Ph.D., Texas A&M University

mcmillan@musc.edu

Environmental contaminant toxicity. My research is focused on the mechanisms by which drugs and other environmental chemicals induce tissue-specific lesions in the liver. Particular interests include (a) determining the contribution of cellular interactions in chemical-induced disease processes and (b) examining the epigenetic mechanisms whereby environmental contaminants, such as trichloroethylene, induce carcinogenesis.

Walgren, J.L.E., Amani, Z., McMillan, J., Locher, M., and Buse, M.G. Effect of R(+)a-lipoic acid on pyruvate metabolism and fatty acid oxidation in rat hepatocytes. Metabolism: Clinical and Experimental. 53, 165-173, 2004.
Walgren, J.L., Jollow, D.J.,and McMillan J.M. Induction of peroxisome proliferation in cultured hepatocytes by a series of halogenated acetates Toxicology. 197, 189-197, 2004.
McMillan, J.M., Walle, U.K., and Walle, T. S-Adenosyl-L-methionine: transcellular transport and uptake by Caco-2 cells and hepatocytes. J. Pharm. Pharmacol.
In Press, 2005.
McMillan, J.M., Walgren, J.L., Kurtz, D.T. (2004). Trichloroethylene hepatocarcinogenicity: hepatocyte mitogenesis and peroxisome proliferation. In Trichloroethylene: The Scientific Basis of Risk Assessment, (L.C. Mohr, D.G. Hoel, D. Jollow. Eds.) pp 53-61. MUSC Press.
Walgren J.L., Kurtz D.T., and McMillan, J.M. Lack of direct mitogenic activity of dichloroacetate and trichloroacetate in cultured rat hepatocytes. Toxicology. Accepted, 2005.
Walgren, J.E., Kurtz, D.T., and McMillan, J.M. Effects of trichloroacetate and dichloroacetate in long-term cultured human hepatocytes. Cell Biol. Toxicol. 16, 257-273, 2000.
Walgren JE, Kurtz DT and McMillan JM. Expression of PPARa in human hepatocytes and activation by TCA and DCA. Res. Commun. Mol. Pathol. Pharmacol. 108, 116-132, 2000.
McMillan, J.M. Galactosamine decreases nitric oxide formation in cultured rat hepatocytes: lack of involvement in cytotoxicity. J. Biochem. Mol. Toxicol., 13, 135-142, 1999.
McMillan, J.M., and Jollow, D.J. Macrophage enhancement of galactosamine hepatotoxicity using a hepatocyte culture system. Res. Commun. Mol. Pathol. Pharmacol., 88, 327-338, 1995.

Apryl Bronley-DeLancey, graduate student (L) and Keashia McKelvey, technician (R) enjoy a lighter moment in the lab.