Research Assistant Professor
Department of Pediatrics
MUSC, Charleston, SC
Ph.D., Clemson University
pedenada@musc.edu
Sub-lethal toxicological effects of environmental contaminants. We assess various health effects depending on the mechanism of action of the contaminant and endpoints often include the immune, endocrine, metabolic, and nervous system. Clearly, there is a link between marine/wildlife health and human health that can be assessed using sentential wildlife species. In fact, effects in wildlife are often our first clue to potential effects on human health. Current research directions include children’s environmental health and marine mammal health. Present studies are assessing children’s health effects of methyl and ethyl mercury exposure, during key developmental stages, on the immune, metabolic, and nervous systems using a rodent model. Additional, studies include the development of immunological tests to monitor and assess health risks in bottlenose dolphin populations, both ex vivo and in vitro, following exposure to marine contaminants.
Experiments Environ Health Perspect: doi:10.1289/ehp.8143. [Online 21 September 2005] http://ehp.niehs.nih.gov/docs/2005/8143/abstract.html
" R. L. Dickerson, J. A. Hoover, M. M.
Peden-Adams, W. E. Mashburn, C. A. Allen, and D. S. Henshel (1996).
Alterations in Chicken Embryonic Development as a Sensitive Indicator of
2,3,7,8-TCDD Exposure. in: Environmental Toxicology and Risk Assessment:
Biomarkers and Risk Assessment (5th Vol). D. A. Bengtson and D. S.
Henshel Eds. American Society of Testing and Materials, Philadelphia.
" J. Lamb, R. Balcomb, C. Bens, R. Cooper, J. Gorsuch, P. Matthiessen,
M. Peden-Adams, E. Voit (1998). Hazard Identification and
Epidemiology. in: Principles and Processes for Evaluating Endocrine
Disruption in Wildlife. R. Kendall, R. Dickerson, J. Geisy, and W. Suk
Eds. SETAC Special Publications Series. CRC Press, Boca Raton, Fl.
" J.M. Keller, M.M. Peden-Adams, A.A. Aguirre. (2005).
Immunotoxicology and implications for reptilian health. in: Toxicology
and the Environment: Reptilian Toxicology. Eds: E. Oberdörster and S.
Gardner. CRC Press, Boca Raton - in press.
Journal Articles
" M. M. Peden-Adams, K. R. Alonso, S. Skipper, W. E. Mashburn, C.
Godard, D. S. Henshel, R. L. Dickerson (1998). Effects of
Environmentally Relevant Concentrations of 2,3,7,8-TCDD on Domestic
Chicken Immune Function and Mixed Function Oxidase Activity in Parental
and F1 Generations. Chemosphere, 37:1923-1939, Invited.
" K. R. Alonso, M. M. Peden-Adams, J. Y. Liu, D. S. Henshel, and
R. L. Dickerson (1998). Effects of In Ovo Exposure to 2,3,7,8-TCDD on F1
Generation Adult Chickens. Chemosphere, 37:1873-1883, Invited.
" A.C. Dudley, M.M. Peden-Adams, J.G. EuDaly, R. Pollenz, D.E.
Keil (2001). An Aryl Hydrocarbon Receptor Independent Mechanism of JP-8
Jet Fuel Immunotoxicity in Ah Responsive and Ah Nonresponsive Mice.
Toxicological Sciences 59:251-259.
" M.M. Peden-Adams, J. EuDaly, E. EuDaly, A.C. Dudley, J.
Zeigler, A. Lee, J. Robbs, G. Gilkeson, D.E. Keil. (2001). Evaluation of
Immunotoxicity induced by Single or Concurrent Exposure to
n,n-Diethyl-m-toluamide (DEET), Pyridostigmine Bromide (PYR), and JP-8
jet fuel. Toxicology and Industrial Health. 17: 192-209, Invited.
" C. T. Allen, M. M. Peden-Adams, J. EuDaly, D. E. Keil. (2003)
Subchronic Exposure To Ellagic Acid Impairs Cytotoxic T-Cell Function
And Suppresses Humoral Immunity In Mice. Immunopharmacology and
Immunotoxicology, 25 (3): 409-422.
