Weimin Fan, M.D., M.P.H.

Professor, Department of Pathology & Laboratory Medicine
Professor, Department of Medicine
Department of Pathology & Laboratory Medicine
Office: Walton Research Building Room 709
Phone: (843) 792-5108
Fax: (843) 792-0368

EDUCATION:

M.D., 1983, Zhejiang Medical University
M.P.H., 1986, Zhejiang Medical University

RESEARCH INTERESTS:

Research interests in my laboratory are involved in several areas in cancer therapy and nanotechnology: 1) Hormonal and genetic control of tumor growth and cell cycle regulation. 2) Experimental therapeutics and mechanism of drug-induced apoptosis. 3) Estrogen receptors mediate drug resistance and underlyingmechanisms; 5) The role of cancer stem cells in drug resistance; 4) Explore nanoparticle-based target biochemotherapy for HER2/neu+ Breast Tumors; 5)Screening and preclinical evaluation of antimicrobial nanoparticles.

FUNDING:

Work in the laboratory is supported in part by research grants from the National Cancer Institute and other research foundations.

SELECTED PUBLICATIONS:

1. Huang Y, Johnson KR, Norris JS and Fan W. Nuclear factor-kB/I-kB signaling pathway may contribute to the mediation of paclitaxel-induced apoptosis in solid tumor cells. Cancer Res. 60:4426-4432, 2000
2. Zeng S, Chen YZ, Johnson KR and Fan W. In Vitro evaluation of sequential-dependent combination between docetaxel and doxorubicin in human tumor cells. Clin. Cancer Res. 6:3766-3773, 2000
3. Huang Y and Fan W. IkB kinase activation is involved in the regulation of paclitaxel-induced apoptosis in solid tumor cells. Mol. Pharmacol. 61:105-113, 2002
4. Johnson KR and Fan W. Potentiation of paclitaxel cytotoxicity in the presence of 5-fluouracil, via altered expression of p53 and p21waf1/c1p1. Anticaner Res. 22:3197-3204, 2002
5. Huang Y. Fang Y. Dziadyk J. Norris JN. Fan W. The possible correlation of the activation of NF-kB/I-kB pathway with the susceptibility of tumor cells to paclitaxel-induced apoptosis. Oncol. Res. 13:113-120, 2002
6. Fontaine M and Fan, W. Islet transplantation as a cure for insulin-dependent diabetes: current improvements in preserving islet cell mass and function, HBPD Int. 2:181-190, 2003
7. Sui M, Dziadyk J, Zhu XM and Fan W. Cell cycle dependent antagonistic interactions between paclitaxel and g-radiation in combination therapy. Clin. Cancer Res. 10:4848-4857, 2004
8. Dziadyk J, Zhu XM, Sui M, and Fan W. Paclitaxel-induced apoptosis may occur without a prior G2/m phase arrest. Anticancer Res. 24:27-36, 2004
9. Fan W, Sui M and Huang Y. Glucocorticoids selectively inhibit paclitaxel-induced apoptosis: Mechanisms and its clinical impact. Curr. Med. Chem. 11:403-411, 2004
10. Huang Y, Fang Y, Wu J, Dziadyk J, Zhu XM, Sui M and Fan W. Regulation of vinca alkaloid-induced apoptosis by NF-kB/IkB pathway in human tumor cells. Mol. Cancer Therap. 3: 271-277, 2004
11. Yang J, Deng X. Deng L. Gu H and Fan W. and Cao Y. Telomerase activation by Epstein-Barr virus latent membrane protein 1 is associated with c-Myc expression in human nasopharyngeal epithelial cells. J. Exp. Clin. Cancer Res. 23:495-506, 2004
12. Zhu X, Sui M. Dziadyk J. and Fan W. In vitro and in vivo evaluation tetrandrine on the reversal of P-glycoprotein-mediated drug resistance to paclitaxel. Anticancer Res. 25:1953-1962, 2005
