- Lauren E. Ball, Ph.D.
- Joe B. Blumer, Ph.D.
- Warren Davis Jr., Ph.D.
- Scott Eblen, Ph.D.
- Perry V. Halushka, M.D., Ph.D.
- John D. Hildebrandt, Ph.D.
- Jennifer S. Isaacs, Ph.D.
- Daniel R. Knapp, Ph.D.
- David T. Kurtz, Ph.D.
- Stephen M. Lanier, Ph.D.
- Carola A. Neumann, M.D.
- John E. Oatis, Ph.D.
- Steven A. Rosenzweig, Ph.D.
- Kevin L. Schey, Ph.D.
- Kenneth D. Tew, Ph.D., D.Sc.
- Thomas Walle, Ph.D.
- Michael J. Wargovich, Ph.D.
- Jerry G. Webb, Ph.D.
Warren Davis, Jr., Ph.D.Assistant Professor
Cell and Molecular PharmacologyPh.D., University of Pennsylvania, 1998
Postdoctoral Fellow, Fox Chase Cancer Center
davisw@musc.edu
Tel: 843-792-5825
Fax: 843-792-2475ATP-Binding Cassette Transporters and Cholesterol Homeostasis
Dr. Davis' focus has been investigating the function of the ATP-Binding Cassette Transporter-2 (ABCA2), and its role in the trafficking of low-density lipoprotein-derived free cholesterol (LDL-FC).
Future work will examine the role of the transporter in tumor cells manifesting dysregulation of the LDL receptor (e.g. prostate carcinoma) as well as the mechanisms responsible for the coordinated expression of ABCA2 and other sterol-responsive genes in the maintenance of cholesterol homeostasis.
Selected Publications | Additional Publications
Davis W. Jr., Boyd J.T., Ile K.E. and Tew K.D. Human ATP-binding cassette transporter-2 (ABCA2) positively regulates low-density lipoprotein receptor expression and negatively regulates cholesterol esterification in Chinese hamster ovary cells. Biochim Biophys Acta 1683(1-3):89-100, 2004.
Ile K.E., Davis W. Jr., Boyd J.T., Soulika A.M. and Tew K.D. Identification of a novel first exon of the human ABCA2 transporter gene encoding a unique N-terminus. Biochim Biophys Acta 1678:22-32, 2004.
Davis W. Jr., Chen Z.J., Ile K.E. and Tew K.D. Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors. Nucleic Acids Research 31:1097-1107, 2003.