" D. E. Keil, A. Warren, J. G. EuDaly, M. Jenny, J. Smythe, M. M.
Peden-Adams. (2003) Immunological Function is Altered in F1 Adult
Mice Exposed to JP-8 Jet Fuel during In Utero Development. Toxicological
Sciences 76(2): 347-56.
" M.M. Peden-Adams??A.C Dudley, J.G. EuDaly, C.T. Allan, G.S.
Gilkeson, D.E. Keil. (2004) Pyridostigmine Bromide (PYR) Alters Immune
Function in B6C3F1 Mice Immunopharmacology and Immunotoxicology, 26(1):
1-15.
" D. E. Keil, A. C. Dudley, J. G. EuDaly, J. Dempsey, G. S. Gilkeson,
M. M. Peden-Adams (2004). A Profile of Immunological and
Hematological Effects Observed in B6C3F1 Mice Exposed To JP-8 Jet Fuel
for 14 Days. Journal of Toxicology and Environmental Health, Part A,
67:1-21.
" J.M. Keller, P.D. McClellan-Green, A.M. Lee, M.D. Arendt, P.P. Maier,
A.L. Segars, J.D. Whitaker, D.E. Keil, M.M. Peden-Adams (2005).
Mitogen-induced lymphocyte proliferation in loggerhead sea turtles:
comparison of methods and effects of gender, plasma testosterone
concentration, and body condition on immunity. Veterinary Immunology and
Immunopathology, 103 (3-4):269-281.
" Jin Yu, Mark S. Kindy, Blake C. Ellis, John E. Baatz, Margie Peden-Adams,
Tara J. Ellingham, Daynna J. Wolff, Patricia A. Fair, and Sebastiano
Gattoni-Celli. (in press) Establishment of Epidermal Cell Lines Derived
from the Skin of the Atlantic Bottlenose Dolphin (Tursiops Truncatus).
Anatomical Record- Accepted.
" M.M. Peden-Adams? J.G. EuDaly, S. Dabra, A. EuDaly, L.
Heesemann, J. Smythe, D.E. Keil. Suppression of Immune Function and
Possible Endocrine Modulation Caused By The Perfluorinated Insecticide
Sulfluramid. Submitted.
" J.M. Keller, P.D. McClellan-Green, J.R. Kucklick, D.E. Keil, M.M.
Peden-Adams. Effects of organochlorine contaminants on loggerhead
sea turtle immunity: Comparison of a correlative field study and in
vitro exposure experiments. Submitted.
TECHNICAL REPORTS
" M.M. Peden-Adams, T. Romano. (2005) Development and
Standardization of A Suite of Assays to Assess Immunotoxicity in the
Bottlenose Dolphin. In: Synopsis of Researcher Meeting Bottlenose
Dolphin Health & Risk Assessment Project. Eds. P.A. Fair and G.D.
Bossart. 2005. NOAA Technical Memorandum NOS NCCOS-in press. 98 pp.
" M.M. Peden-Adams, J.G. EuDaly, L.M. Heesemann, A.M. Lee, T.
Romano. (2005) Lymphocyte Proliferation, NK-cell Activity, & Lysozyme
Activity in Free-Ranging Bottlenose Dolphins (BND) Captured as Part of
the HERA BND Project: Preliminary Data Summary 2003 & 2004. In: Synopsis
of Researcher Meeting Bottlenose Dolphin Health & Risk Assessment
Project. Eds. P.A. Fair and G.D. Bossart. 2005. NOAA Technical
Memorandum NOS NCCOS-in press. 98 pp.
" T. Romano, T., A. Linton, A., M.J. Keogh, D. Beal, M.M. Peden-Adams,
G. Bossart, P. Fair. (2005). Assessment Of Immune Function In Wild
Bottlenose Dolphins (Tursiops Truncatus) Live-Captured In The Indian
River Lagoon, FL And Charleston, SC. In: Synopsis of Researcher Meeting
Bottlenose Dolphin Health & Risk Assessment Project. Eds. P.A. Fair and
G.D. Bossart. 2005. NOAA Technical Memorandum NOS NCCOS-in press. 98 pp.
