Professor and Chair, DCI, Professor of Medicine, Nephrology
Vice President for Academic Affairs & Provost
Medical University of South Carolina, Charleston, SC
M.D., Ohio State University
raymondj@musc.edu
Basic signal transduction pathways. My laboratory studies basic signal transduction pathways. We are particularly interested in mapping pathways that regulate proliferation of cells of ion transport. We use state of the art molecular and cellular biology methods, physiological methods, and novel biophysical instrumentation. In one example of this approach, we have been characterizing urea transporters in stingrays. These studies involved determining urea clearances in living anesthetized animals, as well as efforts to clone the cDNA's for a family of urea transporters from these animals.
Publications:
Grewal, J.S., Luttrell, L.M., Raymond, J.R. (2001) G protein-coupled receptors desensitize and down-regulate
EGF receptors in renal mesangial cells. J. Biol. Chem. 276:27335-27344.
Mukhin, Y.V., Garnovskaya, M.N., Collinsworth, G., Bell, J.L.,
Tholanikunnel, B.G., Pettus, T., Jaffa, A.A., Fitzgibbon, W., Ploth, D.W.,
Raymond, J.R., Garnovskaya, M.N. (2001) Bradykinin B2 receptors activate
Na+/H+ exchange in mIMCD-3 cells via Ca2+/calmodulin. J. Biol. Chem.
276: 17339-17346.
Della Rocca, G.J., Mukhin, Y.V., Garnovskaya, M.N., Daaka, Y., Clark,
G., Luttrell, L.M., Lefkowitz, R.J., Raymond, J.R. (1999) Serotonin
5-HT1A receptor-mediated MAP kinase activation requires calcium/calmodulin-mediated
receptor endocytosis. J. Biol. Chem. 274:4749-4753.