Yong Wang, M.D., Ph.D.

Assistant Professor, Department of Pathology & Laboratory Medicine
Office: Walton Research Building Room 401
Address: 39 Sabin Street, Charleston, SC 29425
Phone: (843) 792-9983
Fax: (843) 792-0368

EDUCATION:

M.D., 1990, Chongqing Medical University
Ph.D., 2001, Peking Union Medical College
PostDoctoral Fellow, 2002-2006 Medical University of South Carolina

RESEARCH INTERESTS:

Stem Cell Biology
MicroRNAs and Lung Cancer
Development of Novel Radiosensitizers for Cancer Therapy

FUNDING:

Research programs in the laboratory are supported in part by NIH grants R21 HL106451, P30 CA138313, and U19 AI067770.

OTHER EXPERIENCE AND PROFESSIONAL MEMBERSHIPS:

2003 - present Member, American Society of Hematology
2004 - present Member, Radiation Research Society
2004 – present Member, International Society for Experimental Hematology
2008 - present Member, Hollings Cancer Center
2008 - present Reviewer for Biochem Pharmacol, and J Radiat Res

AWARDS AND HONORS:

1996 Governor’s Award for Science and Technology Excellence, Sichuan Province. Chengdu, China
2000 - Excellent Doctorate Scholarship, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC). Beijing, China
2004-2006 - Scholars-in-Training (SIT) Award, Radiation Research Society
2006 - Travel grant, International Society for Experimental Hematology
2007 - Young Investigator Award, 13th International Congress of Radiation Research, San Francisco, CA
2008 - MUSC Nominee for the Ellison Medical Foundation New Scholar Award

SELECTED PEER-REVIEWED PUBLICATIONS:

1. Wang Y, Li G, Zheng GG, Song YH, Wu KF. Detection and sequencing analysis of IL-18 expression in J6-1 leukemic cells. Leuk Res 2001; 25: 273-74. PMID: 11261420.
2. Wang Y, Zheng GG, Wu KF, Li G and Rao Q. Construction of macrophage colony-stimulating factor receptor DNA vaccine. Haematologica 2001; 86: 1219-20. PMID: 11694409.
3. Wang Y, Li G, Rao Q, Wu KF. Expression of interleukin-18 in human leukemia cell lines and studies on its clinical significance. Zhonghua Yi Xue Za Zhi PMID: 11798931.
4. Zhang B, Wang Y, Zheng GG, Ma XT, Li G, Wu KF. Clinical significance of IL-18 gene over-expression in AML. Leuk Res 2002; 26: 887-92. PMID: 12163048.
5. Meng A, Wang Y, Van Zant G, Zhou D. Ionizing radiation and busulfan induce premature senescence in murine bone marrow hematopoietic cells. Cancer Res 2003; 63: 5414-9. PMID: 14500376.
6. Meng A, Wang Y, Brown SA, Van Zant G, Zhou D. Ionizing Radiation and Busulfan Inhibit Murine Bone Marrow Cell Hematopoietic Function via Apoptosis Dependent and Independent Mechanisms. Exp Hematol, 31:1348-1356, 2003. PMID: 14662344.
7. Meng A, Yu T, Chen G, Brown SA, Wang Y, Thompson JS, Zhou D. Cellular Origin of IR-Induced NF-kB Activation in vivo and Role of NF-kB in Ionizing Radiation-Induced Lymphocyte Apoptosis. Int J Radiation Biol, 79:849-861, 2003.
8. Bai A, Meier GP, Wang Y, Luberto C, Hannun YA, Zhou D. Prodrug modification increases D609 chemical stability and cytotoxicity against U937 leukemia cells. J Pharmacol Exp Ther 2004; 309: 1051-9. PMID: 14960662.
9. Wang Y, Meng A, Zhou D. Inhibition of phosphatidylinostol 3-kinase uncouples H2O2-induced senescent phenotype and cell cycle arrest in normal human diploid fibroblasts. Exp Cell Res 2004; 298:188-96. PMID: 15242773.
10. Wang Y, Meng A, Lang H, Brown SA, Konopa JL, Kindy MS, Schmiedt RA, Thompson JA, Zhou D. Activation of nuclear factor kappa B in vivo selectively protects the murine small intestine against ionizing radiation-induced damage. Cancer Res 2004; 64: 6240-6. PMID: 15342410.
11. Probin V, Wang Y, Bai A, and Zhou D. Busulfan selectively induces cellular senescence but not apoptosis in WI38 fibroblasts via a p53-independent but Erk-p38 MAPK-dependent mechanism. J Pharmacol Exp Ther 2006; 319: 551-60. PMID: 16882877. (Abstarct)
12. Wang Y, Schulte BA, Zhou D. Hematopoietic stem cell senescence and long-term bone marrow injury. Cell Cycle 2006; 5:35-38. PMID: 16319536.
13. Wang Y, Probin V and Zhou D. Cancer therapy-induced residual bone marrow injury- Mechanisms of induction and implication for therapy. Curr Cancer Ther Rev 2006; 2: 271-9.
14. Wang Y, Schulte BA, Larue AC, Ogawa M and Zhou D. Total body irradiation selectively induces murine hematopoietic stem cell senescence. Blood 2006; 107:358-66. PMCID: PMC1895367.
15. Probin V, Wang Y and Zhou D. Busulfan-induced senescence is dependent upon ROS production upstream of the MAPK pathway. Free Radic Biol and Med 2007; 42: 1858-65. PMCID: PMC193987.
16. Foster K, Wang Y, Zhou D, Wright C. Dependence on PI3K/Akt signaling for malignant rhabdoid tumor cell survival. Cancer Chemother and Pharmacol 2009; 63 (5): 783-91. PMID: 18641990.
17. Johnso SM, Torrice M, Bell JF, Monahan KB, Jiang Q, Wang Y, Ramsey MR, Jin Jian, Wong KK, Su L, Zhou D and Sharpless NE. Mitigation of hematologic radiation toxicity through pharmacological quiescence in mice. JCI 2010, 120: 2528-36. PMCID: PMC2898594.
18. Wang Y, Liu L, Pazhanisamy SP, Meng A, Zhou D. Total body irradiation selectively induces persistent oxidative stress in murine hematopoietic stem cells. Free Radic Biol and Med 2010; 48: 348-56. PMCID: PMC2818724.
19. Wang Y (corresponding author), Scheiber MN, Neumann C, Calin GA, Zhou D. MicroRNA Regulation of Ionizing Radiation-Induced Premature Senescence. Int J Radiat Oncol Biol Phys 2010 Nov 17. [Epub ahead of print] DOI: 10.1016/J.ijrobp.2010.09.048.
20. Pazhanisamy SK, Li H, Wang Y, Batinic-Haberle I, Zhou D. NADPH oxidase inhibition attenuates total body irradiation-induced hematopoietic genomic instability. Mutagenesis 2011, in press
21. Wang Y, Keller J, Liu L, Zhou D. Inhibition of p38 mitogen-activated protein kinase promotes ex vivo hematopoietic stem cell expansion. Stem Cells Dev 2011; [Epub ahead of print] DOI.i:10.1089/scd.2010.0413.