Hollings
Cancer Center Office: (843) 792-2443 |
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Fax: (843) 792-0368
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RESEARCH INTERESTS:
Epithelial-to-mesenchymal transition (EMT) was originally defined as an important developmental event involved in programmed morphogenesis during embryonic development. Recently, EMT has emerged as a critical event in initiating metastatic progression: progressive carcinomas undergo EMT, which includes cell dissociation, migration, extracellular matrix remodeling and cell invasion, resulting in a metastatic phenotype. My research interest is to study the role of epithelial-to-mesenchymal transition (EMT) in tumor invasion and metastasis. Specifically, we are focusing on ETS1, an Ets transcription factor, which modulates the EMT processes through its regulation of the transcriptional control of EMT-related genes. The current project is to elucidate how ETS1 function is modulated by EAPII, a negative modulator of ETS1, and to identify the role of EAPII in a potential signaling pathway that medicates extracellular signaling to ETS1 transcriptional activity.
FUNDING:
