Room 613 Walton Research Building

Phone: 843-792-4874

Education:

• M.D., 1990, Chongqing Medical University
• Ph.D., 2001, Peking Union Medical College
• Postdoctoral Fellow, 2002-2006 Medical University of South Carolina

Research Interests:

• Cancer therapy-induced normal tissue injury
• Hematopoietic stem cell biology
• Molecular Radiobiology

Selected Publications:

Probin V, Wang Y and Zhou D. Busulfan-induced senescence is dependent upon ROS production upstream of the MAPK pathway. Free Radical Biology and Medicine, 42: 1858-1865, 2007.

Wang Y, Schulte BA, Larue AC, Ogawa M and Zhou D. Total body irradiation selectively induces murine hematopoietic stem cell senescence. Blood, 107:358-66, 2006.

Probin V, Wang Y, Bai A, and Zhou D. Busulfan selectively induces cellular senescence but not apoptosis in WI38 fibroblasts via a p53-independent but Erk-p38 MAPK-dependent mechanism. J Pharmacol Exp Ther, 319(2): 551-60, 2006.

Wang Y, Schulte BA, Zhou D. Hematopoietic stem cell senescence and long-term bone marrow injury. Cell Cycle, 5:35-38, 2006.

Wang Y, Probin V and Zhou D. Cancer therapy-induced residual bone marrow injury- Mechanisms of induction and implication for therapy. Current Cancer Therapy Reviews, 2(3): 271-279, 2006.

Wang Y, Meng A, Lang H, Brown SA, Konopa JL, Kindy MS, Schmiedt RA, Thompson JA, Zhou D. Activation of Nuclear Factor kB in vivo Selectively Protects the Murine Small Intestine against Ionizing Radiation-Induced Damage. Cancer Research, 64: 6240-6, 2004.

Wang Y, Meng A, Zhou D. Inhibition of phosphatidylinostol 3-kinase uncouples H2O2-induced senescent phenotype and cell cycle arrest in normal human diploid fibroblasts. Exp Cell Res, 298:188-96, 2004.

Bai A, Meier GP, Wang Y, Luberto C, Hannun YA, Zhou D. Prodrug modification increases D609 chemical stability and cytotoxicity against U937 leukemia cells. J Pharmacol Exp Ther, 309: 1051-9, 2004.

Meng A, Wang Y, Van Zant G, Zhou D. Ionizing Radiation and Busulfan Induce Premature Senescence in Murine Bone Marrow Hematopoietic Cells. Cancer Research, 63:5414-9, 2003.

Meng A, Wang Y, Brown SA, Van Zant G, Zhou D. Ionizing Radiation and Busulfan Inhibit Murine Bone Marrow Cell Hematopoietic Function via Apoptosis Dependent and Independent Mechanisms. Exp Hematol, 31:1348-1356, 2003.

Meng A, Yu T, Chen G, Brown SA, Wang Y, Thompson JS, Zhou D. Cellular Origin of IR-Induced NF-kB Activation in vivo and Role of NF-kB in Ionizing Radiation-Induced Lymphocyte Apoptosis.  Int J Radiation Biol, 79:849-861, 2003.

Zhang B, Wang Y, Zheng GG, Ma XT, Li G, Wu KF. Clinical significance of IL-18 gene over-expression in AML. Leukemia Res, 26: 887-92, 2002.

Wang Y, Li G, Zheng GG, Song YH, Wu KF. Detection and sequencing analysis of IL-18 expression in J6-1 leukemic cells. Leukemia Res, 25: 273-274, 2001.

Wang Y, Zheng GG, Wu KF, Li G and Rao Q. Construction of macrophage colony-stimulating factor receptor DNA vaccine. Haematologica, 86: 1219-1220, 2001.