Edward L. Hogan, M.D.

Professor of Neurology and Biochemistry and Molecular Biology,
Room 304D, Clinical Science Bldg. - 96 Jonathan Lucas Street,
Medical University of South Carolina, Charleston, SC.

Positions held include:
Professor of Neurology and Biochemistry and Molecular Biology 1973 - present;;
Chair of Neurology, 1973 - 2000;
NIH Study sections: Neurology B, 1981 - 1985 (Chair, 1983 - 1985);
Neurosciencees Training Committee, 1990 - 1993.
Editorial Boards: J. Neurol. Sci., Metab. Brain Disease.
Director, Neurology Residency Training Program, 1973 - 1997;
Adjunct Professor of Microbiology, national University of Ireland, galway, 2003-

Phone: (843) 792-3221
Fax: (843) 792 8626
Email: hoganel@musc.edu

Research Interests:

Autoimmunity is necessary in the mechanism of the inflammatory demyelination of multiple sclerosis (MS), but is insufficient explanation of pathogenesis. A promising insight to MS initiation prompts our current pursuit of the finding in 2002 of molecular mimicry of microbial and myelin glycolipids: plausible triggers of an innate-adaptive sequence generating autoreactivity.

Interests ranging from MS to spinal disorders including traumatic injury, neuromuscular disease and stroke have driven bench work on CNS glycolipids extending to new and bioactive glycoconjugates, mechanisms of genetic and immune demyelination, and pathways of neural damage involving calcium, calpain, and sphingoid/cytokine mediators. Efforts to translate bench to patient have fostered studies of drugs in acute stroke patients, of viral myelitis, of enzymes in human cerebrospinal fluid, etc.

Selected Recent Publications:

Hogan EL, Dasgupta S, Paldanius M, Zahringer U, Moran, AP. Cross-reactivity of 3-SAG cerbroside with mycoplasma glycolipid: Molecular mimicry potentially relevant to multiple sclerosis (MS). Presented at Annual Meeting of the Society for Neuroscience, in session on "Demyelinating Disorders: Mechanisms of Disease - MS," Number 213.14, New Orleans, LA, USA, November 9, 2003.

Moran AP, Prendergast MM, Hogan EL. Sialosyl-galactose: a common denominator of Guillain-Barre and related disorders? J Neurol Sci. 2002 Apr 15;196(1-2):1-7. Review.
PMID: 11959149 [PubMed - indexed for MEDLINE]

Dasgupta S, Levery SB, Hogan EL. 3-O-acetyl-sphingosine-series myelin glycolipids: characterization of novel 3-O-acetyl-sphingosine galactosylceramide. J Lipid Res. 2002 May;43(5):751-61. PMID: 11971946 [PubMed - indexed for MEDLINE]

Ray SK, Hogan EL, Banik NL. Calpain in the pathophysiology of spinal cord injury: neuroprotection with calpain inhibitors. Brain Res Brain Res Rev. 2003 May;42 (2):169-85. Review. PMID: 12738057 [PubMed - indexed for MEDLINE]

Tyor WR, Avgeropoulos N, Ohlandt G, Hogan EL. Treatment of spinal cord impact injury in the rat with transforming growth factor-beta. J Neurol Sci. 2002 Aug 15;200(1-2):33-41. PMID: 12127673 [PubMed - indexed for MEDLINE]