David W. Ploth


Professor, Medicine
Director, Division Nephrology
MUSC , Charleston, SC

M.D., Iowa University


plothdw@musc.edu

Research:
Role of mechanisms of altered renal function in animal models of hypertension, particularly the role of the angiotensin system in renal hypertension. Research interests focus on renal physiology and pathophysiology of hypertension in mammals and fishes. We are particularly interested in mechanisms of blood pressure regulation and effects of renal hormones on renal hemodynamic and absorptive function. Most recent interests have led us to explore comparative molecular biology and functional characteristics of urea transporters in elasmobranchs compared to mammals.		  

Publications:

Janech, M.G., Fitzgibbon, W.R., Ploth, D.W., Lacy, E.R. and Miller, D.H. (2003). Effect of Environmental Salinity on Plasma Composition and Renal Function of the Atlantic Stingray, a Euryhaline Elasmobranch. in preparation.

Janech, M.G., Cwengros, E., Gefroh, H., Sulikowski, J.A., Ploth, D.W. and Fitzgibbon, W.R. (2003). A Common Renal Urea Transporter Isoform is Expressed in the Kidneys of Elasmobranchs. in preparation.

Janech, M.G., Fitzgibbon, W.R., Nowak, M., Miller, D.H. and Ploth, D.W. (2003). Identification of a Second Urea Transporter Isoform in the Kidney of the Atlantic Stingray. in preparation.

Janech, M.G., Chen, R., Paul R.V., Nowak, M., McFee, W., Fitzgibbon, W.R. and Ploth, D.W. (2002) Physiological and molecular characterization of a urea transporter from the kidney of the short-finned pilot whale, Globcephala macrorhynchus American Journal of Physiology (Regulatory and Comparative Physiology) 282: R1490-R1500.

Janech, M.G., Fitzgibbon, W.R., Chen. R., Paul, R.V., Nowak, M., Miller, D.H. and D.W. Ploth. (2002). Physiological and molecular characterization of a rrea transporter from the kidney of the euryhaline Atlantic stingray, Dasyatis sabina. in press, American Journal of Physiology (Renal, Fluid and Electrolyte Physiology).

Mukhin, Y.V., Vlasova, T., Jaffa, A.A., Collinsworth, G., Bell, J.L., Tholanikunnel, B., Pettus, T., Fitzgibbon, W.R., Ploth, D.W., Raymond, J.R. and Garnovskaya, M.N. (2001). Bradykinin B2 receptors activate Na+/H+ Exchange in mIMCD-3 cells via janus kinase 2 and Ca2+/calmodulin. Journal of Biological Chemistry 276: 17339-17346.