Picture of Dr. Moussa

Omar Moussa, M. Sc., Ph.D.

Research Assistant Professor
Pathology and Laboratory Medicine

Room 313, Hollings Cancer Center

Phone: 843-792-1794
Fax:

Click to send Dr. Dammai email
Send email to Dr. Moussa

Blue Line: Divider

Education/Training:

 

Blue Line: Divider

Research Interests:

  • Regulation of gene expression during cancer progression and metastasis

  • Molecular profiling of genitourinary malignancies.

  • Studying the role of Ets transcription factors in malignant transformation

Blue Line: Divider

Recent Publications:

  • Moussa, OM, H.G. Osman, M.A. El-Far, I. Eraki, and M. A. Ghoneim. Rapid diagnosis of genitourinary tuberculosis by polymerase chain reaction and non-radioactive DNA hybridization. J Urology, 164:584-588, 2000.

  • El-Sherbiny MT, Moussa OM, Shokeir AA, Ghoneim MA. Role of urinary transforming growth factor-beta1 concentration in the diagnosis of upper urinary tract obstruction in children. Journal of  Urology 200;168:1798, 2002.

  • el-Agroudy AE, Refaie AF, Moussa OM, Ghoneim MA: Tuberculosis in Egyptian kidney transplant recipients: study of clinical course and outcome. J Nephrol. 16:404-11, 2003.

  • Kubo, M., Czuwara-Ladykowska, J., Moussa, O M, Markiewicz, M.,  Smith. E., Silver, R. M., Jablonka, S. Blaszczyk, M., Watson, D. K., and Trojanowska, M.: Persistent downregulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin, Amer. J. Path.163:571-81, 2003.

  • el-Agroudy AE, Hassan NA, Foda MA, Ismail AM, el-Sawy EA, Mousa O, Ghoneim MA: Effect of angiotensin II receptor blocker on plasma levels of TGF-beta 1 and interstitial fibrosis in hypertensive kidney transplant patients. Am J Nephrol. 23:300-6, 2003.

  • Moussa O, Szalai G, Abou-Elenin H, Bissada NK, Ghoneim MA, and Watson DK: Detection of Chromosomal Aberrations in Transitional Cell Carcinoma of the Bladder by Representational Difference Analysis: Cancer Genomics and Proteomics. 1: 9-16, 2004.

  • Yordy JS, Moussa O, Pei H, Chaussabel D, Li R, Watson DK. SP100 inhibits ETS1 activity in primary endothelial cells. Oncogene 24:916-31, 2005.

  • Zhang XK, Gallant S, Molano I, Moussa OM, Ruiz P, Spyropoulos DD, Watson DK, Gilkeson G. Decreased expression of the Ets family transcription factor Fli-1 markedly prolongs survival and significantly reduces renal disease in MRL/lpr mice. J Immunol 173:6481-6489, 2004.

  • Jackers P, Szalai G, Moussa O, Watson DK. Ets-dependent regulation of target gene expression during megakaryopoiesis. J Biol Chem 279:52183-90, 2004.

  • Masuya M, Moussa O, Abe T, et al. Dysregulation of granulocyte, erythrocyte, and NK cell lineages in Fli-1 gene-targeted mice. Blood 105:95-102, 2005.

  • Yordy, J.S., Moussa, O., Pei, H., Chaussabel, D., Li, R., and Watson, D.K., SP100 modulation of Ets1 regulated pathways in endothelial cells, Oncogene 24: 916-931, 2005.

  • Moussa O., Yordy, J. S., Abou-Elenin H., Sinha, D., Bissada N. K., Halushka, P. V., Ghoneim MA, Watson, D. K.: Prognostic and Functional Significance of Thromboxane A2 synthase gene Overexpression in Invasive Bladder Cancer, Cancer Research 15:11581-11587, 2005.

  • Moussa, O., Abou-Enein, H., Bissada, N. K., Keane, T., Ghoneim, M. A., Watson, D.K.: Evaluation of survivin reverse transcriptase polymerase chain reaction (RT-PCR) for non-invasive detection of bladder cancer, J. Urology, June; 175 (6) 2312-6.

  • Mao, L., Moussa, O., Yordy, J.S., Watson, D. K., and Zheng, W. J. MDframe: a computational framework for the high-throughput identification of human regulatory motifs. (Submitted for Publication).

  • Omar Moussa, Amanda C. LaRue, Gabor Szalai,  Xian K. Zhang, Masahiro Masuya, Yong Z. Gong, Demetri D Spyropoulos, Makio Ogawa, Gary Gilkeson, and Dennis K Watson: Hematopoietic defects in mice lacking the carboxy-terminal regulatory domain of the Ets transcription factor Fli1. (Submitted for publication)

  • Moussa, O., Feldman, R., Szalai, G., Sementchenko, V.I. and Watson, D.K.: PDEF expression is reduced in colon cancer and re-expression suppresses the growth of human colon cancer cells. In preparation

  • Turner D.P., Moussa O., Szalai G., Fisher P.B. and Watson D.K.: pdef is a mediator of metastatic potential through the inhibition of migration and invasion. In preparation

  • Moussa O, Abou-Elenin H, Bissada NK, Ghoneim MA, Watson D. K.: Clusterin is proapoptotic gene and its down-regulation is an early event in bladder cell carcinogenesis. In preparation

  • Moussa O, Fahmy WE, Semenchenko VI, Bissada NK, Watson DK. Inhibition of Ets2 function enhances the chemotherapeutic response of the androgen independent prostate cancer cell line DU145.  In preparation

  • Moussa O., Fahmy WE, Semenchenko VI, Bissada N.K., Watson D.K.: Ets2 target genes in prostate cancer cells. In preparation

  • Moussa, O., Kearny, P.L., Fraig, M., Halushka, P.V., and Watson, D.K.: In Vivo evaluation of thromboxane A2 receptor antagonist GR32191 in bladder cancer mouse model. In preparation

  • Moussa O, , Spyropoulos DD, Watson DK Immortalization of embryonic fibroblasts in Fli1 transcription factor  knockout mouse: A novel role of Fli1 in regulating cellular senescence and transformation. In preparation

  • Moussa, O.., Fraig, M., Halushka, P.V., and Watson, D.K.: Immunohistochemical analysis of Thromboxane synthase expression in human bladder cancer. In preparation

  • Moussa O., Keane T, Watson, D. K.: Molecular profiling of bladder cancer: correlation with disease parameters and patients outcome. In preparation

Blue Line: Divider

Return to the Faculty Listing Return to Faculty List