13. Sui M and Fan W. Combination of g-radiation antagonizes the cytotoxic effects of vincristine and vinblastine on both mitotic arrest and apoptosis. Int. J. Radiat. Oncol. Biol. Phys.1151-1158, 2005
14. Sui M, Chen F, Chen Z and Fan W. Glucocorticoids interfere the therapeutic efficacy of paclitaxel against human breast and ovarian xenograft tumors. Int. J. Cancer. 119-712-717, 2006
15. Sui M. Xoing X, Kraft A. and Fan W. Combination of gemcitabine antagonizes antitumor activity of paclitaxel through prevention of mitotic arrest and apoptosis. Cancer Biol. Ther., 119:712-717, 2006
16. Sui M, Huang Y, Park BH, Davidson NE and Fan W. Estrogen receptor alpha mediates breast cancer cells resistance to paclitaxel through Inhibition of apoptotic cell death. Cancer Res, 67: 5337-5344, 2007
17. Xiong, X, Sui, M, Fan, W and Kraft A. Cell-Cycle Dependent Antagonistic Interactions between Paclitaxel and Carboplatin in Combination Therapy. Cancer Biol. Ther., 6: 607-13, 2007
18. Wang L, Jiang Z, Sui M, Shen J, Xu C, Fan W. The potential biomarkers in predicting pathologic response of breast cancer to three different chemotherapy regimens: a case control study. BMC Cancer, 9:226-235. 2009
19. Liu L, Xu K, Wang H, Tan PK, Fan W, Venkatraman SS, Li L, Yang YY, Self-assembled cationic peptide nanoparticles as an efficient antimicrobial agent. Nature Nanotechnol. 4:457-463. 2009
20. Xu W, Xi B, Wu J, An H, Zhu J, Abassi Y, Feinstein AC, Geng B, Fan W, Wang X, and Xu X. Natural Product Derivative, Bis(4-fluorobenzyl)trisulfide Inhibits Tumor Cell Growth by Modification of β-tubulin at Cys 12 and Suppression of Microtubule Dynamics, Mole Cancer Therap, 8:3318-3330, 2009
21. Wang J, Sui M and Fan W. Nanoparticles for Tumor Targeted Therapies and Their Pharmacokinetics. Current Drug Metab. 11:129-141, 2010
22. Song H, Yang j, Lo S, Wang Y., Fan W, Tang W, Xue J and Wang S. Nonviral Magnetofection Using Self-assembled Ternary Complexes of Cationic Magnetic Particle, Plasmid DNA and Andosomolytic Tat Peptide, Biomaterials, 31:769-778, 2010
23. Wang H, Xu K, Liu L, Tan JP, Chen Y, Li Y, Fan W, Wei Z, Sheng J, Yang YY, Li L. The efficacy of self-assembled cationic antimicrobial peptide nanoparticles against Cryptococcus neoformans for the treatment of meningitis. Biomaterials. 31:2874-2881, 2010
24. Sui M, Jiang D, Hinsch C, Fan W. Fulvestrant (ICI 182,780) sensitizes breast cancer cells expressing estrogen receptor alpha to vinblastine and vinorelbine. Breast Cancer Res Treat. 121:335-345,2010
25. Lee AL, Wang Y, Pervaiz S, Fan W, Yang YY. Synergistic Anticancer Effects Achieved by Co-Delivery of TRAIL and Paclitaxel Using Cationic Polymeric Micelles. Macromol Biosci.11:296-307, 2011
26. Lee AL, Dhillon SH, Wang Y, Pervaiz S, Fan W and Yang YY. Synergistic anti-cancer effects via co-delivery of TNF-related apoptosis-inducing ligand (TRAIL/Apo2L) and doxorubicin using micellar nanoparticles. Mol Biosyst. 7(5):1512-1522, 2011
27. Qin AJ,Zhang Y, Han N, Mei J, Sun JZ, Fan W and Tang BZh, Preparation and self-assembly of amphiphilic polymer with aggregation-induced emission characteristics, Science China Chem. 55:772-778, 2012
