David W. Ploth Professor, Medicine Director, Division Nephrology MUSC , Charleston, SC M.D., Iowa University plothdw@musc.edu
Research: Role of mechanisms of altered renal function in animal models of hypertension, particularly the role of the angiotensin system in renal hypertension. Research interests focus on renal physiology and pathophysiology of hypertension in mammals and fishes. We are particularly interested in mechanisms of blood pressure regulation and effects of renal hormones on renal hemodynamic and absorptive function. Most recent interests have led us to explore comparative molecular biology and functional characteristics of urea transporters in elasmobranchs compared to mammals.
Publications: Janech, M.G., Gefroh, H., Cwengros, E.E., Sulikowski, J.A., Ploth, D.W., and *Fitzgibbon, W.R. (2008). Cloning of Urea Transporters from the Kidneys of Two Batoid Elasmobranchs: Evidence for a Common Elasmobranch Urea Transporter Isoform. Marine Biology 153:1173-1179. Janech, M.G., Gefroh, H.A., Cwengros, E.E., Sulikowski, J.A., Ploth, D.W., and Fitzgibbon, W.R. (2007). Cloning of urea transporters from the kidneys of two batoid elasmobranchs: evidence for a common elasmobranch urea transporter isoform. Mar. Biol.(online D110.107/s00227-007-0889—4). Ploth, D.W. (2007) Southern Society Founder’s Medal Acceptance. The Am Journal of The Medical Sciences. 334:9-10. Navar, L.G. and Ploth, D.W. (2007) Pathophysiology of Renovascular Hypertension. In: Hypertension Primer: The Essentials of High Blood Pressure, 4th Edition, edited by Izzo JL, Sica, D, and Black, HR. Lippincott Williams & Wilkins, p138-141. Janech, M.G., Fitzgibbon, W.R., Nowak, M., Miller, D.H. and Ploth, D.W. (2006). Cloning and Functional Characterization of a Second Urea Transporter Isoform (strUT-2) from the Kidney of the Atlantic Stingray. American Journal of Physiology (Regulatory, Integrative and Comparative Physiology) R844-R853. Janech, M.G., Fitzgibbon, W.R., Ploth, D.W., Lacy, E.R. and Miller, D.H. (2006). Effect of Environmental Salinity on Plasma Composition and Renal Function of the Atlantic Stingray, a Euryhaline Elasmobranch. American Journal of Physiology (Renal Physiol) 291:F770-780. Budisavlievic, MN, Stewart, L, Sahn, SA, and D.W.Ploth. (2003). Hyponatremia associated with 3,4-methylenedioxymethylamphetetamine(“ectasy”) abuse. Am J. Med. Sciences. 326:89-93. Ploth, D.W., Shepp, P.H., Counts, C.C., and F.H. Hutchison. (2003). Prospective analysis of global costs for maintenance of patients with end stage renal disease. Am J Kidney Dis. 42:12-21. Mackenzie, H. and D.W. Ploth. (2003). Effects of low dose converting enzyme inhibitor on renal function in two-kidney, one-clip hypertensive rats. Submitted for publication, Am. Journ. Physiol: Integrative Physiology. Janech, M.G., Fitzgibbon, W.R., Ploth, D.W., Lacy, E.R., and D.H. Miller. (2003). Effect of environmental salinity on plasma composition and renal function in the Atlantic Stingray, a marine euryhaline elasmobranch. (in preparation).

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