Ph.D., Royal Institute of Pharmacy, Sweden

tom_walle@smtpgw.musc.edu

Carcinogenesis: prevention and toxicology. Role of transport and metabolism in the covalent binding of carcinogens to cellular DNA and proteins. Effects of inducers of the transporters and metabolic enzymes in marine systems.

Publications:

Kauppert, P., U.K. Walle and T. Walle: Expression of carcinogen-metabolizing enzymes in the liver of the marine fish Fundulus heteroclitus compared to man. Proceedings of the Carolinas Society of Environmental Toxicology and Chemistry (SETAC) Annual Meeting, Charleston, SC, April 2-4, 2003.

Vaidyanathan Jb and T Walle: Glucuronidation and sulfation of the tea flavonoid (–)-epicatechin by the human and rat enzymes. Drug Metab Dispos, 30: 897-903, 2002.

Whitley, A. C, G. D. Stoner, M. V. Darby and T. Walle: Intestinal epithelial cell accumulation of the cancer preventive polyphenol ellagic acid – extensive binding to protein and DNA. Biochem. Pharmacol., in press, 2003.

Walle, T., Y. Otake, J.A. Brubaker, U.K. Walle and P.V. Halushka: Disposition and metabolism of the flavonoid chrysin in normal volunteers. Br. J. Clin. Pharmacol., 51: 143-146, 2001.

 Galijatovic, A., Y. Otake, U.K. Walle and T. Walle: Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in Caco-2 cells - Potential role in carcinogen bioinactivation. Pharm. Res., 18: 374-379, 2001.

169. Vaidyanathan, J.b. and T. Walle: Transport and metabolism of the tea flavonoid (–)-epicatechin by the human intestinal cell line Caco-2. Pharm. Res. 18: 1420-1425, 2001.

170. Walle, T., U.K. Walle and P.V. Halushka: Carbon dioxide is the major metabolite of quercetin in humans. J. Nutr.131:2648-2652, 2001.

171. Otake, Y. and T. Walle: Oxidation of the flavonoids galangin and kaempferide by human liver microsomes and CYP1A1, CYP1A2, and CYP2C9. Drug Metab. Dispos. 30: 103-105, 2002.

172. Walle, T. and U. K. Walle: Induction of human UDP-glucuronosyltransferase 1A1 by flavonoids – structural requirements. Drug Metab. Dispos, 30: 564-569, 2002.

173. Otake, Y., F. Hsieh and T. Walle: Glucuronidation versus oxidation of the flavonoid galangin by human liver microsomes and hepatocytes. Drug Metab. Dispos. 30: 576-581, 2002.

174. Handley, D. A., C. H. Senanayake, W. Dutczak, J. L. Benovic, T. Walle, R. B. Penn, H. S. Wilkinson, G. J. Tanoury, R. G. Andersson, F. Johansson and J. Morley: Biological actions of formoterol isomers. Pulm. Pharmacol. Ther. 15: 135-145, 2002.

175. Vaidyanathan Jb and T Walle: Glucuronidation and sulfation of the tea flavonoid (–)-epicatechin by the human and rat enzymes. Drug Metab Dispos, 30: 897-903, 2002.

176. Walle, T., T. S. Vincent and U. K. Walle: Evidence of covalent binding of the dietary flavonoid quercetin to DNA and protein in human intestinal and hepatic cells. Biochem. Pharmacol., 65:1603-1610, 2003.

177. Kaldas, M. I., U. K. Walle and T. Walle: Resveratrol transport and metabolism by human intestinal Caco-2 cells. J. Pharm. Pharmacol. 55:307-312, 2003.

178. Walle, T., R. A. Walgren, U. K. Walle, A. Galijatovic and J. b. Vaidyanathan: Understanding the bioavailability of flavonoids through studies in Caco-2 cells. Chapter 13 in “Flavonoids in Health and Disease”, vol. 2, eds. C. Rice-Evans and L. Packer, Marcel Dekker, 349-361, 2003.

179. Whitley, A. C, G. D. Stoner, M. V. Darby and T. Walle: Intestinal epithelial cell accumulation of the cancer preventive polyphenol ellagic acid – extensive binding to protein and DNA. Biochem. Pharmacol, 66:907-915, 2003.

180. Vaidyanathan, J. b. and T. Walle: Cellular uptake and efflux of the tea flavonoid (–)-epicatechin-3-gallate in the human intestinal cell line Caco-2. J. Pharmacol. Exptl. Ther. 307: 745-752, 2003.

181. Walle, T. and U. K. Walle: The -D-glucoside and SGLT1-inhibitor phloridzin is transported by both SGLT1 and MRP1/MRP2. Drug Metab. Dispos. 31:1288-1291, 2003.

182. Walle, T.: Absorption and metabolism of flavonoids. Free Radic. Biol. Med 36:829-837, 2004.

183. Walle, T., F. Hsieh, M. H. DeLegge, J. E. Oatis, Jr., and U. K. Walle: High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab. Dispos. 32:1377-82, 2004.

184. Walle, T., A. M. Browning, L. L. Steed, S. G. Reed, and U. K. Walle: Flavonoid glucosides are hydrolyzed and thus activated in the oral cavity in humans. J. Nutr., 135:48-52, 2005.

185. Hadden, M. K., T. Walle and T. A. Dix: Cellular uptake of a radiolabelled analogue of neurotensin in the Caco-2 cell model. J. Pharm. Pharmacol. 57:327-333, 2005.

186. Wen, X., U. K. Walle and T. Walle: 5,7-Dimethoxyflavone down-regulates CYP1A1 expression and benzo[a]pyrene-induced DNA binding in Hep G2 cells. Carcinogenesis 26:803-809, 2005.

187. McMillan, J. M., U. K. Walle and T. Walle: S-Adenosyl-L-methionine: Transcellular transport and uptake by Caco-2 cells and hepatocytes. J. Pharm. Pharmacol. 57:599-605, 2005.

188. Kaldas, M. I., U. K. Walle, H. van der Woude, J. M. McMillan and T. Walle: Covalent binding of the flavonoid quercetin to human serum albumin. J. Agric. Food Chem. 53:4197-4197, 2005.

189. Whitley, A. C, D. H. Sweet and T. Walle: The dietary polyphenol ellagic acid is a potent inhibitor of hOAT1. Drug Metab. Dispos.33:1097-1100, 2005.

190. Browning, A. M., U. K. Walle and T. Walle: Flavonoid glycosides inhibit oral cancer cell proliferation – role of cellular uptake and hydrolysis to the aglycones. J. Pharm. Pharmacol. 57: 1037-1042, 2005.

191. Wen, X. and T. Walle: Preferential induction of CYP1B1 by benzo[a]pyrene in human oral epithelial cells: Impact on DNA adduct formation and prevention by polyphenols. Carcinogenesis, in press, 2005.