Professor
of Pathology and Laboratory Medicine
Professor of Medicine
Room 704 Walton Research Building
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Phone: 843-792-5108 |
Fax: 843-792-0368 |
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Education:
Research Interests: Current research in our laboratory is involved in several areas of molecular oncology: 1) Hormonal and genetic control of tumor growth and cell cycle regulation. This study is currently focused on characterization of a newly identified transcriptional repressor, TA16, and analyzing its molecular mechanism in the mediation of glucocorticoid-induced cell cycle arrest and growth suppression in steroid-sensitive leiomyosarcoma and prostate cancer cells. 2) Experimental therapeutics and mechanism of drug-induced apoptosis. This project is to investigate the molecular basis of apoptotic cell death induced by paclitaxel and other antimicrotubule agents. Specifically, our current study is centered on elucidating the regulatory role of the NF-kB signaling pathway in the mediation of drug-induced apoptosis. In addition, this laboratory is also interested in screening and characterization of naturally occurring MDR modulators that can specifically inhibit P-pg-mediated multidrug resistance.
Funding: Work in
the laboratory is supported in part by research grants from the National
Cancer Institute.
Selected Publications:
Fan W, Ma JX, Cheng L and Norris JS. Molecular cloning of TA16, a transcription repressor, that may mediate glucocorticoid-induced growth arrest of leiomyosarcoma cells, Mol. Endocrinol. 11:1342-1352, 1997 [Abstract] [Full Text]
Johnson KR, Young KK, and Fan W. Antagonistic interplay between anti-mitotic and G1/S arresting agents in experimental combination therapy. Clin. Cancer Res. 5:2559-2565, 1999 [Abstract] [Full Text]
Fan W. Possible mechanisms of paclitaxel-induced apoptosis. Biochem. Pharmacol. 57:1215-1221, 1999 [Abstract] [Full Text]
Huang Y, Johnson KR, Norris JS and Fan W. Nuclear factor-kB/I-kB signaling pathway may contribute to the mediation of paclitaxel-induced apoptosis in solid tumor cells. Cancer Res. 60:4426-4432, 2000 [Abstract] [Full Text]
Zeng S, Chen YZ, Johnson KR and Fan W. In Vitro evaluation of sequential-dependent combination between docetaxel and doxorubicin in human tumor cells. Clin. Cancer Res. 6:3766-3773, 2000 [Abstract] [Full Text]
Huang Y and Fan W. IkB kinase activation is involved in the regulation of paclitaxel-induced apoptosis in solid tumor cells. Mol. Pharmacol. 61:105-113, 2002 [Abstract] [Full Text]
Sui M, Dziadyk J, Zhu XM and Fan W. Cell cycle dependent antagonistic interactions between paclitaxel and g-radiation in combination therapy. Clin. Cancer Res. 10:4848-4857, 2004 [Abstract] [Full Text]
Fan W, Sui M and Huang Y. Glucocorticoids selectively inhibit paclitaxel-induced apoptosis: Mechanisms and its clinical impact. Curr. Med. Chem. 11:403-411, 2004 [Abstract] [Full Text]
Huang Y, Fang Y, Wu J, Dziadyk J, Zhu XM, Sui M and Fan W. Regulation of vinca alkaloid-induced apoptosis by NF-kB/IkB pathway in human tumor cells. Cancer Mol. Therap. 3: 271-277, 2004 [Abstract] [Full Text]
Sui M and Fan W. Combination of g-radiation antagonizes the cytotoxic effects of vincristine and vinblastine on both mitotic arrest and apoptosis. Int. J. Radiat. Oncol. Biol. Phys.1151-1158, 2005 [Abstract] [Full Text]
Sui M, Chen F, Chen Z and Fan W. Glucocorticoids interfere the therapeutic efficacy of paclitaxel against human breast and ovarian xenograft tumors. Int. J. Cancer. 119-712-717, 2006 [Abstract] [Full Text]
Sui M, Xoing X, Kraft A and Fan W. Combination of gemcitabine antagonizes antitumor activity of paclitaxel through prevention of mitotic arrest and apoptosis. Cancer Biol. Ther. 5:1015-1021, 2006 [Abstract] [Full Text]
