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Basic Biomedical Sciences - Students are familiarized with departmental doctoral training programs. Elements of this course include: foundations of biomedical sciences; essential scientific practices; laboratory rotations; technology updates; important unanswered questions in the biomedical sciences; three-week elective; journal club and seminars. 15 hours, Fall and Spring. All Faculty.
Medical Pharmacology - Presents important concepts and principles regarding the proper therapeutic application of all major drug categories. Familiarizes the student with the history, source, physical, and chemical properties of drugs; their biochemical, physiological, and toxicological effects; and their mechanisms of absorption, distribution, action, biotransformation, and excretion. Emphasis is placed on problem solving through a critical evidence-oriented approach. 9 hours, Spring. Webb.
Pharmacy Pharmacology - Presents important concepts and principles regarding the proper therapeutic application of all major drug categories. Familiarizes the student with the history, source, physical, and chemical properties of drugs; their biochemical, physiological, and toxicological effects; and their mechanisms of absorption, distribution, action, biotransformation, and excretion. Emphasis is placed on mechanisms of drug action and pharmacokinetics. 8 hours, Fall/Spring. S. Berger and Kurtz.
Dental Pharmacology - Demonstrates general principles of drug action, efficacy, and safety of pharmacologic agents and covers the application of these principles to the major drug classes. 4 hours, Spring. Kurtz.
Principles of Pharmacology - This course develops an understanding of the principles required for conducting research studies involving the use of pharmacological agents as tools for understanding basic biological processes. The course covers basic principles of receptor theory, analysis of dose-response relationships, data interpretation, and the relationship between the chemistry of biological molecules and their cellular actions. These principles are developed in relation to departmental research tracks in signal transduction /cancer biology, functional genomics, cardiovascular biology and drug metabolism/toxicology. The course will impart an essential understanding of how pharmacological agents interact with living systems and how such actions are examined from an experimental point of view. 4 hours, Fall. Rosenzweig and Faculty.
Mass Spectrometry and Proteomics - This course will examine basic principles of mass spectrometry as well as instrumentation and applications with an emphasis on the analysis of biomolecules. In addition, the course will provide detailed coverage of proteomics analysis including techniques, quantitative strategies, applications and bioinformatics analysis approaches. 3 hours, Spring. Schey.
Advanced Topics in Cell Signaling - The vast majority of human diseases involve defects in cellular communication and therapeutic intervention often targets molecules involved in cell signaling. This course will dissect signaling cascades and their alterations in disease states addressing cutting edge issues. The course will be offered each Fall with the theme rotating among three broad topics: Cell Signaling in the Cardiovascular System, Cell Signaling in Cancer, Cell Signaling in the Nervous System. Specific diseases under these broader categories will be selected by faculty or students and then each disease will be dissected by one of the course participants (oral/written) to understand how signaling events are affected, how signaling dysfunction contributes to the onset or progression of the disease and how signaling events might be targeted in a therapeutic attack on the disease. The course is intended for advanced graduate and postgraduate students and will be coordinated with the Cell-Signaling Seminar Series (organized through the Department of Pharmacology) held each Fall, thus allowing seminar speakers to participate in the course. 3 hours, Fall. Kurtz.
PCOL 742. Development of Molecular Cancer Therapies: From Bench to Bedside. - This course is organized into 7 sections.
1) Introduction to cancer causation, initiation, molecular basis, and genetics. This section will survey in detail the molecular basis of cancer causation and genetic origin.
2) Cancer molecular pathology and diagnosis. The molecular and proteomic basis for cancer detection and diagnosis will be covered in theory and with practical demonstrations.
3) Cancer imaging. Spectroscopy, Pet, CT and Optical Therapy and practice. The physics of cancer imaging will be explained and demonstrated with real time examples from both research and clinical environments.
4) Immunology of cancer. Subject matter includes discussion of both innate and adaptive immunity to cancer, immunotherapy, and vaccine therapy.
5) Drug therapy. Subject matter will range from use of radiation and chemotherapy, both singly and in combination with Gene Therapy approaches, to new small molecule drugs and mechanisms of action and of drug resistance.
6) Cancer epidemiology, prevention and control. This section will present cancer incidence, mortality and survival statistics coupled with up-to-date information on life style, diet and prevention studies for prevention and control of cancer.
7) Translational research in which the students will be exposed, by surgical and medical practitioners, to actual patient care situations. Students will observe therapy in the clinical setting with lectures on modern medical-surgical techniques and approaches for treatment of cancer.
Norris and Tew. Prerequisite to T32 Cancer Therapeutics training grant.
Research - Variable hours. All Faculty
Thesis - Variable hours. All Faculty
Dissertation - Variable hours. All FacultyFurther information regarding the program may be obtained by writing to the Director of the Graduate Training Program, Steven A. Rosenzweig, Ph.D., in the Department of Cell and Molecular Pharmacology.
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