Meenal Mehrotra, Ph.D.

Assistant Professor
Department of Pathology & Laboratory Medicine

Office: Strom Thurmond Research Building, Room 431
Office Phone: (843) 789-6712

Lab: Room # 434, Strom Thurmond Building
Lab Phone: 843-789-6712
Fax: (843) 876-5381

EDUCATION:

1992-1998 - M.B.B.S (MD), Medicine and Surgery, Gorakhpur University, Uttar Pradesh, India

1998-2002 - Ph.D., Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, India
               Dissertation title: Effect of Calcium Deprivation on Biochemical, Radiological and Molecular
               Indices of Calcium Homeostasis in Rabbit during Adulthood and Development

2002-2006 Postdoctoral Fellow, Endocrinology, University of Connecticut Health Center, Farmington, CT (Dr. Carol Pilbeam, Mentor)

2007- March 2010 Postdoctoral fellow, Pathology, Medical University of South Carolina, Charleston, SC (Drs. Makio Ogawa and Amanda LaRue, Mentors)

RESEARCH INTERESTS:

Tissue reconstituting potentials of hematopoietic stem cells (HSCs) focusing on bone development.

My primary research focus is on the role of Hematopoietic Stem Cell Transplantation a) as a possible therapy for Osteogenesis Imperfecta- a genetic disease of collagen disorder of the bone and b) in odontoblast differentiation and tooth development.

FUNDING:

NIH - 1K01AR059097-01
04/01/10 – 03/31/2013
Hematopoietic Stem Cell Transplantation in Osteogenesis Imperfecta $69,027
Role: PI

SELECTED PUBLICATIONS:

1. Mehrotra M, Williams CR, Ogawa M, and LaRue AC. Hematopoietic stem cells give rise to osteo-chondrogenic cells. Blood Cells, Molecules & Diseases, 50(1):41-49, 2013
2. Mehrotra M and LaRue AC. A therapeutic role for hematopoietic stem cells in osteogenesis imperfecta. Genetic Disorders, ISBN 980-953-307-751-7 (Invited book chapter).
3. Mehrotra M, Williams CR, Ogawa M, and LaRue AC. Hematopoietic stem cells give rise to osteo-chondrogenic cells. Blood Cells, Molecules & Diseases, 50(1):41-49, 2013
4. Mehrotra M and LaRue AC. A therapeutic role for hematopoietic stem cells in osteogenesis imperfecta. Genetic Disorders, ISBN 980-953-307-751-7 (Invited book chapter).
5. Mehrotra M, Rosol M, Ogawa M, Larue AC. Amelioration of a Mouse Model of Osteogenesis Imperfecta with Hematopoietic Stem Cell Transplantation: Micro-Computed Tomography Studies. Exp Hematol. 38(7):593-602, 2010.
6. Abangan RS, Williams CR, Mehrotra M, Duncan JD, LaRue AC. MCP1 Directs Trafficking of HSC-Derived Fibroblasts Precursors in Solid Tumor. Am J Pathol, 176:1914-26, 2010.
7. Shirai K, Sera Y, Bulkeley W, Mehrotra M, Moussa O, LaRue AC, Watson DK, Stuart RK, Lazarchick J, Ogawa M: Hematopoietic Stem Cell Origin of Human Fibroblasts: Cell Culture Studies of Female Recipients of Gender Mismatch Stem Cell Transplantation and Patients with Chronic Myelogenous Leukemia. Exp Hematol 37: 1464-1471, 2009.
8. Sera Y, LaRue AC, Moussa O, Mehrotra M, Duncan JD, Williams CR, Nishimoto E, Schulte BA, Watson PM, Watson DK, Ogawa M: Hematopoietic Stem Cell Origin of Adipocytes. Exp Hematol 37: 1108-1120, 2009.
9. Kaneko H, Mehrotra M, Alander C, Lerner U, Pilbeam C, Raisz L. Effects of prostaglandin E2 and lipopolysaccharide on osteoclastogenesis in RAW 264.7 Cells. Prostaglandins Leukot Essent Fatty Acids, 2007; 77:181-6. (The first two authors contributed equally to the study).
10. Xu Z, Choudhary S, Voznesensky O, Mehrotra M, Woodard M, Hansen M, Herschman H, Pilbeam C. Overexpression of cyclooxygenase-2 in human osteosarcoma cells decreases proliferation and increases apoptosis. Cancer Research, 2006; 66: 6657-64.
11. Mehrotra M, Saegusa M, Wadhwa S, Voznesensky O, Peterson D, Pilbeam C. Fluid shear stress regulation of RANKL expression in primary murine calvarial osteoblasts. Journal of Cellular Biochemistry, 2006; 98: 1271-1283.
12. Mehrotra M, Saegusa M, Voznesensky O, Pilbeam C. Role of Cbfa1/Runx2 in the fluid shear stress induction of COX-2 in osteoblasts. Biochem Biophys Res Commun, 2006; 341: 1225-1230.
13. Mehrotra M, Gupta SK, Kumar K, Awasthi PK, Dubey M, Pandey C, Godbole MM. Calcium deficiency induced secondary hyperparathyroidism and osteopenia is rapidly reversible with calcium supplementation. British Journal of Nutrition, 2006; 95: 582-590.
14. Mehrotra M, Krane SM, Walters K, Pilbeam C. Differential regulation of platelet-derived growth factor stimulated migration and proliferation in osteoblastic cells. Journal of Cellular Biochemistry, 2004; 93: 741-752.