Gregory W. Warr Professor, Biochemistry and Molecular Biology MUSC, Charleston, SC  Ph.D., University of London warrgw@musc.edu
Research:  Molecular basis of immune recognition & ecogenomics. The focus of my laboratory is on the molecular basis of immune recognition, and how mechanisms of self/non-self discrimination have evolved. We use a variety of marine organisms, from invertebrates to dolphins, to investigate at a molecular level the nature of the organism’s response to environmental challenges, including infectious disease.
Publications: Hikima J, Lennard Richard ML, Wilson MR, Miller NW, Warr GW, Interaction between E-protein and Oct transcriptionfactors in the function of the catfish IGH enhancer. Dev. Comp. Immunol. In Press Mancia, A, Warr GW, Chapman RW, A transcriptomic analysis of the stress induced by capture-release health assessmentstudies in wild dolphins, (Tursiops truncatus). Mol. Ecol. 2008 In press Hikima J, Lennard Richard ML, Wilson MR, Miller NW, Warr GW. Function of E-protein dimers expressed in catfish lymphocytes.Mol Immunol. 2008;45:1165-70 de la Vega E, O'Leary NA, Shockey JE, Robalino J, Payne C, Browdy CL, Warr GW, Gross PS.Anti-lipopolysaccharide factor in Litopenaeus vannamei (LvALF): A broad spectrum antimicrobial peptide essential for shrimp immunity against bacterial and fungal infection. Mol Immunol. 2008;45:1916-1925 Lennard ML, Hikima J, Ross DA, Kruiswijk CP, Wilson MR, Miller NW, Warr GW (2007) Characterization of an Oct1 orthologue in the channel catfish, Ictalurus punctatus: a negative regulator of immunoglobulin gene transcription? BMC Mol Biol. 31;8:8 Mancia A, Romano TA, Gefroh HA, Chapman RW, Middleton DL, Warr GW, Lundqvist ML (2007) Characterization of the immunoglobulin A heavy chain gene of the Atlantic bottlenose dolphin (Tursiops truncatus). Vet Immunol Immunopathol. 118:304-9 Jenny MJ, Chapman RW, Mancia A, Chen YA, McKillen DJ, Trent H, Lang P, Escoubas J-M, Bachere E, Boulo V, Liu ZJ, Gross PS, Cunningham C, Cupit PM, Tanguy A, Guo X, Moraga D, Boutet I, Huvet A, De Guise S, Almeida JS, Warr GW (2007) A cDNA Microarray for Crassostrea virginica and C. gigas. Marine Biotechnology;9:577-91 Lundqvist ML, McElveen BR, Middleton DL, Warr GW. (2007) Enhancer and promoter activity in the JH to IGHM intron of the Pekin duck, Anas platyrhynchos Dev Comp Immunol. 31:286-95 Robalino J, Bartlett TC, Chapman RW, Gross PS, Browdy CL, Warr GW. (2007) Double-stranded RNA and antiviral immunity in marine shrimp: Inducible host mechanisms and evidence for the evolution of viral counter-responses. Dev Comp Immunol. 31:539-47 Robalino J, Almeida JS, McKillen D, Colglazier J, Trent HF, Chen YA, Peck ME, Browdy CL, Chapman RW, Warr GW, Gross PS (2007) .Insights into the immune transcriptome of the shrimp Litopenaeus vannamei: tissue-specific expression profiles and transcriptomic responses to immune challenge. Physiol Genomics. 29:44-56.