Welcome to the home page of the Laboratory for Stem Cell Injury,
directed by Dr. Daohong Zhou, a Professor in the Department of Pathology and
Laboratory Medicine at Medical University of South Carolina. The research interests
of the Laboratory include:
- To elucidate the cellular and molecular mechanisms by which ionizing radiation
(IR) and chemotherapy cause normal tissue damage and develop new mechanism-based
interventions to ameliorate IR and chemotherapy-induced normal tissue injury.
- To study the long-term effects of genotoxic stress/DNA damage induced
by IR and chemotherapy on hematopoietic stem cell (HSC) self-renewal, genomic
stability, and plasticity and the role of HSC injury in IR- and chemotherapy-induced
long-term bone marrow suppression, leukemogenesis, and premature ageing in
an animal model.
- To delineate the underlying mechanisms of leukemia and
tumor resistance to IR and chemotherapy by comparing the cellular responses
(apoptosis, senescence or others) of normal adult tissue stem cells and those
of leukemic and tumor stem cells to IR and chemotherapy for the development
of novel therapeutic strategies to selectively target leukemic and tumor
stem cells.
Left to right, front row: Melissa Morris,
Jianwei Wang, Aimin Yang
Left to right, back row: Justin Yang, Joshua Kellner , Sara Cain, Senthil Pazhanisamy,
Daohong Zhou, Yong Wang
“When someone is seeking, it happens quite easily
that he only sees the thing that he is seeking; that he is unable to
find anything, unable to absorb anything, because he is only thinking
of the thing he is seeking, because he has a goal, because he is obsessed
with his goal. Seeking means: to have a goal; but finding means: to be
free, to be receptive, to have no goal.”
From Siddhartha by Hermann
Hesse |