riker JM, Klein J, Fraig M, Halushka PV, and Watson DK. 2007. Inhibition of thromboxane synthase activity modulates bladder cancer cell responses to chemotherapeutic agents. Oncogene. July 2, 2007 epub.
Moussa O, Yordy HS, Abol-Elenin H, Sinha D, Bissada NK, Halushka PV, Ghoneim MA, and Watson DK. 2005. Prognostic and functional significance of thromboxane synthase gene over-expression in invasive bladder cancer. Cancer Research 65:11581-11587.
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