709-B Walton Research Building

Phone: 843-792-5320

Education:

Research Interests:

My research interests are focused on cancer biology and experimental therapeutics. My current work includes several related areas:  (1) Evaluating combination therapy with multiple drugs or modalities; (2) Investigating the influence of steroid hormones/hormone receptors on susceptibility to anticancer treatments; (3) Elucidating the molecular mechanisms or signaling pathways that mediate drug-induced apoptosis; (4) Screening and preclinical evaluation of new drugs targeting cancer and inflammation.

Funding:Supported in part by research grants from the National Cancer Institute and Pharmaceutical Companies.

Selected Publications:

Sui MH and Li JC. The Discovery of Ovary Lymphatic Stomata in Human and its Significance. Acta Anat Sinica 32(3): 220-222, 2001

Sui MH and Li JC. The Presence of the Lymphatic Stomata in Ovarian Bursa of Guinea Pig and the Ultrastructure of Ovarian Bursa.  Shi Yan Sheng Wu Xue Bao 34(3): 291-297, 2001 [Abstract]

Sui MH and Li JC. The Development of the Ovarian Bursa and the Lymphatic Stomata in Golden Hamster. Prog Anat Sci 7(4): 355-357, 2001

Sui MH and Li JC. The Influence of Pregnancy and Hormone on the Lymphatic Stomata in Guinea Pig’s Ovarian Bursa.  Shi Yan Sheng Wu Xue Bao 36(1): 43-48, 2003 [Abstract]

Dziadyk J, Sui M, Zhu X and Fan W. Paclitaxel-induced Apoptosis May Occur without a Prior G2/M Phase Arrest. Anticancer Res 24: 27-36, 2004 [Abstract]

Sui M, Dziadyk J, Zhu X and Fan W. Cell Cycle-dependent Antagonistic Interactions between Paclitaxel and Gamma-radiation in Combination Therapy. Clin Cancer Res 10:4848-4857, 2004 [Abstract]

Fan W, Sui M and Huang Y. Glucocorticoids Selectively Inhibit Paclitaxel-induced Apoptosis: Mechanisms and Its Clinical Impact. Curr Med Chem 11:403-411, 2004 [Abstract]

Huang Y, Fang Y, Wu J, Dziadyk J, Zhu X, Sui M and Fan W. Regulation of Vinca Alkaloid-induced Apoptosis by NF-kappaB/IkappaB Pathway in Human Tumor Cells. Mol Cancer Therap 3: 271-277, 2004 [Abstract]

Sui M and Fan W. Combination of Gamma-radiation Attenuates the Cytotoxic Effects of Vincristine and Vinblastine on both Mitotic Arrest and Apoptosis. Int J Radiat Oncol Biol Phys 61:1151-1158, 2005 [Abstract]

*Zhu X, *Sui M and Fan W. In Vitro and In Vivo Characterizations of Tetrandrine on the Reversal of P-glycoprotein-mediated Multidrug Resistance to Paclitaxel. Anticancer Res 25:1953-1962, 2005 (*Equal Contribution) [Abstract]

Sui M, Chen F, Chen Z and Fan W.  Glucocorticoids Interfere with the Therapeutic Efficacy of Paclitaxel against Human Breast and Ovarian Xenograft Tumors. Int J Cancer, 119:712-717, 2006 [Abstract]

Sui M, Xiong X, Kraft A and Fan W. Combination of Gemcitabine Antagonizes Antitumor Activity of Paclitaxel through Prevention of Mitotic Arrest and Apoptosis.  Cancer Biol & Ther, 5 (8): 1015-1021, 2006 [Abstract]

Sui M, Huang Y, Park BH, Davidson NE and Fan W. Estrogen Receptor alpha Mediates Breast Cancer Cells Resistance to Paclitaxel through Inhibition of Apoptotic Cell Death. Cancer Res, 67(11): 5337-5344, 2007 [Abstract]

Xiong X, Sui M, Fan W and Kraft A. Cell-Cycle Dependent Antagonistic Interactions between Paclitaxel and Carboplatin in Combination Therapy. Cancer Biol & Ther, 6(7), E-pub ahead of print, 2007 [Abstract]