Publications (Selected from last 5 years):

Lauderback, CM, Drake, JL, Zhou, D, Hackett, JM, Castegna, A, Kanski, J, Tsoras, M, Varadarajan, S, and Butterfield, DA: Derivatives of xanthic acid are novel antioxidants: Application to synaptosomes. Free Radical Research, 37:355-365, 2003.

Meng, A, Wang, Y, Van Zant, G, Zhou, D: Ionizing Radiation and Busulfan Induce Premature Senescence in Murine Bone Marrow Hematopoietic Cells. Cancer Research, 63:5414-9, 2003.

Meng, A, Wang, Y, Brown, SA, Van Zant, G, Zhou, D: Ionizing Radiation and Busulfan Inhibit Murine Bone Marrow Cell Hematopoietic Function via Apoptosis Dependent and Independent Mechanisms. Experimental Hematology, 31:1348-1356, 2003.

Meng, A, Yu, T, Chen, G, Brown, SA, Thompson, JS, Zhou,D: Cellular Origin of IR-Induced NF-B Activation in vivo and Role of NF-B in Ionizing Radiation-Induced Lymphocyte Apoptosis. Int. J. Radiat. Biol., 79:849-861, 2003.

Brown SA, Konopa JL, Zhou D, Thompson JS: Expression of TNF-alpha by CD3 and F4/80 Positive Cells following Allogeneic Spleen Cell Transplantation. Bone Marrow Transplantation, 33(4):359-65, 2004.   

Meng A, Luberto C, Meier P, Bai A, Yang X, Hannun YA, Zhou D: Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells. Experimental Cell Research, 292(2): 385-92, 2004.

Bai A, Meier GP, Wang Y, Luberto C, Hannun YA, Zhou D: Prodrug modification increases D609 chemical stability and cytotoxicity against U937 leukemia cells. Journal of Pharmacology and Experimental Therapeutics, 309: 1051-9, 2004.

Wang Y, Meng A, Zhou D: Role of Phosphatidylinositol-3-Kinase in Oxidative Stress-Induced Premature Senescence in Human Diploid Fibroblasts. Experimental Cell Research, 289:188-196, 2004.

Wang Y, Meng A, Lang H, Brown SA, Konopa JL, Kindy MS., Schmiedt RA, Thompson JA, Zhou, D: Lack of the NF-kB p50 or p65 gene sensitizes mice to ionizing radiation by increasing intestinal epithelial damage. Cancer Research, 63: 8791-812, 2004.

Grdina DJ, Murley JS, Kataoka Y, Zhou D, Seed TM: Radioprotectors: current status and new directions. Radiat Res. 163:704-5, 2005.

Wang Y, Schulte BA, Larue AC, Ogawa M, Zhou D: Total body irradiation selectively induces murine hematopoietic stem cell senescence. Blood, 107:358-66, 2006.

Wang Y, Schulte BA, Zhou D: Hematopoietic Stem Cell Senescence and Long-Term Bone Marrow Injury. Cell Cycle, 5:35-38, 2006.

Kawamori T, Osta W, Johnson KR, Pettus BJ, Tanaka T, Wargovich MJ, Reddy BS, Obeid LM, Hannun YA, Zhou D: Sphingosine kinase 1 is up-regulated in colon carcinogenesis. FASEB J, 20:386-8, 2006

Lang H, Schulte BA, Zhou D, Smythe N, Spicer SS, Schmiedt RA:  Deficiency of the p50 subunit of nuclear-factor kB causes progressive age-related auditory nerve degeneration and increased susceptibility to noise-induced hearing loss.  J Neuroscience, 26:3541-3550, 2006.

Lang, H., Ebihara Y, Schmiedt RA, Minamiguchi H, Zhou D, Smythe N, Liu L, Ogawa M, Schulte BA: Contribution of bone marrow hematopoietic stem cells to adult mouse inner ear: Mesenchymal cells and fibrocytes. Journal of Comparative Neurology, 496:187-201, 2006.

Wang Y, Probin V, Zhou D: Cancer therapy-induced residual bone marrow injury-Mechanisms of induction and implication for therapy. Current Cancer Therapy Review, 2: 271-279, 2006.

Probin V, Wang Y, Bai A, Zhou D: Busulfan selectively induces cellular senescence via a p53-independent but ERK-p38 MAPK-dependent mechanism. J. Pharmacol. Exp. Ther.  319: 551-560, 2007.

Probin V, Wang Y, Zhou D: Busulfan-induced senescence is dependent upon ROS production upstream of the MAPK pathway. Free Radical Biology and Medicine, 42: 1858-1865, 2007.