Tien Hsu , Ph.D.
Professor
Pathology and Laboratory Medicine

National Institutes of Health (RO1GM57843, Principal Investigator) "Control of epithelial morphogenesis in Drosophila ovary," July 1, 2003-June 30, 2007.

National Cancer Institute (RO1CA109860, Principal Investigator) "VHL and FGFR signaling in angiogenesis," July 1, 2004-June 30, 2009.

National Cancer Institute (Project 2 Leader and Project 1 and Core C Co-Project Leader, PO1CA78582) "Role of Ets genes in transformation and differentiation," May 1, 2005-April 30, 2010. (PI: D. Watson, MUSC).

Hollings Cancer Center Xenograft Core Facility, Sept. 1, 2005-Aug. 31, 2007

EDUCATION:

REPRESENTATIVE RECENT PUBLICATIONS:

Hsu, T. (corresponding author), McRackan, D, Vincent, T.S. and de Couet, H.G. (2001) The Drosophila Pin1 prolyl isomerase Dodo is a MAP kinase signal responder during oogenesis. Nature Cell Biology 3: 538-543. (Accompanied by News and Views. Nature Cell Biology 3: E136-E137.) [Abstract] [Request for PDF]

Bagni, C., Bray, S., Gogos, J.A., Kafatos, F.C. and Hsu, T. (2002) The Drosophila zinc finger transcription factor CF2 is a myogenic marker downstream of MEF2 during muscle development. Mechanisms of Development 117: 265-268. [Abstract] [Request for PDF]

Dammai, V. and Hsu, T. (2003) EGF-dependent and independent activation of MAP kinase during Drosophila oogenesis. Anatomical Record 272A: 377-382. [Abstract] [Request for PDF]

Lavenburg, K.R., Ivey, J., Hsu. T. (co-corresponding author) and Muise-Helmericks, R. (2003) Coordinated functions of Akt and Ets1 in tubulogenesis. FASEB J. 17: 2278-2280 [Selected for cover photo]. [Abstract] [Full Text]

Dammai, V., Adryan, B., Lavenburg, K.R. and Hsu, T. (2003) Drosophila awd, the homolog of human nm23, regulates FGF receptor levels and functions synergistically with shi/dynamin during tracheal development. Genes & Dev. 17: 2812-2824. [Abstract] [Full Text]

Hsu, T., Trojanowska, M. and Watson, D.K. (2004) Ets proteins in biological control and cancer. J. Cell. Biochem.  91: 896-903. (Review) [Abstract] [Request for PDF]

Hsouna, A., Watson,  D.K. and Hsu, T. (2004) Developmental expression patterns of D-ets4, the Drosophila homologue of human Pdef. Gene Expr. Patterns 5: 285-289. [Abstract] [Full Text]

Cavaliere, V., Donati, A., Hsouna, A., Hsu, T. and Gargiulo, G. (2005) The dAkt kinase controls follicle cell size during Drosophila oogenesis. Developmental Dynamics 232: 845-854. [Abstract] [Full Text]

Adereth, Y., Champion, K. J., Hsu, T. and Vincent Dammai (2005) Site-directed mutagenesis using Pfu-DNA polymerase and T4-DNA ligase. BioTechniques 38: 864, 866, 868. [Request for PDF]

Pei, H., Li, C., Adereth, Y., Hsu, T., Watson, D.K. and Li, R. (2005) Caspase-1 is a direct target gene of ETS1 and plays a role in ETS1-induced apoptosis. Cancer Research 65: 7205-7213. [Abstract] [Full Text]

Adereth, Y., Dammai, V., Kose, N., Li, R. and Hsu, T. (2005) RNA-dependent integrin 3 protein localisation regulated by the Muscleblind-like protein MLP1, Nature Cell Biology  7: 1240-1247 [Accompanied by News and Views Nature Cell Biology 7: 1155-1156] Abstract ] [Request for PDF ]

Arquirer, N., Vigne, P., Dupla, E., Hsu, T., Therond, P.P., Frelin, C. and D'Angelo, G. (2005) The tissue specificity of hypoxic signaliling in Drosophila melanogaster is dependent on VHL expression. Biochem. J., [E-publication ahead, Sept. 2005]. [Abstract] [Full Text]

Hsu, T. (co-corresponding author), Adereth, Y.†, Kose, N. and Dammai, V. (2006) Endocytic function of Von Hippel-Lindau tumor suppressor protein regulates surface localization of FGF receptor 1 and cell motility.  J. Biol. Chem.281: 12069-12080. [Abstract] [Full Text]
           
Hsouna, A., Lawal, H.O., Izevbaye, I., Hsu, T. (co-corresponding author) and O'Donnell, J.M. (2007) Drosophila dopamine synthesis pathway genes regulate tracheal morphogenesis. Dev. Biol. 308: 30-43. [Abstract] [Full Text]

Chintalapudi, M. R., Markiewicz, M., Kose, N, Dammai, V., Championl, K.J., Hoda, R. S., Trojanowska, M. and Hsu, T. Cyr61/CCN1 and CTGF/CCN2 mediate the pro-angiogenic activity of VHL mutant renal carcinoma cells. Submitted to Carcinogenesis, in press.

Nallamothu, G., Woolworth, J.A., Dammai, V. and Hsu, T. awd, the homolog of metastasis suppressor gene Nm23, regulates Drosophila epithelial cell invasion. Submitted to Mol. Cell. Biol, in revision.

Champion, K.J., Guinea, M., Dammai, V. and Hsu, T. Endothelial function of von Hippel-Lindau tumor suppressor gene: control of FGF receptor signaling. Submitted to Cancer Research, in revision.

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