To serve patients, health care providers, research scientists, scholars, and society by providing excellence and innovation in diagnostic services and educational resources in a respectful, professional and culturally diverse atmosphere.
To become a preeminent leader in academic anatomic and clinical pathology while translating basic science discovery to improved clinical care.
Omar Moussa, M. Sc., Ph.D.
Director of HLA Laboratory
Department of Pathology & Laboratory Medicine
Office: Childrens Hospital Room 306
Phone: (843) 792-1794
B. Sc., 1986; Department of Chemistry, Mansoura University, Egypt
Master of Sc., 1991; Department of Biochemistry, Zagazip University, Egypt
Ph.D., 1999, Department of Biochemistry, Mansoura Univeristy, Egypt
Regulation of gene expression during cancer progression and metastasis
Molecular profiling of genitourinary malignancies.
Studying the role of Ets transcription factors in malignant transformation
Lab Scientist: December 1987- December 1999
Faculty: January 2000-January 2001; Urology and Nephrology Center, Mansoura University, Egypt.
Post-Doctoral Fellow: January 2001- December 2004; Department of Pathology, Medical University of South Carolina, Charleston
Assistant Professor: January 2005-present; Department of Pathology, Medical University of South Carolina, Charleston
Moussa, OM, H.G. Osman, M.A. El-Far, I. Eraki, and M. A. Ghoneim. Rapid diagnosis of genitourinary tuberculosis by polymerase chain reaction and non-radioactive DNA hybridization. J Urology, 164:584-588, 2000.
El-Sherbiny MT, Mousa OM, Shokeir AA, Ghoneim MA. Role of urinary transforming growth factor-beta1 concentration in the diagnosis of upper urinary tract obstruction in children. Journal of Urology 200;168:1798. 2002.
el-Agroudy AE, Refaie AF, Moussa OM, Ghoneim MA: Tuberculosis in Egyptian kidney transplant recipients: study of clinical course and outcome. J Nephrol. May-Jun;16(3):404-11. 2003.
Kubo, M., Czuwara-Ladykowska, J., Moussa, O M, Markiewicz, M., Smith. E., Silver, R. M., Jablonka, S. Blaszczyk, M., Watson, D. K., and Trojanowska, M.: Persistent downregulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin , Amer. J. Path., . Aug;163(2):571-81. 2003.
el-Agroudy AE, Hassan NA, Foda MA, Ismail AM, el-Sawy EA, Mousa O, Ghoneim MA: Effect of angiotensin II receptor blocker on plasma levels of TGF-beta 1 and interstitial fibrosis in hypertensive kidney transplant patients. Am J Nephrol. 2003 Sep-Oct;23(5):300-6.
Omar Moussa, Gabor Szalai, Hassan Abou-Elenin, Nabil K. Bissada, Mohamed A. Ghoneim, and Dennis K. Watson: Detection of Chromosomal Aberrations in Transitional Cell Carcinoma of the Bladder by Representational Difference Analysis: Cancer Genomics and Proteomics. 1: 9-16 (2004).
Zhang XK, Gallant S, Molano I, Moussa OM, Ruiz P, Spyropoulos DD, Watson DK, Gilkeson G. 2004. Decreased expression of the Ets family transcription factor Fli-1 markedly prolongs survival and significantly reduces renal disease in MRL/lpr mice. J Immunol 173:6481-6489.
Jackers P, Szalai G, Moussa O, Watson DK. Ets-dependent regulation of target gene expression during megakaryopoiesis. J Biol Chem 2004;279(50):52183-90.
Masuya M, Moussa O, Abe T, et al. Dysregulation of granulocyte, erythrocyte, and NK cell lineages in Fli-1 gene-targeted mice. Blood 2005;105(1):95-102.
Yordy, J.S., Moussa, O., Pei, H., Chaussabel, D., Li, R., and Watson, D.K., SP100 modulation of Ets1 regulated pathways in Endothelial cells, Oncogene 24: 916-931, 2005.
Moussa O., Yordy, J. S., Abou-Elenin H., Sinha, D., Bissada N. K., Halushka, P. V., Ghoneim MA, Watson, D. K.: Prognostic and Functional Significance of Thromboxane A2 synthase gene Overexpression in Invasive Bladder Cancer, Cancer Research 2005 15(65).24 (11581-11587).
Moussa, O., Abou-Enein, H., Bissada, N. K., Keane, T., Ghoneim, M. A., Watson, D.K.: Evaluation of survivin reverse transcriptase polymerase chain reaction (RT-PCR) for non-invasive detection of bladder cancer, J. Urology, 2006. 2006 Jun;175(6):2312-6.
Turner, D. P., Moussa, O., Sauane, M., Fisher, P. B., and Watson, D. K. Prostate-derived ETS factor is a mediator of metastatic potential through the inhibition of migration and invasion in breast cancer. Cancer Res, 67: 1618-1625, 2007.
Moussa, O., Riker, M.. Klein, J., Fraig, M., Halushka, P. V. and Watson, D. K.: Inhibition of Thromboxane Synthase Activity Modulates Bladder Cancer Cell Responses to Chemotherapeutic Agents, Oncogene 2008 Jan 3;27(1):55-62.
Turner, D.P., Findlay, V.J., Moussa, O., and Watson, D.K. 2007. Defining ETS transcription regulatory networks and their contribution to breast cancer progression. J Cell Biochem 102:549-559.
Moussa, O., Ashton, A., Fraig, M., Garrett-Mayer, E., Ghoneim, M. A., Halushka, P. V., and Watson, D. K.: Thromboxane (TP) beta receptors in human bladder cancer: Role in pathogenesis and prognosis in bladder cancer. Cancer Research 2008; 68: (11). June 1, 2008.
Zhang, X.K., Moussa, O., LaRue, A., Bradshaw, S., Molano, I., Spyropoulos, D.D., Ogawa, M., Gilkeson, G., Watson, D.K.: The Fli-1 Transcription Factor Modulates Marginal Zone B Cell and Follicular B Cell Development in Mice, J Immunology, 2008 Aug 1;181(3):1644-54..
Turner, D.P, and Watson, D.K. Differential expression of cytoskeleton associated genes mediated by PDEF regulates metastatic cell migration. Moleular Biology of Che Cell. 2008 Sep;19(9):3745-57. Epub 2008 Jun 25.
Findlay VJ, Moussa O, and Watson DK. miRNA-dependent modulation of PDEF protein expression in invasive breast cancer. Cancer Research 2008; Oct 15;68(20):8499-506.