Phone: 843-792-3574

Clinical Expertise:

• Cytogenetics

• Molecular Pathology

• Fluorescence In situ hybridization (FISH)

Education:

• B.A., 1985, College of Notre Dame of Maryland, Baltimore

• Ph.D., 1991, Division of Human Genetics, University of Maryland at Baltimore

• Post-doctoral Fellowship, 1992, Department of Genetics, Stanford University

• 1993-1995, Clinical Cytogenetics and Clinical Molecular Genetics Fellow, Center for Human Genetics, Cleveland, Ohio

Research Interests:

1. X Inactivation

2. Molecular Cytogenetics

3. Genetics of Autism

Recent Publications:

1. Wolff DJ, Clifton K, Karr C, Charles J. A Pilot assessment of the subtelomeric regions of children with autism: Detection of a 2q deletion. Genet Med 4:10 – 14, 2002.

2. Nichols DW, Wolff DJ, Self S, Metcalf JS, Jacobs D, Kneuper-Hall R, Cate JC. Development of a testing algorithm for determination of HER2 status in patients with breast cancer. Annals Clin Lab Sci, 32:3 – 11, 2002

3. Collins JS, Olson RL, DuPont BR, Wolff DJ, Best RG, Stevenson RE. Prevalence of aneuploidies in South Carolina in the 1990s. Genet Med 4:131 – 135, 2002

4. Johnson WH Jr, Yang P, Yang T, Lau YR, Mostella BA, Wolff DJ, Roden DM, Woodrow Benson D. Clinical, genetic and biophysical characteristics of a homozygous HERG mutation causing severe neonatal long QT syndrome. Pediatr Res 2003; 53(5):744-8

5. Sebastian S, Spitzer SG, Grosso LE, Amos J, Schaefer FV, Lyon E, Wolff DJ, Hajianpour A, Taylor AK, Millson A, Stenzel TT. Multicenter Characterization and Validation of the Intron-8 Poly(T) Tract (IVS8-T) Status in 25 Coriell Cell Repository Cystic Fibrosis Reference Cell Lines for Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Gene Mutation Assays. Clin. Chem., Jan 2004; 50: 251 - 254.

6. Cady FM, Muto DN, Ciabeterri G, Johns A, Church KG, Wolff DJ. Utility of FISH probe panels for interphase studies of chronic lymphocytic leukemia and multiple myeloma for routine clinical cytogenetics evaluations. J Assoc Genet Tech, 3:77-81, 2004.

7. Christiansen LR, Lage JM, Wolff DJ, Pai GS, Harley RA. Mosaic duplication 1(q11q44) in an infant with nephroblastomatosis and mineralization of extraplacental membranes. Pediatr Dev Pathol. 8:115-23, 2005

8. Christiansen L, Allen RA, Dunn T, Wolff DJ. A case of infantile AML with MLL-MLL10 fusion caused by insertion of 11q into 10p. Canc Genet Cytogenet, in press.

9. Quigley DI, Wolff DJ. Cytogenetics Case Load and FTE Survey Summary 2005. J Assoc Genet Tech, in press.

10. Laudadio, J, Keane TE, Reeves HM, Savage SJ, Hoda RS, Lage JM, Wolff DJ. Fluorescence in situ hybridization for the detection of transitional cell carcinoma: Implications for clinical practice. Br J Urol, in press.