Vincent Dammai, M. Phil., Ph.D.

Assistant Professor
Pathology and Laboratory Medicine

Office: Rm 316, Hollings Cancer Center
Lab: Rm. 341, Hollings Cancer Center

Office Phone: 843-792-7568
Lab Phone: 843-792-7598
Fax: 843-792-5002

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Education:

• M.S: 1992, University of Hyderabad, Hyderabad, India.
• M.Phil: 1995, Jawaharlal Nehru University, New Delhi, India.
• PhD: 1999, Jawaharlal Nehru University, New Delhi, India
• Post-Doctoral Fellowship: 1999-2001, University of California San Diego.

Employment:

• Research Associate: 2001-2004, Medical University of South Carolina.
• Research Assistant Professor: 2004-2007, Medical University of South Carolina
• Assistant Professor: 2007- Present, Medical University of South Carolina.

•  Cell adhesion, intracellular protein trafficking and tumor metastasis

Funding:

• RO1 (NIH/NCI)
• Completed: DOD Phase VII (Geocenters)

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Publications:

• Nallamothu G., Woolworth J.A., Dammai V. (co-corresponding author), Hsu T. (2008).  awd,  the homolog of metastasis suppressor gene Nm23, regulates Drosophila epithelial cell invasion. Molecular and Cellular Biology  28(6):1964-1973.

• Mahajan S., Dammai V., Hsu T., Kraft A.S. (2008). Hypoxia-inducible Factor-2a Regulates The Expression of TRAIL Receptor DR5 in Renal Cancer Cells. Carcinogenesis.

• Champion K.J., Guinea M., Dammai V., and Hsu T. (2008). Endothelial function of von-Hippel Lindau tumor suppressor gene: control of FGF receptor signaling. Cancer Research. (in press)

• Chintalapudi M.R., Markiewicz M., Kose N., Dammai V., Champion K.J., Hoda R.S., Trojanowska M., Hsu T (2008). Cyr61/CCN1 and CTGF/CCN2 mediate the pro-angiogenic activity of VHL mutant renal carcinoma cells. Carcinogenesis 29(4):696-703

• Dammai V (2008). Endosomal Compartments. Encyclopedia of Cancer (2nd edition). Manfred Schwab (editor). Springer. (in press)

• Dammai V (2008). A rapid and versatile PCR-based site-directed mutagenesis protocol for generation of mutations along the entire length of a cloned cDNA. In vitro Mutagenesis Protocols. Humana Press. (Book chapter)

• Hsu T., Adereth Y., Kose N., Dammai V. (2006).  Endocytic function of Von Hippel-Lindau tumor suppressor protein regulates surface localization of FGF receptor 1 and cell motility. Journal of Biological Chemistry 281(17):12069-12080.

• Adereth Y., Dammai V., Kose N., Li R., Hsu T. (2005).  RNA-dependent integrin a3 protein localisation regulated by the zinc-finger protein MLP1/MBLL/MBNL2. Nature Cell Biology. 7(12):1240-1247.

• Kumar R., Dammai V., Yadava P.K., Kleinau S. (2005).  Gene targeting by ribozyme against TNF-alpha mRNA inhibits autoimmune arthritis. Gene Therapy 12(20): 1486-1493.

• Adereth Y., Champion K.J., Hsu.T., Dammai .V  (2005).  Site-directed mutagenesis using Pfu-DNA polymerase and T4-DNA ligase. Biotechniques 38(6):864-868.

• Dammai V., Adryan B., Lavenburgh K.R., Hsu T. (2003).  Drosophila awd, the homolog of human nm23, regulates FGF receptor levels and functions synergistically with shi/dynaminduring tracheal development. Genes and Development 17 (22): 2812-2824.

• Dammai V., Hsu T. (2003).  EGF-dependent and independent activation of MAP kinase during Drosophila oogenesis. Anatomical Record. (Part A) 272A:377–382.

• Yadava R., Dammai V., Kumar R.,Yadava PK  (2003).   Application of ribozymes in therapy and developing disease model. In: Trends in Animal Biotechnology (ed..Srivastava, A.K.), Ch. 3, pp 42-59, Oxford University Press.

• Subramani S., Dammai V., Hazra, P., Suriapranata I.. and Lee S.  (2002).  Import of proteins into peroxisomes. In Protein targeting, transport and translocation, (eds. Dalbey, R.E. and von Heijne, G.), Ch. 12, pp. 268-292, Academic Press.

• Dammai V, Subramani S. (2001).  The human peroxisomal targeting signal receptor, Pex5p, is translocated into the peroxisomal matrix and recycled to the cytosol. Cell. 105(2):187-196.

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