28. Zou WB, Zheng, HL, He TC, Chang JJ, Fu, YX and Fan W.* Mesenchymal Stem Cells Mediated-Delivery of LIGHT Targets Tumors and Mobilizes Immune Cells for Tumor Control, Cancer Res.72:2980-2989, 2012
29. Chang J, Sui M and Fan W.* Estrogen Receptor alpha Attenuates Therapeutic Efficacy of Paclitaxel on Breast Xenograft Tumors, Breast Cancer Res Treat. 134:969-980, 2012
30. Sui M, Zhang H, Di X, Chang J, Shen Y and Fan W.* G2 Checkpoint Abrogator Abates the Antagonistic Interaction between Antimicrotubule Drugs and Radiation Therapy. Radiotherapy and Oncology, 104:243-248, 2012
31. Liu L, Huang Y, Riduan SN, Gao S, Yang Y, Fan W.* and Zhang Y.* Main-chain imidazolium oligomer material as a selective biomimetic antimicrobial agent. Biomaterials.33:8625-8631, 2012
32. Liu SQ, Yang C, Huang Y, Ding X, Li Y, Fan W, Hedrick JL, and Yang YY. Antimicrobial and Antifouling Hydrogels Formed In Situ from Polycarbonate and Poly(ethylene glycol) via Michael Addition., Adv Materials, 24:6484-6489, 2012
33. Huang Y; Wiradharma N, Xu, K, Ji ZK, Sheng Bi; Li L, Yang YY and Fan W. Cationic amphiphilic α-helical peptides against carbapenem-resistant Acinetobacter baumannii infection., Biomaterials, 33:8841-8847, 2012
34. Fukushima K, Tan JP, Korevaar PA, Yang YY, Pitera J, Nelson A, Maune H, Coady DJ, Frommer JE, Engler AC, Huang Y, Xu K, Ji Z, Qiao Y, Fan W, Li L, Wiradharma N, Meijer EW, Hedrick JL. Broad Spectrum Antimicrobial Supramolecular Assemblies with Distinctive Size and Shape. ACS Nano. 6:9191-9199, 2012
35. Chang J and Fan W. Endocrine Therapy Resistance: Current Status, Possible Mechanisms and Overcoming Strategies. Anticancer Agent Med Chem, 13:464-475, 2013
36. Li Y, Fukushima K, Coady DJ, Engler AC, Liu S, Huang Y, Cho JS, Guo Y, Miller LS, Tan JP, Ee PL, Fan W, Yang YY, Hedrick JL. Broad-Spectrum Antimicrobial and Biofilm-Disrupting Hydrogels: Stereocomplex-Driven Supramolecular Assemblies. Angew Chem Int Ed Engl. 52: 674-678, 2013
37. Chen C, Wang Y, Goh SSL, Yang J, Lam DH, Chouhury Y, Tay FC, DS, Tan WK, Purwanti YI, Fan W and Wang S. Inhibition of neuronal nitric oxide synthase activity promotes migration of human induced pluripotent stem cell-derived neural stem cells towards cancer cells. J. Neurochem. Feb 14, 2013 [Epub Ahead of Print]
38. Huang Y, Fu PF, Fan W. Novel Targeted Therapies to overcome Trastuzumab Resistance in HER2-Overexpressing Metastatic Breast Cancer. Current Drug Targets, March 25, 2013 [Epub Ahead of Print]
39. Jiang DH, Sui M, Zhong WY, Huang Y. and Fan W.: Different Administration Strategies with Paclitaxel Induce Distinct Phenotypes of Multidrug Resistance in Breast Cancer Cells. Cancer Letters, March 7, 2013 [Epub Ahead of Print]
40. Shahbazi M, Kwang TW,Purwanti YI, Fan W and Wang S. Inhibitory effects of neural stem cells derived from human embryonic stems on differention and function of monocyte-dendritic cells. J. Neurol Sciences, In Press, 2013
41. Zhu D, Lam DH, Purwanti Y, Goh S, Wu C, Zeng J, Fan W and Wang S. Systemic Delivery of Fusogenic Membrane Glycoprotein-Expressing Neural Stem Cells to Selectively Kill Tumor Cells, Mol Therapy, In Press
42. Han N, Shu, W. Zheng SS and Fan W. Polymer-Based Cancer Nanotheranostics: Retrospectives of Multi-Functionalities and Pharmacokinetics, Current Drug Metab, In Press, 2013