Amanda C. LaRue, PhD

Assistant Professor, Department of Pathology & Laboratory Medicine
Office: Ralph H. Johnson VA Medical Center Research Services Room 151
Phone: (843) 789-6712
Fax: (843) 876-5381

EDUCATION:

1993-1997 B.S., Biology; B.A., French; Wofford College, Spartanburg, South Carolina
1999-2003 Ph.D., Molecular, Cellular and Pathobiology, Medical University of South Carolina, Charleston, South Carolina

RESEARCH INTERESTS:

My primary research focus is the tissue reconstituting potentials of hematopoietic stem cells (HSCs). Current studies in the laboratory are aimed at two major areas of interest: 1) the role of HSCs in the development and progression of solid tumors and 2) the role of HSCs in the generation of mesenchymal cells including osteocytes and chondrocytes.

SELECTED PUBLICATIONS:

1. Drake, C.J., LaRue, A., Ferrara, N., and Little, C.D. (2000). VEGF regulates cell behavior during vasculogenesis. Developmental Biology, 224, 18-188.
2. Argraves, W.S., LaRue, A.C., Fleming, P.A and Drake, C.J. (2002). VEGF is required for the assembly but not the maintenance of embryonic blood vessels. Developmental Dynamics, 225, 298-304.
3. LaRue, A.C., Mironov, V.A., Argraves, W.S., Czirók, A., Fleming, P.A and Drake, C.J. (2003). Patterning of embryonic blood vessels. Developmental Dynamics, 228, 21-29.
4. LaRue, A.C., Lansford, R., and Drake, C.J. (2003). Blood island-derived stem cells contribute to intraembryonic vasculogenesis. Developmental Biology, 262, 162-172.
5. Drake, C.J., Fleming, P.A., LaRue, A.C., Barth, J.L., Chintalapudi, M.R. and Argraves,
6. W.S. (2004). Differential distribution of Cubilin and Megalin expression in the mouse embryo. The Anatomical Record, Part A, 277A:163-170.
7. LaRue, A.C., Zile, M.H., and Drake, C.J. (2004). Normal vascular morphogenesis requires retinol-mediated regulation of endothelial cell numbers. Developmental Dynamics, 230(4), 666-674.
8. Wang, Y., Schulte, B.A., LaRue, A.C., Ogawa, M. and Zhou, D. (2005). Total body irradiation selectively induces murine hematopoietic stem cell senescence. Blood, 107, 358-366.
9. Ebihara, Y., Masuya, M., LaRue, A.C., Yang, S., Owens, R.W., Argraves, K., Visconti, R.P., Fleming, P.A., Minamiguchi, H., Hill, W.D. Martin-Studdard, A., Drake, C.J., Ogawa, M. (2006). Fibroblasts, CFU-F and fibrocytes are derived from bone marrow hematopoietic stem cells. Experimental Hematology, 34, 219-229.
10. LaRue, A.C., Masuya, M., Ebihara, Y., Fleming, P.A., Visconti, R.P., Ogawa, M., and Drake, C.J. (2006). The hematopoietic origin of tumor fibroblasts and pericytes. Experimental Hematology, 34, 208-218.
11. Visconti, R.P., LaRue, A.C., Ebihara, Y., McQuinn, T.C., Fleming, P.A., Minimaguchi, H., Markwald. R.R., Ogawa, M., Drake, C.J. (2006). Hematopoietic stem cell-derived valve interstitial cells contribute to adult valve homeostasis. Circulation Research, 98, 690-6.
12. Ogawa, M., LaRue, A.C., Drake, C.J. (2006). Hematopoietic Origin of Fibroblasts/Myofibroblasts: Its Patho-physiological Implications. Blood, 108, 2893-2896.
13. Szalai, G., LaRue, A.C. and Watson, D.K. (2006). Molecular Mechanisms of Megakaryopoiesis. Cellular and Molecular Life Sciences, 63, 2460-2476.
14. Ogawa, M. and LaRue, A.C. (2007). Origin of CFU-F. Experimental Hematology. In press.
15. Moussa O., LaRue A.C., Szalai1 G., Zhang X.K., Masuya M., Gong Y.Z., Spyropoulos D.D., Ogawa M., Gilkeson G., Watson D.K. Hematopoietic defects in mice lacking the carboxy-terminal regulatory domain of the Ets transcription factor Fli1. (In Revision, Blood).
16. Book Chapters
17. LaRue, A.C. and Ogawa, M. (2007). Hematopoietic Origin of Fibrocytes. In Fibrocytes: New Insights into Tissue Repair and Systemic Fibroses. Editor, Richard Bucala.