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Yuko Y. Palesch, Ph.D.
Professor, Clinical Innovation Group
Phone: (843) 876-1917
Fax: (843) 876-1932
Email: paleschy@musc.edu
Education:
Cornell University B.A. 1976 Biology
University of Pittsburgh M.S.Hyg. 1977 Biostatistics
George Washington University Ph.D. 1990 Statistics
Research Interests:
Dr. Palesch's research focus and interest are issues pertinent to clinicial trials implementation and analyses, and in particular, innovative study designs and randomization schemes; handling of missing data and analysis with missing data; and methods for simultaneous evaluation of multiple outcomes.
Selected Recent Publications:
Palesch YY, Lachin JM. Asymptotically distribution-free multivariate rank tests for multiple samples with partially incomplete observations. Statistica Sinica 1994; 4:373-87.
Walle T, Walle K, Mathur RS, Palesch YY, Conradi EC. Propanolol metabolism in normal subjects - association with sex steroid hormones . Clinical Pharmacology and Therapeutics 1994; 56:127-32.
Godenick MT , Musham C, Palesch YY, Hainer BL, Michels PJ. The physical and psychological health of family practice residents: a South Carolina Family Practice Research Consortium Study. Family Medicine 1995; 27:646-51.
Pinosky ML, Fishman RL, Reeves ST , Harvey SC, Patel S, Palesch YY, Dorman BH. The effect of bupivacaine skull block on the hemodynamic response craniotomy. Anesthesia and Analgesia 1996; 83:1256-61.
Maricq HR, Weinrich MC, Valter I, Palesch YY, Maricq JG. Digital vascular responses to cooling in subjects with cold sensitivity, primary Raynaud’s phenomenon, or scleroderma spectrum disorders . Journal of Rheumatology 23:2068-2078, 1996.
Akazawa K, Nakamura T, Palesch YY. Power of logrank test and cox regression model in clinical trials with heterogeneous samples. Statistics in Medicine 1997; 16:583-97.
Maricq HR, Carpentier PH, Weinrich, MC, Keil JC, Palesch YY, Biro C, Vionnet-Fuasset M, Jiguet M. Geographic variation in the prevalence of Raynaud’s phenomenon: a five-region comparison. Journal of Rheumatology 1997; 24:879-89.
Tarnasky PR, Cunningham, JT, Cotton PB, Hoffman BJ, Palesch YY, Freeman J, Curry NS , Hawes RH. Pancreatic sphincter hypertension increases the risk of post-ERCP pancreatitis. Endoscopy 1997; 29:252-7.
Johnson KE, Sanders JJ, Gellin RG, Palesch YY. The effectiveness of a magnetized water oral irrigator (HydroFloss ®) on plaque, calculus and gingival health. Journal of Clinical Periodontology 1998; 25:316-21.
Palesch YY, Dunbar JD, Lackland DT. Assessment of establishing a birth defects registry. Journal of Registry Management 1998; 25:67-71.
Gore EA, Sanders JJ, Pandey JP, Palesch YY, Galbraith GMP. Interleukin-1 $ +3953 allele 2: association with disease status in adult periodontitis. Journal of Clinical Periodontology 1998; 25:781-5.
Tarnasky PR, Palesch YY, Cunningham JT, Cotton PT, Hawes RH. Pancreatic stenting prevents pancreatitis after biliary sphincterotomy in patients with pancreatic sphincter of Oddi dysfunction. Gastroenterology 1998; 115:1518-24.
Hainer B, Palesch YY. Depressive symptoms in family practice residents: a South Carolina Family Practice Research Consortium Study. Academic Medicine 1998; 73:1305-10.
Galbraith GMP, Palesch YY, Gore EA, Pandey JP. Contribution of Interleukin 1 $ and KM loci to alopecia areata. Human Heredity 1999; 49:85-9.
Palesch YY, Maricq HR, Carpentier PH, Valter I. Association of cigarette and alcohol consumption with Raynaud's phenomenon .Journal of Clinical Epidemiology 1999; 52: 321-8.
Galbraith GMP, Hendley TM, Sanders JJ, Palesch YY, Pandey JP. Polymorphic cytokine genotypes as markers of disease severity in adult periodontitis. J Clin Periodontol 1999; 26:705-9.
Ables AZ, Blumer NA, Valainis GT, Godenick MT, Kajdasz DK, Palesch YY. Fluconazole prophylaxis of severe candida infection in trauma and post-surgical patients: a prospective, double-blind, placebo-controlled trial. Infectious Diseases in Clinical Practice 2000; 9:169-75.
Wallace MB, Durkalski V, Vaughan JA, Palesch YY, Libby E, Jowell P, Nicki N, Schutz S, Leung J, Cotton, PB. Age and alarm symptoms do not predict upper GI pathology at endoscopy among patients with dyspepsia. A multicenter database study of 12,113 patients. Gut. 2001; 48:0-5.
Mitas M, Mikhitarian K, Walters C, Baron P, Elliot B, Brothers T, Robinson J, Metcalf J, Palesch YY, Zhang Z, Gillanders WE, Cole DJ. Quantitative real-time RT-PCR detection of breast cancer micrometastises using a multi-gene marker panel. Int J Cancer 2001; 93:162-171.
Hebert RL, Palesch YY, Mauldin PD, Tarnasky P, Aabakken L, Hennessey W, Cotton PB. DDQ-15 Health-related quality of life instrument for patients with digestive disorders. Health Services and Outcomes Research Methodology 200; 2:137-156.
Durkalski VL, Palesch YY, Pineau BC, Vining DJ, Cotton PB. The virtual colonoscopy study: a large multicenter clinical trial designed to compare two diagnostic screening procedures. Controlled Clinical Trials. 2002; 23:570-583.
Durkalski VL, Palesch YY, Lipsitz S, Rust P. The analysis of clustered matched-pair data for a non-Inferiority study design. Statistics in Medicine, 2003; 22:279-290.
Durkalski VL, Palesch YY, Lipsitz S, Rust P. The analysis of clustered matched-pair data. Statistics in Medicine. 2003; 22:2417-2428.
Michels PJ, Palesch YY. Anxiety and anger among family practice residents: a South Carolina Family Practice Research Consortium study. Academic Medicine. 2003; 78:69-79.
The IMS Investigators. Combined Intravenous and Intra-arterial Recanalization for Acute Ischemic Stroke: The Interventional Management of Stroke (IMS) Study. Stroke. 2004; 35: 904-911.
Cotton PB, Durkalski VL, Pineau BC , Palesch YY, et al. Virtual colonoscopy (CT colonography): A multicenter comparison with standard colonoscopy for detection of mass lesions. JAMA. 2004; 291:1713-1719.